hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01171
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LIN7B | Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) | UniProt NCBI |
| LIN7C | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | UniProt NCBI |
| CRB3 | Protein crumbs homolog 3 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | UniProt NCBI |
| MPDZ | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | UniProt NCBI |
| MPP5 | MAGUK p55 subfamily member 5 | UniProt NCBI |
| PATJ | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:848 | 7.88270302729e-08 | 0.5 | MPP5 AMOTL2 MPDZ | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| KEGG:04530 | 5.8954604486e-06 | 0.666666666667 | MPDZ MPP5 CRB3 AMOTL2 | Tight junction |
| REAC:R-HSA-420029 | 0.00232260810736 | 0.333333333333 | MPP5 CRB3 | Tight junction interactions |
| REAC:R-HSA-212676 | 0.00464022545552 | 0.333333333333 | LIN7C LIN7B | Dopamine Neurotransmitter Release Cycle |
| REAC:R-HSA-9609736 | 0.0154864524203 | 0.333333333333 | LIN7C LIN7B | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-112310 | 0.0163206320028 | 0.333333333333 | LIN7C LIN7B | Neurotransmitter release cycle |
| REAC:R-HSA-421270 | 0.0208171179433 | 0.333333333333 | MPP5 CRB3 | Cell-cell junction organization |
| REAC:R-HSA-6794361 | 0.0302745579484 | 0.333333333333 | LIN7C LIN7B | Neurexins and neuroligins |
| GO:0097016 | 0.0405595771497 | 0.333333333333 | LIN7C LIN7B | L27 domain binding |
| WP:WP4239 | 0.049358027697 | 0.333333333333 | MPP5 CRB3 | Epithelial to mesenchymal transition in colorectal cancer |
| CORUM:460 | 0.0499726005494 | 0.166666666667 | MPP5 | CRB1-MPP5-INADL complex |
| CORUM:461 | 0.0499726005494 | 0.166666666667 | MPP5 | MPP4-MPP5-CRB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LIN7C | MPDZ | 1.0 | 0.949 | hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C) |
| LIN7C | PATJ | 1.0 | 0.949 | hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C) |
| LIN7C | MPP5 | 1.0 | 0.949 | hein_WMM bioplex (LIN7C,MPP5) bioplex_WMM hein (LIN7C) gupta_WMM |
| LIN7B | LIN7C | 1.0 | 0.949 | bioplex (LIN7C) bioplex_WMM |
| MPDZ | MPP5 | 0.916 | 0.84 | hein_WMM bioplex (MPP5) bioplex_WMM fraction |
| PATJ | MPP5 | 0.823 | 0.774 | hein_WMM bioplex (MPP5) bioplex_WMM |
| CRB3 | MPP5 | 0.782 | 0.756 | bioplex (MPP5) bioplex_WMM |
| LIN7B | MPP5 | 0.592 | 0.665 | bioplex (MPP5) bioplex_WMM |
| AMOTL2 | MPP5 | 0.587 | 0.662 | hein_WMM bioplex (MPP5) bioplex_WMM |
| LIN7B | MPDZ | 0.011 | 0.141 | bioplex_WMM WMM_only |
| MPDZ | PATJ | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| LIN7B | PATJ | 0.01 | 0.139 | bioplex_WMM WMM_only |
| AMOTL2 | LIN7C | 0.01 | 0.122 | hein_WMM bioplex_WMM hein (LIN7C) |
| AMOTL2 | MPDZ | 0.009 | 0.096 | hein_WMM bioplex_WMM WMM_only |
| CRB3 | MPDZ | 0.008 | 0.093 | bioplex_WMM WMM_only |
| CRB3 | AMOTL2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CRB3 | PATJ | 0.008 | 0.087 | bioplex_WMM WMM_only |
| LIN7B | CRB3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| AMOTL2 | PATJ | 0.008 | 0.085 | hein_WMM bioplex_WMM WMM_only |
| LIN7B | AMOTL2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| CRB3 | LIN7C | 0.008 | 0.07 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01171 has an average edge precision of 0.415 which is ranked 3156 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LIN7B | HuMAP2_01171 HuMAP2_01555 HuMAP2_02238 HuMAP2_03001 |
| LIN7C | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 |
| CRB3 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805 |
| AMOTL2 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04011 HuMAP2_04805 |
| MPDZ | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 |
| MPP5 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805 |
| PATJ | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_03401 |