hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01144
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAGE3 | EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) | UniProt NCBI |
| TP53RK | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) | UniProt NCBI |
| TPRKB | EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein) | UniProt NCBI |
| GON7 | EKC/KEOPS complex subunit GON7 | UniProt NCBI |
| OSGEP | Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000408 | 4.91515675326e-14 | 1.0 | TP53RK GON7 LAGE3 OSGEP TPRKB | EKC/KEOPS complex |
| CORUM:7555 | 1.81514593393e-13 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | KEOPS complex |
| HP:0100720 | 8.98679997819e-10 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hypoplasia of the ear cartilage |
| HP:0002410 | 2.99076714937e-09 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Aqueductal stenosis |
| HP:0002036 | 1.58894670824e-08 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hiatus hernia |
| REAC:R-HSA-6782315 | 3.69105881227e-08 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | tRNA modification in the nucleus and cytosol |
| HP:0005108 | 5.13768545876e-08 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the intervertebral disk |
| GO:0070525 | 8.71719597884e-08 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | tRNA threonylcarbamoyladenosine metabolic process |
| HP:0000096 | 3.13456500912e-07 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Glomerulosclerosis |
| HP:0003774 | 8.48589656291e-07 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Stage 5 chronic kidney disease |
| HP:0001181 | 9.03288682556e-07 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Adducted thumb |
| REAC:R-HSA-72306 | 1.54378610998e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | tRNA processing |
| HP:0000601 | 1.69507317585e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hypotelorism |
| HP:0012622 | 1.98072085878e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Chronic kidney disease |
| HP:0000112 | 2.78658791667e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Nephropathy |
| HP:0000100 | 6.70142334533e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Nephrotic syndrome |
| HP:0001622 | 6.70142334533e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Premature birth |
| HP:0001302 | 7.48789722069e-06 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Pachygyria |
| HP:0031263 | 1.21077073586e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal renal corpuscle morphology |
| HP:0000095 | 1.21077073586e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of renal glomerulus morphology |
| HP:0001339 | 1.37513478022e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Lissencephaly |
| HP:0000093 | 1.70229948113e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Proteinuria |
| HP:0020129 | 2.14400007043e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal urine protein level |
| HP:0011035 | 2.32996263732e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal renal cortex morphology |
| HP:0100490 | 3.03801376046e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Camptodactyly of finger |
| HP:0001220 | 3.19701351784e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Interphalangeal joint contracture of finger |
| HP:0000400 | 3.53362419786e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Macrotia |
| HP:0006261 | 3.8029862746e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal phalangeal joint morphology of the hand |
| HP:0012575 | 4.08743818679e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal nephron morphology |
| HP:0004374 | 4.28572779488e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hemiplegia/hemiparesis |
| HP:0012785 | 4.38753105538e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Flexion contracture of finger |
| HP:0009473 | 7.88795412529e-05 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Joint contracture of the hand |
| HP:0012385 | 0.000122403310711 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Camptodactyly |
| HP:0100360 | 0.000131501440152 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Contractures of the joints of the upper limbs |
| CORUM:7556 | 0.000140787732431 | 0.4 | OSGEP LAGE3 | PRAME complex |
| HP:0030044 | 0.000161848382853 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Flexion contracture of digit |
| HP:0002536 | 0.000223698618662 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal cortical gyration |
| HP:0001172 | 0.000230732596549 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal thumb morphology |
| HP:0000083 | 0.000333341880049 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Renal insufficiency |
| HP:0003121 | 0.000352480115418 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Limb joint contracture |
| HP:0002538 | 0.000377544940834 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the cerebral cortex |
| HP:0002269 | 0.000592219314117 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of neuronal migration |
| HP:0002353 | 0.000802746766761 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | EEG abnormality |
| HP:0010549 | 0.000858369037556 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Weakness due to upper motor neuron dysfunction |
| HP:0030178 | 0.000967765284185 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of central nervous system electrophysiology |
| HP:0009810 | 0.000978202345547 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of upper limb joint |
| HP:0100790 | 0.00112168198795 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hernia |
| HP:0001511 | 0.00114507726185 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Intrauterine growth retardation |
| HP:0002577 | 0.00161656656863 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the stomach |
| HP:0001311 | 0.00199683222853 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal nervous system electrophysiology |
| REAC:R-HSA-8953854 | 0.00262978456954 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Metabolism of RNA |
| HP:0003110 | 0.00263233610637 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of urine homeostasis |
| HP:0001967 | 0.0030633405246 | 0.4 | TP53RK OSGEP | Diffuse mesangial sclerosis |
| HP:0100543 | 0.00335497414372 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Cognitive impairment |
| HP:0005918 | 0.00335497414372 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal finger phalanx morphology |
| HP:0012211 | 0.00338136145817 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal renal physiology |
| HP:0000377 | 0.00368195710745 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the pinna |
| HP:0000316 | 0.00373868304213 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hypertelorism |
| HP:0012444 | 0.00415423066831 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Brain atrophy |
| HP:0000347 | 0.00427904215876 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Micrognathia |
| HP:0001371 | 0.00434248675252 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Flexion contracture |
| HP:0009118 | 0.00437447096145 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Aplasia/Hypoplasia of the mandible |
| GO:0002949 | 0.00450823411379 | 0.4 | OSGEP TPRKB | tRNA threonylcarbamoyladenosine modification |
| HP:0009116 | 0.00467030011526 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Aplasia/Hypoplasia involving bones of the skull |
| HP:0100261 | 0.00484096107077 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal tendon morphology |
| HP:0001966 | 0.00487153229182 | 0.4 | TP53RK OSGEP | Mesangial abnormality |
| HPA:015010_23 | 0.0054060035696 | 0.8 | TP53RK GON7 LAGE3 TPRKB | epididymis; glandular cells[Approved,High] |
| HP:0002118 | 0.00708652002063 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the cerebral ventricles |
| HP:0007367 | 0.00713259280425 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Atrophy/Degeneration affecting the central nervous system |
| HP:0009122 | 0.00731912076265 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Aplasia/hypoplasia affecting bones of the axial skeleton |
| HP:0001197 | 0.0079005654453 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of prenatal development or birth |
| HP:0100807 | 0.00807848245275 | 0.6 | TP53RK LAGE3 OSGEP | Long fingers |
| HP:0001257 | 0.00830687240879 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Spasticity |
| HP:0000164 | 0.00997055798897 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the dentition |
| HP:0000277 | 0.0106387322837 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the mandible |
| HP:0100886 | 0.0113397146668 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of globe location |
| HP:0030791 | 0.012988055981 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal jaw morphology |
| HP:0012210 | 0.0136499696929 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal renal morphology |
| HP:0001276 | 0.0174334049204 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Hypertonia |
| HP:0011277 | 0.0177957000136 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the urinary system physiology |
| HPA:001040_23 | 0.0187935830457 | 0.8 | TP53RK GON7 LAGE3 TPRKB | adrenal gland; glandular cells[Approved,High] |
| HP:0001367 | 0.0207967987511 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal joint morphology |
| HP:0001167 | 0.0227034392536 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of finger |
| HP:0009115 | 0.0234789391763 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Aplasia/hypoplasia involving the skeleton |
| HP:0000356 | 0.0239308330272 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the outer ear |
| HP:0011821 | 0.0258033904131 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of facial skeleton |
| HP:0025033 | 0.0260448941493 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of digestive system morphology |
| HP:0012718 | 0.0260448941493 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Morphological abnormality of the gastrointestinal tract |
| HP:0011729 | 0.0274033471259 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of joint mobility |
| HP:0000252 | 0.0326474959437 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Microcephaly |
| HP:0040195 | 0.0332246010255 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Decreased head circumference |
| HPA:050020_22 | 0.0394072538761 | 0.8 | TP53RK GON7 LAGE3 TPRKB | spleen; cells in white pulp[Approved,Medium] |
| HP:0000077 | 0.0399184873082 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the kidney |
| HP:0002493 | 0.0424736843537 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Upper motor neuron dysfunction |
| HP:0010935 | 0.0446037445864 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormality of the upper urinary tract |
| HP:0004322 | 0.0462525985754 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Short stature |
| HP:0011297 | 0.0494900867638 | 0.8 | TP53RK LAGE3 OSGEP TPRKB | Abnormal digit morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAGE3 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) fraction boldt_WMM |
| TP53RK | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP,TP53RK) bioplex_WMM boldt youn_WMM hein (OSGEP) boldt_WMM |
| TPRKB | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) boldt_WMM |
| GON7 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM hein (OSGEP) |
| TP53RK | GON7 | 0.878 | 0.812 | hein_WMM bioplex (TP53RK) bioplex_WMM |
| TP53RK | TPRKB | 0.87 | 0.803 | hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM |
| TP53RK | LAGE3 | 0.55 | 0.643 | hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM |
| LAGE3 | TPRKB | 0.021 | 0.188 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TPRKB | GON7 | 0.013 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| LAGE3 | GON7 | 0.011 | 0.14 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01144 has an average edge precision of 0.653 which is ranked 1635 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LAGE3 | HuMAP2_01144 HuMAP2_01706 HuMAP2_02664 HuMAP2_03463 HuMAP2_04134 HuMAP2_04445 HuMAP2_05672 |
| TP53RK | HuMAP2_01144 HuMAP2_01706 HuMAP2_03463 HuMAP2_04134 |
| TPRKB | HuMAP2_01144 HuMAP2_01706 HuMAP2_03463 HuMAP2_04134 |
| GON7 | HuMAP2_01144 HuMAP2_01706 HuMAP2_03463 HuMAP2_04134 |
| OSGEP | HuMAP2_01144 HuMAP2_01706 HuMAP2_02664 HuMAP2_03463 HuMAP2_04134 |