hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01153
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PLIN5 | Perilipin-5 (Lipid storage droplet protein 5) | UniProt NCBI |
| CDC123 | Cell division cycle protein 123 homolog (Protein D123) (HT-1080) (PZ32) | UniProt NCBI |
| METAP2 | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | UniProt NCBI |
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX) | UniProt NCBI |
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5183 | 0.000234668084372 | 0.333333333333 | EIF2S3 EIF2S2 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| REAC:R-HSA-72731 | 0.000620139265586 | 0.333333333333 | EIF2S3 EIF2S2 | Recycling of eIF2:GDP |
| KEGG:03013 | 0.0009622006058 | 0.5 | PYM1 EIF2S3 EIF2S2 | RNA transport |
| WP:WP107 | 0.0067875461385 | 0.333333333333 | EIF2S3 EIF2S2 | Translation Factors |
| REAC:R-HSA-381042 | 0.00895825109095 | 0.333333333333 | EIF2S3 EIF2S2 | PERK regulates gene expression |
| REAC:R-HSA-72695 | 0.029137346631 | 0.333333333333 | EIF2S3 EIF2S2 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72702 | 0.0375501136505 | 0.333333333333 | EIF2S3 EIF2S2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0375501136505 | 0.333333333333 | EIF2S3 EIF2S2 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0388379782234 | 0.333333333333 | EIF2S3 EIF2S2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0005850 | 0.0405595771497 | 0.333333333333 | EIF2S3 EIF2S2 | eukaryotic translation initiation factor 2 complex |
| MIRNA:hsa-miR-4474-3p | 0.0499802324417 | 0.333333333333 | EIF2S3 METAP2 | hsa-miR-4474-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF2S3 | EIF2S2 | 1.0 | 0.949 | hein_WMM bioplex (EIF2S2) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| CDC123 | EIF2S2 | 0.884 | 0.816 | bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM |
| EIF2S2 | PYM1 | 0.197 | 0.45 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| EIF2S2 | METAP2 | 0.047 | 0.29 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S3 | METAP2 | 0.034 | 0.264 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S3 | PYM1 | 0.026 | 0.221 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| METAP2 | PLIN5 | 0.024 | 0.215 | bioplex (PLIN5) bioplex_WMM |
| CDC123 | PYM1 | 0.007 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | EIF2S3 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | METAP2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| METAP2 | PYM1 | 0.0 | 0.003 | gupta_WMM fraction |
Images
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Complex HuMAP2_01153 has an average edge precision of 0.293 which is ranked 4715 out of all 6965 complexes.
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