hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01172
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUZ12 | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | UniProt NCBI |
| EPOP | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | UniProt NCBI |
| PHF19 | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) | UniProt NCBI |
| MTF2 | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | UniProt NCBI |
| EZH2 | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | UniProt NCBI |
| EZH1 | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.43) (ENX-2) (Enhancer of zeste homolog 1) | UniProt NCBI |
| JARID2 | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | UniProt NCBI |
| AEBP2 | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | UniProt NCBI |
| EED | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035098 | 5.76908371004e-24 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | ESC/E(Z) complex |
| GO:0031519 | 5.55585116477e-19 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | PcG protein complex |
| WP:WP2916 | 7.64743806883e-19 | 0.777777777778 | JARID2 SUZ12 AEBP2 MTF2 EZH1 EZH2 EED | Interactome of polycomb repressive complex 2 (PRC2) |
| GO:0035097 | 1.16945124732e-16 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | histone methyltransferase complex |
| GO:0034708 | 1.80810659181e-15 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | methyltransferase complex |
| REAC:R-HSA-212300 | 3.25441281204e-13 | 0.777777777778 | JARID2 AEBP2 SUZ12 PHF19 MTF2 EZH2 EED | PRC2 methylates histones and DNA |
| GO:0045814 | 3.54728221787e-12 | 0.888888888889 | JARID2 AEBP2 EZH1 PHF19 MTF2 SUZ12 EZH2 EED | negative regulation of gene expression, epigenetic |
| CORUM:974 | 1.26984090249e-11 | 0.444444444444 | SUZ12 EED AEBP2 EZH2 | EED-EZH2 complex |
| CORUM:7304 | 1.26984090249e-11 | 0.444444444444 | PHF19 EED EZH2 SUZ12 | HIC1-PCL3L-PCR2 complex |
| REAC:R-HSA-212165 | 5.30959610726e-11 | 0.777777777778 | JARID2 AEBP2 SUZ12 PHF19 MTF2 EZH2 EED | Epigenetic regulation of gene expression |
| CORUM:6910 | 6.30476064954e-09 | 0.333333333333 | PHF19 EED EZH2 | EED-EZH2-PHF19 complex |
| GO:0040029 | 9.02741673314e-09 | 0.888888888889 | JARID2 AEBP2 EZH1 PHF19 MTF2 SUZ12 EZH2 EED | regulation of gene expression, epigenetic |
| GO:0003682 | 3.45374385605e-08 | 0.888888888889 | EPOP EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | chromatin binding |
| GO:1990234 | 5.25719457291e-08 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | transferase complex |
| CORUM:105 | 6.30095061501e-08 | 0.333333333333 | SUZ12 EED EZH2 | Polycomb repressive complex 2 (PRC 2) |
| GO:0044451 | 6.24729577516e-07 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | nucleoplasm part |
| HP:0001814 | 1.05890975613e-06 | 0.333333333333 | SUZ12 EED EZH2 | Deep-set nails |
| WP:WP2369 | 2.60925915779e-06 | 0.444444444444 | EZH2 EED AEBP2 EZH1 | Histone Modifications |
| GO:1902494 | 6.70061170383e-06 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | catalytic complex |
| REAC:R-HSA-3214841 | 1.16864190892e-05 | 0.444444444444 | SUZ12 EED AEBP2 EZH2 | PKMTs methylate histone lysines |
| CORUM:5521 | 1.34129279418e-05 | 0.222222222222 | EZH2 EED | EED-EZH polycomb complex |
| HP:0010300 | 2.32467713027e-05 | 0.333333333333 | SUZ12 EED EZH2 | Abnormally low-pitched voice |
| WP:WP2853 | 3.34361513233e-05 | 0.444444444444 | EZH2 MTF2 AEBP2 JARID2 | Endoderm Differentiation |
| WP:WP4204 | 3.67915356407e-05 | 0.333333333333 | SUZ12 EED EZH2 | Tumor suppressor activity of SMARCB1 |
| HP:0001816 | 3.84395892643e-05 | 0.333333333333 | SUZ12 EED EZH2 | Thin nail |
| CORUM:7375 | 4.02261743042e-05 | 0.222222222222 | SUZ12 EZH2 | BRD7-EZH2-SUZ12 complex |
| CORUM:5502 | 4.02261743042e-05 | 0.222222222222 | EZH2 EED | EED-EZH-YY1 polycomb complex |
| CORUM:1177 | 4.02261743042e-05 | 0.222222222222 | EZH2 EED | Polycomb repressive complex 4 |
| WP:WP4553 | 5.41611549437e-05 | 0.333333333333 | SUZ12 EED EZH2 | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| GO:0046976 | 7.62415024416e-05 | 0.333333333333 | SUZ12 EED EZH2 | histone methyltransferase activity (H3-K27 specific) |
| REAC:R-HSA-8953750 | 0.000180177547323 | 0.333333333333 | SUZ12 EED EZH2 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-74160 | 0.000216210898022 | 0.777777777778 | JARID2 AEBP2 SUZ12 PHF19 MTF2 EZH2 EED | Gene expression (Transcription) |
| GO:0006325 | 0.000225778327613 | 0.777777777778 | EPOP EZH1 PHF19 MTF2 EED EZH2 JARID2 | chromatin organization |
| HP:0001176 | 0.000344494666269 | 0.333333333333 | SUZ12 EED EZH2 | Large hands |
| HP:0001769 | 0.000384127836417 | 0.333333333333 | SUZ12 EED EZH2 | Broad foot |
| HP:0002002 | 0.000814848970559 | 0.333333333333 | SUZ12 EED EZH2 | Deep philtrum |
| REAC:R-HSA-8943724 | 0.000874903450842 | 0.333333333333 | SUZ12 EED EZH2 | Regulation of PTEN gene transcription |
| GO:0070734 | 0.00125570522129 | 0.333333333333 | PHF19 MTF2 EZH2 | histone H3-K27 methylation |
| HP:0001800 | 0.0013859746931 | 0.333333333333 | SUZ12 EED EZH2 | Hypoplastic toenails |
| GO:0031491 | 0.00168817957193 | 0.444444444444 | EED PHF19 MTF2 EZH1 | nucleosome binding |
| REAC:R-HSA-3247509 | 0.00243204538797 | 0.444444444444 | SUZ12 EED AEBP2 EZH2 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 0.00243204538797 | 0.444444444444 | SUZ12 EED AEBP2 EZH2 | Chromatin organization |
| GO:0034968 | 0.0024605537893 | 0.444444444444 | PHF19 MTF2 JARID2 EZH2 | histone lysine methylation |
| HP:0005616 | 0.00258787460084 | 0.333333333333 | SUZ12 EED EZH2 | Accelerated skeletal maturation |
| GO:0010629 | 0.00267198799545 | 0.888888888889 | JARID2 AEBP2 EZH1 PHF19 MTF2 SUZ12 EZH2 EED | negative regulation of gene expression |
| HP:0001582 | 0.00273634648002 | 0.333333333333 | SUZ12 EED EZH2 | Redundant skin |
| WP:WP2857 | 0.00307359033351 | 0.333333333333 | AEBP2 MTF2 JARID2 | Mesodermal Commitment Pathway |
| HP:0001852 | 0.00321540112157 | 0.333333333333 | SUZ12 EED EZH2 | Sandal gap |
| HP:0011304 | 0.00338662912855 | 0.333333333333 | SUZ12 EED EZH2 | Broad thumb |
| WP:WP4239 | 0.00351999320152 | 0.333333333333 | SUZ12 EED EZH2 | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0001609 | 0.00374699276205 | 0.333333333333 | SUZ12 EED EZH2 | Hoarse voice |
| HP:0002213 | 0.00393632560053 | 0.333333333333 | SUZ12 EED EZH2 | Fine hair |
| GO:0018022 | 0.00500918315692 | 0.444444444444 | PHF19 MTF2 JARID2 EZH2 | peptidyl-lysine methylation |
| HP:0009768 | 0.00568358011806 | 0.333333333333 | SUZ12 EED EZH2 | Broad phalanges of the hand |
| GO:0051276 | 0.00574740693261 | 0.777777777778 | EPOP EZH1 PHF19 MTF2 EED EZH2 JARID2 | chromosome organization |
| HP:0010624 | 0.00593252893994 | 0.333333333333 | SUZ12 EED EZH2 | Aplastic/hypoplastic toenail |
| GO:0016571 | 0.00608964522258 | 0.444444444444 | PHF19 MTF2 JARID2 EZH2 | histone methylation |
| HP:0000311 | 0.00645186043433 | 0.333333333333 | SUZ12 EED EZH2 | Round face |
| HP:0000973 | 0.00672243737522 | 0.333333333333 | SUZ12 EED EZH2 | Cutis laxa |
| REAC:R-HSA-5617472 | 0.00725406490738 | 0.333333333333 | SUZ12 EED EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-5619507 | 0.00725406490738 | 0.333333333333 | SUZ12 EED EZH2 | Activation of HOX genes during differentiation |
| REAC:R-HSA-2559580 | 0.00865574339657 | 0.333333333333 | SUZ12 EED EZH2 | Oxidative Stress Induced Senescence |
| MIRNA:hsa-miR-138-5p | 0.0103654001814 | 0.333333333333 | SUZ12 EED EZH2 | hsa-miR-138-5p |
| HP:0001500 | 0.0109487743835 | 0.333333333333 | SUZ12 EED EZH2 | Broad finger |
| REAC:R-HSA-6807070 | 0.0117099375429 | 0.333333333333 | SUZ12 EED EZH2 | PTEN Regulation |
| MIRNA:hsa-miR-101-3p | 0.0120269561245 | 0.444444444444 | SUZ12 EED AEBP2 EZH2 | hsa-miR-101-3p |
| HP:0006009 | 0.0133798482859 | 0.333333333333 | SUZ12 EED EZH2 | Broad phalanx |
| HP:0001792 | 0.0138167529471 | 0.333333333333 | SUZ12 EED EZH2 | Small nail |
| HP:0005622 | 0.0166371369698 | 0.333333333333 | SUZ12 EED EZH2 | Broad long bones |
| GO:0010468 | 0.0177355061649 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | regulation of gene expression |
| HP:0008388 | 0.0203786002109 | 0.333333333333 | SUZ12 EED EZH2 | Abnormal toenail morphology |
| GO:0008213 | 0.0206245979269 | 0.444444444444 | PHF19 MTF2 JARID2 EZH2 | protein alkylation |
| GO:0006479 | 0.0206245979269 | 0.444444444444 | PHF19 MTF2 JARID2 EZH2 | protein methylation |
| HP:0000337 | 0.0215410066485 | 0.333333333333 | SUZ12 EED EZH2 | Broad forehead |
| HP:0008067 | 0.0215410066485 | 0.333333333333 | SUZ12 EED EZH2 | Abnormally lax or hyperextensible skin |
| HP:0000098 | 0.0239952052122 | 0.333333333333 | SUZ12 EED EZH2 | Tall stature |
| GO:0016570 | 0.0281315666674 | 0.555555555556 | PHF19 EPOP MTF2 JARID2 EZH2 | histone modification |
| HP:0002164 | 0.0287205613356 | 0.333333333333 | SUZ12 EED EZH2 | Nail dysplasia |
| KEGG:00310 | 0.0298422886192 | 0.222222222222 | EZH2 EZH1 | Lysine degradation |
| GO:0031062 | 0.03072093226 | 0.333333333333 | PHF19 MTF2 JARID2 | positive regulation of histone methylation |
| GO:0010605 | 0.0308900126066 | 0.888888888889 | JARID2 AEBP2 EZH1 PHF19 MTF2 SUZ12 EZH2 EED | negative regulation of macromolecule metabolic process |
| REAC:R-HSA-2559583 | 0.0313172095215 | 0.333333333333 | SUZ12 EED EZH2 | Cellular Senescence |
| HP:0009602 | 0.034020795028 | 0.333333333333 | SUZ12 EED EZH2 | Abnormality of thumb phalanx |
| GO:0016569 | 0.0351789800532 | 0.555555555556 | PHF19 EPOP MTF2 JARID2 EZH2 | covalent chromatin modification |
| HP:0009774 | 0.0364760477639 | 0.333333333333 | SUZ12 EED EZH2 | Triangular shaped phalanges of the hand |
| HP:0002866 | 0.0383405566315 | 0.222222222222 | EZH2 EED | Hypoplastic iliac wing |
| HP:0010719 | 0.0445340971924 | 0.333333333333 | SUZ12 EED EZH2 | Abnormality of hair texture |
| GO:0005654 | 0.0467384203064 | 1.0 | EPOP AEBP2 EZH1 PHF19 MTF2 SUZ12 EED EZH2 JARID2 | nucleoplasm |
| HP:0001231 | 0.0484612069102 | 0.333333333333 | SUZ12 EED EZH2 | Abnormal fingernail morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUZ12 | EZH2 | 1.0 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM hein (EZH2) Malo fraction |
| EZH2 | EED | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (EED,EZH2) Malo fraction |
| SUZ12 | EED | 0.999 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM youn_WMM hein (EED) |
| EZH2 | AEBP2 | 0.999 | 0.949 | hein_WMM bioplex (AEBP2) bioplex_WMM hein (EZH2) |
| AEBP2 | EED | 0.999 | 0.949 | hein_WMM bioplex (AEBP2) bioplex_WMM hein (EED) |
| SUZ12 | AEBP2 | 0.998 | 0.943 | hein_WMM bioplex (AEBP2,SUZ12) bioplex_WMM |
| SUZ12 | EPOP | 0.99 | 0.909 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| SUZ12 | JARID2 | 0.899 | 0.824 | hein_WMM bioplex (SUZ12) bioplex_WMM fraction |
| SUZ12 | MTF2 | 0.897 | 0.822 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| JARID2 | AEBP2 | 0.626 | 0.678 | hein_WMM bioplex (AEBP2) bioplex_WMM |
| EED | PHF19 | 0.614 | 0.674 | hein_WMM bioplex (PHF19) bioplex_WMM hein (EED) |
| SUZ12 | EZH1 | 0.5 | 0.621 | bioplex (SUZ12) bioplex_WMM |
| SUZ12 | PHF19 | 0.396 | 0.556 | hein_WMM bioplex (PHF19,SUZ12) bioplex_WMM |
| EZH2 | PHF19 | 0.347 | 0.536 | hein_WMM bioplex (PHF19) bioplex_WMM |
| EZH1 | PHF19 | 0.074 | 0.356 | bioplex (PHF19) bioplex_WMM |
| EED | MTF2 | 0.057 | 0.318 | hein_WMM bioplex_WMM hein (EED) |
| EPOP | EED | 0.012 | 0.146 | hein_WMM bioplex_WMM hein (EED) |
| EPOP | AEBP2 | 0.011 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| AEBP2 | MTF2 | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| EPOP | JARID2 | 0.01 | 0.125 | hein_WMM bioplex_WMM WMM_only |
| EZH2 | MTF2 | 0.01 | 0.121 | hein_WMM bioplex_WMM WMM_only |
| EPOP | PHF19 | 0.01 | 0.104 | hein_WMM bioplex_WMM WMM_only |
| EZH2 | EZH1 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| EED | EZH1 | 0.009 | 0.112 | bioplex_WMM WMM_only |
| AEBP2 | PHF19 | 0.009 | 0.109 | hein_WMM bioplex_WMM WMM_only |
| EPOP | MTF2 | 0.009 | 0.091 | hein_WMM bioplex_WMM WMM_only |
| JARID2 | PHF19 | 0.009 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| MTF2 | PHF19 | 0.009 | 0.097 | hein_WMM bioplex_WMM WMM_only |
| EPOP | EZH1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| JARID2 | EZH1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| JARID2 | MTF2 | 0.008 | 0.067 | hein_WMM bioplex_WMM WMM_only |
| EZH1 | MTF2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| AEBP2 | EZH1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| EZH2 | EPOP | 0.007 | 0.006 | hein_WMM bioplex_WMM hein (EZH2) |
| JARID2 | EED | 0.007 | 0.004 | hein_WMM bioplex_WMM hein (EED) |
| EZH2 | JARID2 | 0.005 | 0.009 | hein_WMM bioplex_WMM hein (EZH2) |
Images
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Complex HuMAP2_01172 has an average edge precision of 0.382 which is ranked 3507 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUZ12 | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| EPOP | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 |
| PHF19 | HuMAP2_01172 HuMAP2_01790 HuMAP2_03308 |
| MTF2 | HuMAP2_00802 HuMAP2_01172 HuMAP2_02229 |
| EZH2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| EZH1 | HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03308 |
| JARID2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |
| AEBP2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |
| EED | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |