hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01136

Confidence: Medium

Genename	Protein Name	Links
UTP4	U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component)	UniProt NCBI
NOL7	Nucleolar protein 7 (Nucleolar protein of 27 kDa)	UniProt NCBI
WDR43	WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)	UniProt NCBI
WDR75	WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)	UniProt NCBI
CNRIP1	CB1 cannabinoid receptor-interacting protein 1 (CRIP-1)	UniProt NCBI
NOL11	Nucleolar protein 11	UniProt NCBI
UTP15	U3 small nucleolar RNA-associated protein 15 homolog	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6790901	3.12298019668e-09	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	rRNA modification in the nucleus and cytosol
REAC:R-HSA-6791226	8.63679747203e-07	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	Major pathway of rRNA processing in the nucleolus and cytosol
REAC:R-HSA-8868773	1.13217247672e-06	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	rRNA processing in the nucleus and cytosol
KEGG:03008	1.19700790664e-06	0.571428571429	WDR43 UTP15 WDR75 UTP4	Ribosome biogenesis in eukaryotes
REAC:R-HSA-72312	1.46346941202e-06	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	rRNA processing
GO:0045943	5.09627015667e-06	0.571428571429	NOL11 UTP15 WDR43 WDR75	positive regulation of transcription by RNA polymerase I
GO:0006356	2.01980560179e-05	0.571428571429	NOL11 UTP15 WDR43 WDR75	regulation of transcription by RNA polymerase I
GO:0006364	0.000205648445059	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	rRNA processing
GO:0016072	0.000265505155617	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	rRNA metabolic process
GO:2000234	0.000266683990267	0.428571428571	UTP15 WDR43 WDR75	positive regulation of rRNA processing
GO:0090070	0.000266683990267	0.428571428571	UTP15 WDR43 WDR75	positive regulation of ribosome biogenesis
GO:0006360	0.000385172296353	0.571428571429	NOL11 UTP15 WDR43 WDR75	transcription by RNA polymerase I
REAC:R-HSA-8953854	0.000516765920428	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	Metabolism of RNA
GO:2000232	0.000698035893352	0.428571428571	UTP15 WDR43 WDR75	regulation of rRNA processing
GO:0090069	0.000907263777246	0.428571428571	UTP15 WDR43 WDR75	regulation of ribosome biogenesis
GO:0042254	0.000959205344393	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	ribosome biogenesis
GO:0034470	0.00415838115463	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	ncRNA processing
GO:0005730	0.00531646272278	0.857142857143	NOL11 NOL7 UTP15 WDR75 UTP4 WDR43	nucleolus
GO:0022613	0.00928376179311	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	ribonucleoprotein complex biogenesis
GO:0034660	0.0138615837302	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	ncRNA metabolic process
GO:0044452	0.0253749350715	0.571428571429	NOL11 UTP15 WDR43 UTP4	nucleolar part
GO:0034455	0.0283955176165	0.285714285714	UTP4 NOL11	t-UTP complex
MIRNA:hsa-miR-16-5p	0.0475131879423	0.714285714286	NOL11 WDR43 UTP15 WDR75 UTP4	hsa-miR-16-5p

Edges

Protein 1	Protein 2	Score	Precision	Evidence
UTP4	NOL11	0.916	0.839	bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
UTP4	WDR43	0.798	0.764	hein_WMM bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
UTP4	CNRIP1	0.648	0.686	bioplex (CNRIP1) bioplex_WMM
UTP15	UTP4	0.57	0.656	hein_WMM bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
UTP15	NOL11	0.428	0.576	bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM
UTP4	WDR75	0.398	0.559	bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
UTP15	NOL7	0.06	0.336	bioplex (NOL7) bioplex_WMM youn_WMM treiber_WMM
WDR75	NOL7	0.048	0.295	bioplex (NOL7) bioplex_WMM youn_WMM
NOL7	WDR43	0.023	0.211	bioplex (NOL7) bioplex_WMM youn_WMM
UTP15	WDR43	0.015	0.152	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
WDR75	WDR43	0.015	0.144	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
UTP15	WDR75	0.013	0.151	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
WDR43	NOL11	0.01	0.122	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
WDR75	NOL11	0.009	0.101	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
NOL7	NOL11	0.008	0.068	bioplex (NOL7) bioplex_WMM youn_WMM
NOL7	CNRIP1	0.007	0.005	bioplex_WMM WMM_only
UTP4	NOL7	0.006	0.004	bioplex (NOL7,UTP4) bioplex_WMM youn_WMM treiber_WMM

Images

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Complex HuMAP2_01136 has an average edge precision of 0.333 which is ranked 4194 out of all 6965 complexes.

Related Complexes

Genename	Complexes
UTP4	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03243 HuMAP2_03334 HuMAP2_03580 HuMAP2_04259 HuMAP2_06420
NOL7	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_04259 HuMAP2_06420
WDR43	HuMAP2_01136 HuMAP2_02137 HuMAP2_03243 HuMAP2_03334 HuMAP2_03580 HuMAP2_04259
WDR75	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03334 HuMAP2_04259 HuMAP2_06420
CNRIP1	HuMAP2_01136 HuMAP2_02137 HuMAP2_03243 HuMAP2_03334 HuMAP2_04259 HuMAP2_06420
NOL11	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03243 HuMAP2_03334 HuMAP2_03580 HuMAP2_04259 HuMAP2_06420
UTP15	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03243 HuMAP2_03334 HuMAP2_04259 HuMAP2_06420

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01136