hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01146
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | UniProt NCBI |
| DOCK5 | Dedicator of cytokinesis protein 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8849471 | 1.70064822019e-06 | 0.5 | DOCK1 ELMO1 ELMO2 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| CORUM:5337 | 8.39001385941e-06 | 0.333333333333 | DOCK1 ELMO1 | ELMO1-DOCK1 complex |
| CORUM:5343 | 2.51655344529e-05 | 0.333333333333 | DOCK1 ELMO1 | ELMO1-DOCK1-CRKII complex |
| CORUM:5342 | 2.51655344529e-05 | 0.333333333333 | DOCK1 ELMO1 | ELMO1-DOCK1-RAC1 complex |
| REAC:R-HSA-983231 | 3.02487101892e-05 | 0.666666666667 | DOCK5 DOCK1 DOCK4 DOCK3 | Factors involved in megakaryocyte development and platelet production |
| KEGG:05131 | 6.94278084771e-05 | 0.5 | DOCK1 ELMO1 ELMO2 | Shigellosis |
| REAC:R-HSA-9006927 | 8.98156691281e-05 | 0.5 | DOCK1 ELMO1 ELMO2 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 8.98156691281e-05 | 0.5 | DOCK1 ELMO1 ELMO2 | Signaling by PTK6 |
| KEGG:05100 | 0.000103500544784 | 0.5 | DOCK1 ELMO1 ELMO2 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-2029482 | 0.000191968063148 | 0.5 | DOCK1 ELMO1 ELMO2 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 0.0004836193603 | 0.5 | DOCK1 ELMO1 ELMO2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 0.000713906652255 | 0.5 | DOCK1 ELMO1 ELMO2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.000920605178739 | 0.5 | DOCK1 ELMO1 ELMO2 | Signaling by VEGF |
| REAC:R-HSA-9006934 | 0.00129372739211 | 0.666666666667 | DOCK1 ELMO2 ELMO1 DOCK3 | Signaling by Receptor Tyrosine Kinases |
| GO:0051020 | 0.00361538513796 | 0.833333333333 | DOCK5 DOCK1 ELMO1 DOCK4 DOCK3 | GTPase binding |
| REAC:R-HSA-109582 | 0.00385038750362 | 0.666666666667 | DOCK5 DOCK1 DOCK4 DOCK3 | Hemostasis |
| GO:1904694 | 0.00676235117068 | 0.333333333333 | DOCK4 DOCK5 | negative regulation of vascular smooth muscle contraction |
| GO:0005085 | 0.00811327342942 | 0.666666666667 | DOCK5 DOCK1 ELMO1 DOCK3 | guanyl-nucleotide exchange factor activity |
| GO:0045986 | 0.0405595771497 | 0.333333333333 | DOCK4 DOCK5 | negative regulation of smooth muscle contraction |
| GO:0045906 | 0.0405595771497 | 0.333333333333 | DOCK4 DOCK5 | negative regulation of vasoconstriction |
| GO:0003056 | 0.0405595771497 | 0.333333333333 | DOCK4 DOCK5 | regulation of vascular smooth muscle contraction |
| CORUM:5341 | 0.0499726005494 | 0.166666666667 | ELMO1 | ELMO1-DOCK2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELMO1 | DOCK1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK3 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK4 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| ELMO1 | DOCK5 | 1.0 | 0.949 | bioplex (DOCK5,ELMO1) bioplex_WMM |
| ELMO2 | ELMO1 | 0.99 | 0.909 | bioplex (ELMO1) bioplex_WMM |
| ELMO2 | DOCK5 | 0.936 | 0.85 | hein_WMM bioplex (DOCK5) bioplex_WMM |
| ELMO2 | DOCK1 | 0.014 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| DOCK4 | DOCK1 | 0.013 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK4 | ELMO2 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK1 | DOCK5 | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| DOCK3 | DOCK1 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| DOCK3 | DOCK5 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| DOCK4 | DOCK3 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| DOCK3 | ELMO2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| DOCK4 | DOCK5 | 0.01 | 0.134 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01146 has an average edge precision of 0.456 which is ranked 2838 out of all 6965 complexes.
Related Complexes