hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01172

Confidence: Medium

Genename	Protein Name	Links
SUZ12	Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)	UniProt NCBI
EPOP	Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)	UniProt NCBI
PHF19	PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)	UniProt NCBI
MTF2	Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)	UniProt NCBI
EZH2	Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)	UniProt NCBI
EZH1	Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.43) (ENX-2) (Enhancer of zeste homolog 1)	UniProt NCBI
JARID2	Protein Jumonji (Jumonji/ARID domain-containing protein 2)	UniProt NCBI
AEBP2	Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)	UniProt NCBI
EED	Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0035098	5.76908371004e-24	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	ESC/E(Z) complex
GO:0031519	5.55585116477e-19	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	PcG protein complex
WP:WP2916	7.64743806883e-19	0.777777777778	MTF2 AEBP2 EZH1 JARID2 EED SUZ12 EZH2	Interactome of polycomb repressive complex 2 (PRC2)
GO:0035097	1.16945124732e-16	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	histone methyltransferase complex
GO:0034708	1.80810659181e-15	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	methyltransferase complex
REAC:R-HSA-212300	3.25441281204e-13	0.777777777778	MTF2 AEBP2 SUZ12 JARID2 EED PHF19 EZH2	PRC2 methylates histones and DNA
GO:0045814	3.54728221787e-12	0.888888888889	MTF2 EZH2 SUZ12 JARID2 EED EZH1 PHF19 AEBP2	negative regulation of gene expression, epigenetic
CORUM:974	1.26984090249e-11	0.444444444444	SUZ12 EZH2 EED AEBP2	EED-EZH2 complex
CORUM:7304	1.26984090249e-11	0.444444444444	PHF19 EZH2 EED SUZ12	HIC1-PCL3L-PCR2 complex
REAC:R-HSA-212165	5.30959610726e-11	0.777777777778	MTF2 AEBP2 SUZ12 JARID2 EED PHF19 EZH2	Epigenetic regulation of gene expression
CORUM:6910	6.30476064954e-09	0.333333333333	PHF19 EZH2 EED	EED-EZH2-PHF19 complex
GO:0040029	9.02741673314e-09	0.888888888889	MTF2 EZH2 SUZ12 JARID2 EED EZH1 PHF19 AEBP2	regulation of gene expression, epigenetic
GO:0003682	3.45374385605e-08	0.888888888889	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19	chromatin binding
GO:1990234	5.25719457291e-08	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	transferase complex
CORUM:105	6.30095061501e-08	0.333333333333	SUZ12 EZH2 EED	Polycomb repressive complex 2 (PRC 2)
GO:0044451	6.24729577516e-07	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	nucleoplasm part
HP:0001814	1.05890975613e-06	0.333333333333	SUZ12 EZH2 EED	Deep-set nails
WP:WP2369	2.60925915779e-06	0.444444444444	EZH1 EZH2 EED AEBP2	Histone Modifications
GO:1902494	6.70061170383e-06	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	catalytic complex
REAC:R-HSA-3214841	1.16864190892e-05	0.444444444444	SUZ12 EZH2 EED AEBP2	PKMTs methylate histone lysines
CORUM:5521	1.34129279418e-05	0.222222222222	EED EZH2	EED-EZH polycomb complex
HP:0010300	2.32467713027e-05	0.333333333333	SUZ12 EZH2 EED	Abnormally low-pitched voice
WP:WP2853	3.34361513233e-05	0.444444444444	AEBP2 MTF2 EZH2 JARID2	Endoderm Differentiation
WP:WP4204	3.67915356407e-05	0.333333333333	SUZ12 EZH2 EED	Tumor suppressor activity of SMARCB1
HP:0001816	3.84395892643e-05	0.333333333333	SUZ12 EZH2 EED	Thin nail
CORUM:7375	4.02261743042e-05	0.222222222222	SUZ12 EZH2	BRD7-EZH2-SUZ12 complex
CORUM:5502	4.02261743042e-05	0.222222222222	EED EZH2	EED-EZH-YY1 polycomb complex
CORUM:1177	4.02261743042e-05	0.222222222222	EED EZH2	Polycomb repressive complex 4
WP:WP4553	5.41611549437e-05	0.333333333333	SUZ12 EZH2 EED	FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma
GO:0046976	7.62415024416e-05	0.333333333333	SUZ12 EZH2 EED	histone methyltransferase activity (H3-K27 specific)
REAC:R-HSA-8953750	0.000180177547323	0.333333333333	SUZ12 EZH2 EED	Transcriptional Regulation by E2F6
REAC:R-HSA-74160	0.000216210898022	0.777777777778	MTF2 AEBP2 SUZ12 JARID2 EED PHF19 EZH2	Gene expression (Transcription)
GO:0006325	0.000225778327613	0.777777777778	MTF2 EZH2 PHF19 JARID2 EED EPOP EZH1	chromatin organization
HP:0001176	0.000344494666269	0.333333333333	SUZ12 EZH2 EED	Large hands
HP:0001769	0.000384127836417	0.333333333333	SUZ12 EZH2 EED	Broad foot
HP:0002002	0.000814848970559	0.333333333333	SUZ12 EZH2 EED	Deep philtrum
REAC:R-HSA-8943724	0.000874903450842	0.333333333333	SUZ12 EZH2 EED	Regulation of PTEN gene transcription
GO:0070734	0.00125570522129	0.333333333333	PHF19 EZH2 MTF2	histone H3-K27 methylation
HP:0001800	0.0013859746931	0.333333333333	SUZ12 EZH2 EED	Hypoplastic toenails
GO:0031491	0.00168817957193	0.444444444444	PHF19 EZH1 EED MTF2	nucleosome binding
REAC:R-HSA-3247509	0.00243204538797	0.444444444444	SUZ12 EZH2 EED AEBP2	Chromatin modifying enzymes
REAC:R-HSA-4839726	0.00243204538797	0.444444444444	SUZ12 EZH2 EED AEBP2	Chromatin organization
GO:0034968	0.0024605537893	0.444444444444	PHF19 EZH2 JARID2 MTF2	histone lysine methylation
HP:0005616	0.00258787460084	0.333333333333	SUZ12 EZH2 EED	Accelerated skeletal maturation
GO:0010629	0.00267198799545	0.888888888889	MTF2 EZH2 SUZ12 JARID2 EED EZH1 PHF19 AEBP2	negative regulation of gene expression
HP:0001582	0.00273634648002	0.333333333333	SUZ12 EZH2 EED	Redundant skin
WP:WP2857	0.00307359033351	0.333333333333	MTF2 JARID2 AEBP2	Mesodermal Commitment Pathway
HP:0001852	0.00321540112157	0.333333333333	SUZ12 EZH2 EED	Sandal gap
HP:0011304	0.00338662912855	0.333333333333	SUZ12 EZH2 EED	Broad thumb
WP:WP4239	0.00351999320152	0.333333333333	SUZ12 EZH2 EED	Epithelial to mesenchymal transition in colorectal cancer
HP:0001609	0.00374699276205	0.333333333333	SUZ12 EZH2 EED	Hoarse voice
HP:0002213	0.00393632560053	0.333333333333	SUZ12 EZH2 EED	Fine hair
GO:0018022	0.00500918315692	0.444444444444	PHF19 EZH2 JARID2 MTF2	peptidyl-lysine methylation
HP:0009768	0.00568358011806	0.333333333333	SUZ12 EZH2 EED	Broad phalanges of the hand
GO:0051276	0.00574740693261	0.777777777778	MTF2 EZH2 PHF19 JARID2 EED EPOP EZH1	chromosome organization
HP:0010624	0.00593252893994	0.333333333333	SUZ12 EZH2 EED	Aplastic/hypoplastic toenail
GO:0016571	0.00608964522258	0.444444444444	PHF19 EZH2 JARID2 MTF2	histone methylation
HP:0000311	0.00645186043433	0.333333333333	SUZ12 EZH2 EED	Round face
HP:0000973	0.00672243737522	0.333333333333	SUZ12 EZH2 EED	Cutis laxa
REAC:R-HSA-5617472	0.00725406490738	0.333333333333	SUZ12 EZH2 EED	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	0.00725406490738	0.333333333333	SUZ12 EZH2 EED	Activation of HOX genes during differentiation
REAC:R-HSA-2559580	0.00865574339657	0.333333333333	SUZ12 EZH2 EED	Oxidative Stress Induced Senescence
MIRNA:hsa-miR-138-5p	0.0103654001814	0.333333333333	SUZ12 EZH2 EED	hsa-miR-138-5p
HP:0001500	0.0109487743835	0.333333333333	SUZ12 EZH2 EED	Broad finger
REAC:R-HSA-6807070	0.0117099375429	0.333333333333	SUZ12 EZH2 EED	PTEN Regulation
MIRNA:hsa-miR-101-3p	0.0120269561245	0.444444444444	SUZ12 EZH2 EED AEBP2	hsa-miR-101-3p
HP:0006009	0.0133798482859	0.333333333333	SUZ12 EZH2 EED	Broad phalanx
HP:0001792	0.0138167529471	0.333333333333	SUZ12 EZH2 EED	Small nail
HP:0005622	0.0166371369698	0.333333333333	SUZ12 EZH2 EED	Broad long bones
GO:0010468	0.0177355061649	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	regulation of gene expression
HP:0008388	0.0203786002109	0.333333333333	SUZ12 EZH2 EED	Abnormal toenail morphology
GO:0008213	0.0206245979269	0.444444444444	PHF19 EZH2 JARID2 MTF2	protein alkylation
GO:0006479	0.0206245979269	0.444444444444	PHF19 EZH2 JARID2 MTF2	protein methylation
HP:0000337	0.0215410066485	0.333333333333	SUZ12 EZH2 EED	Broad forehead
HP:0008067	0.0215410066485	0.333333333333	SUZ12 EZH2 EED	Abnormally lax or hyperextensible skin
HP:0000098	0.0239952052122	0.333333333333	SUZ12 EZH2 EED	Tall stature
GO:0016570	0.0281315666674	0.555555555556	JARID2 PHF19 EZH2 EPOP MTF2	histone modification
HP:0002164	0.0287205613356	0.333333333333	SUZ12 EZH2 EED	Nail dysplasia
KEGG:00310	0.0298422886192	0.222222222222	EZH1 EZH2	Lysine degradation
GO:0031062	0.03072093226	0.333333333333	PHF19 JARID2 MTF2	positive regulation of histone methylation
GO:0010605	0.0308900126066	0.888888888889	MTF2 EZH2 SUZ12 JARID2 EED EZH1 PHF19 AEBP2	negative regulation of macromolecule metabolic process
REAC:R-HSA-2559583	0.0313172095215	0.333333333333	SUZ12 EZH2 EED	Cellular Senescence
HP:0009602	0.034020795028	0.333333333333	SUZ12 EZH2 EED	Abnormality of thumb phalanx
GO:0016569	0.0351789800532	0.555555555556	JARID2 PHF19 EZH2 EPOP MTF2	covalent chromatin modification
HP:0009774	0.0364760477639	0.333333333333	SUZ12 EZH2 EED	Triangular shaped phalanges of the hand
HP:0002866	0.0383405566315	0.222222222222	EED EZH2	Hypoplastic iliac wing
HP:0010719	0.0445340971924	0.333333333333	SUZ12 EZH2 EED	Abnormality of hair texture
GO:0005654	0.0467384203064	1.0	MTF2 EZH2 SUZ12 JARID2 EED EZH1 EPOP PHF19 AEBP2	nucleoplasm
HP:0001231	0.0484612069102	0.333333333333	SUZ12 EZH2 EED	Abnormal fingernail morphology

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SUZ12	EZH2	1.0	0.949	hein_WMM bioplex (SUZ12) bioplex_WMM hein (EZH2) Malo fraction
EZH2	EED	1.0	0.949	hein_WMM bioplex_WMM hein (EED,EZH2) Malo fraction
SUZ12	EED	0.999	0.949	hein_WMM bioplex (SUZ12) bioplex_WMM youn_WMM hein (EED)
EZH2	AEBP2	0.999	0.949	hein_WMM bioplex (AEBP2) bioplex_WMM hein (EZH2)
AEBP2	EED	0.999	0.949	hein_WMM bioplex (AEBP2) bioplex_WMM hein (EED)
SUZ12	AEBP2	0.998	0.943	hein_WMM bioplex (AEBP2,SUZ12) bioplex_WMM
SUZ12	EPOP	0.99	0.909	hein_WMM bioplex (SUZ12) bioplex_WMM
SUZ12	JARID2	0.899	0.824	hein_WMM bioplex (SUZ12) bioplex_WMM fraction
SUZ12	MTF2	0.897	0.822	hein_WMM bioplex (SUZ12) bioplex_WMM
JARID2	AEBP2	0.626	0.678	hein_WMM bioplex (AEBP2) bioplex_WMM
EED	PHF19	0.614	0.674	hein_WMM bioplex (PHF19) bioplex_WMM hein (EED)
SUZ12	EZH1	0.5	0.621	bioplex (SUZ12) bioplex_WMM
SUZ12	PHF19	0.396	0.556	hein_WMM bioplex (PHF19,SUZ12) bioplex_WMM
EZH2	PHF19	0.347	0.536	hein_WMM bioplex (PHF19) bioplex_WMM
EZH1	PHF19	0.074	0.356	bioplex (PHF19) bioplex_WMM
EED	MTF2	0.057	0.318	hein_WMM bioplex_WMM hein (EED)
EPOP	EED	0.012	0.146	hein_WMM bioplex_WMM hein (EED)
EPOP	AEBP2	0.011	0.143	hein_WMM bioplex_WMM WMM_only
AEBP2	MTF2	0.011	0.142	hein_WMM bioplex_WMM WMM_only
EPOP	JARID2	0.01	0.125	hein_WMM bioplex_WMM WMM_only
EZH2	MTF2	0.01	0.121	hein_WMM bioplex_WMM WMM_only
EPOP	PHF19	0.01	0.104	hein_WMM bioplex_WMM WMM_only
EZH2	EZH1	0.01	0.104	bioplex_WMM WMM_only
EED	EZH1	0.009	0.112	bioplex_WMM WMM_only
AEBP2	PHF19	0.009	0.109	hein_WMM bioplex_WMM WMM_only
EPOP	MTF2	0.009	0.091	hein_WMM bioplex_WMM WMM_only
JARID2	PHF19	0.009	0.09	hein_WMM bioplex_WMM WMM_only
MTF2	PHF19	0.009	0.097	hein_WMM bioplex_WMM WMM_only
EPOP	EZH1	0.008	0.091	bioplex_WMM WMM_only
JARID2	EZH1	0.008	0.085	bioplex_WMM WMM_only
JARID2	MTF2	0.008	0.067	hein_WMM bioplex_WMM WMM_only
EZH1	MTF2	0.008	0.06	bioplex_WMM WMM_only
AEBP2	EZH1	0.008	0.06	bioplex_WMM WMM_only
EZH2	EPOP	0.007	0.006	hein_WMM bioplex_WMM hein (EZH2)
JARID2	EED	0.007	0.004	hein_WMM bioplex_WMM hein (EED)
EZH2	JARID2	0.005	0.009	hein_WMM bioplex_WMM hein (EZH2)

Images

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Complex HuMAP2_01172 has an average edge precision of 0.382 which is ranked 3507 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SUZ12	HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578
EPOP	HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790
PHF19	HuMAP2_01172 HuMAP2_01790 HuMAP2_03308
MTF2	HuMAP2_00802 HuMAP2_01172 HuMAP2_02229
EZH2	HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578
EZH1	HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03308
JARID2	HuMAP2_00505 HuMAP2_01172 HuMAP2_01790
AEBP2	HuMAP2_00505 HuMAP2_01172 HuMAP2_01790
EED	HuMAP2_00505 HuMAP2_01172 HuMAP2_01790

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01172