hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01142
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FOXC2 | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | UniProt NCBI |
| PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | UniProt NCBI |
| FAM122A | Protein FAM122A | UniProt NCBI |
| PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | UniProt NCBI |
| SERTAD4 | SERTA domain-containing protein 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 0.0162467151192 | 0.4 | PPP2R2D PPP2R2A | mRNA surveillance pathway |
| KEGG:05142 | 0.0162467151192 | 0.4 | PPP2R2D PPP2R2A | Chagas disease (American trypanosomiasis) |
| GO:0019888 | 0.0211681462149 | 0.6 | PPP2R2D PPP2R2A FAM122A | protein phosphatase regulator activity |
| KEGG:04071 | 0.0249106474345 | 0.4 | PPP2R2D PPP2R2A | Sphingolipid signaling pathway |
| KEGG:04152 | 0.0262966325762 | 0.4 | PPP2R2D PPP2R2A | AMPK signaling pathway |
| KEGG:04728 | 0.030676003082 | 0.4 | PPP2R2D PPP2R2A | Dopaminergic synapse |
| KEGG:04261 | 0.0348468299156 | 0.4 | PPP2R2D PPP2R2A | Adrenergic signaling in cardiomyocytes |
| GO:0019208 | 0.0358473364726 | 0.6 | PPP2R2D PPP2R2A FAM122A | phosphatase regulator activity |
| KEGG:05160 | 0.038710268063 | 0.4 | PPP2R2D PPP2R2A | Hepatitis C |
| KEGG:04390 | 0.0421802717446 | 0.4 | PPP2R2D PPP2R2A | Hippo signaling pathway |
| KEGG:04530 | 0.0439700127241 | 0.4 | PPP2R2D PPP2R2A | Tight junction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP2R2A | PPP2R2D | 1.0 | 0.949 | hein_WMM bioplex (PPP2R2D) bioplex_WMM boldt hein (PPP2R2D) gupta_WMM boldt_WMM |
| PPP2R2A | FAM122A | 0.935 | 0.85 | hein_WMM bioplex (FAM122A) bioplex_WMM hein (PPP2R2A) |
| PPP2R2D | FAM122A | 0.889 | 0.818 | hein_WMM bioplex (FAM122A,PPP2R2D) bioplex_WMM hein (PPP2R2D) |
| FOXC2 | PPP2R2D | 0.695 | 0.718 | hein_WMM bioplex (PPP2R2D) bioplex_WMM |
| SERTAD4 | PPP2R2D | 0.615 | 0.674 | bioplex (PPP2R2D,SERTAD4) bioplex_WMM |
| PPP2R2A | SERTAD4 | 0.254 | 0.478 | bioplex (SERTAD4) bioplex_WMM |
| FOXC2 | FAM122A | 0.01 | 0.134 | hein_WMM bioplex_WMM WMM_only |
| SERTAD4 | FAM122A | 0.009 | 0.113 | bioplex_WMM WMM_only |
| SERTAD4 | FOXC2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PPP2R2A | FOXC2 | 0.0 | 0.008 | hein_WMM bioplex_WMM hein (PPP2R2A) |
Images
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Complex HuMAP2_01142 has an average edge precision of 0.483 which is ranked 2609 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FOXC2 | HuMAP2_01142 HuMAP2_02007 HuMAP2_02812 HuMAP2_03797 |
| PPP2R2D | HuMAP2_01142 HuMAP2_02007 HuMAP2_02812 HuMAP2_03564 HuMAP2_03797 |
| FAM122A | HuMAP2_01142 HuMAP2_02007 HuMAP2_03564 HuMAP2_03797 HuMAP2_04512 HuMAP2_06203 |
| PPP2R2A | HuMAP2_01142 HuMAP2_02007 HuMAP2_03564 HuMAP2_03797 HuMAP2_04512 |
| SERTAD4 | HuMAP2_01142 HuMAP2_02007 HuMAP2_03797 HuMAP2_05108 |