hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01179
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MVB12A | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | UniProt NCBI |
| VPS37C | Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C) | UniProt NCBI |
| VPS37B | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | UniProt NCBI |
| TSG101 | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-174495 | 9.07805089715e-11 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| REAC:R-HSA-174490 | 9.07805089715e-11 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Membrane binding and targetting of GAG proteins |
| REAC:R-HSA-175474 | 1.65055470857e-10 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Assembly Of The HIV Virion |
| REAC:R-HSA-9615710 | 1.59160632612e-09 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Microautophagy |
| REAC:R-HSA-162588 | 1.85687404714e-09 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 2.85355515963e-09 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0000813 | 3.07384073035e-09 | 1.0 | VPS37C MVB12A TSG101 VPS37B | ESCRT I complex |
| GO:0043162 | 1.1819649475e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0039702 | 1.46007434692e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | viral budding via host ESCRT complex |
| GO:0046755 | 3.08603851103e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | viral budding |
| GO:0036452 | 3.08603851103e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | ESCRT complex |
| REAC:R-HSA-9612973 | 4.00964630173e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Autophagy |
| GO:0036258 | 6.68560358851e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | multivesicular body assembly |
| GO:0036257 | 7.6760633794e-07 | 1.0 | VPS37C MVB12A TSG101 VPS37B | multivesicular body organization |
| REAC:R-HSA-162599 | 1.12976343415e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 1.64727717851e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | HIV Life Cycle |
| GO:0019068 | 2.00655931676e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | virion assembly |
| KEGG:04144 | 2.0886994429e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Endocytosis |
| GO:0075733 | 7.71512067313e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | intracellular transport of virus |
| REAC:R-HSA-162906 | 9.09536403708e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | HIV Infection |
| GO:0046794 | 9.63649068965e-06 | 1.0 | VPS37C MVB12A TSG101 VPS37B | transport of virus |
| CORUM:1192 | 1.50819606993e-05 | 0.5 | TSG101 VPS37C | ESCRT-I complex |
| CORUM:1863 | 1.50819606993e-05 | 0.5 | VPS37B TSG101 | TSG101-VPS37B-VPS28 complex |
| GO:1902579 | 2.10899871844e-05 | 1.0 | VPS37C MVB12A TSG101 VPS37B | multi-organism localization |
| GO:0044766 | 2.10899871844e-05 | 1.0 | VPS37C MVB12A TSG101 VPS37B | multi-organism transport |
| GO:0007032 | 2.23681682258e-05 | 1.0 | VPS37C MVB12A TSG101 VPS37B | endosome organization |
| REAC:R-HSA-5663205 | 6.10347103542e-05 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Infectious disease |
| REAC:R-HSA-199991 | 0.000426145417081 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000528360370521 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Vesicle-mediated transport |
| GO:0016197 | 0.00157802566628 | 1.0 | VPS37C MVB12A TSG101 VPS37B | endosomal transport |
| REAC:R-HSA-1643685 | 0.00304553054305 | 1.0 | VPS37C MVB12A TSG101 VPS37B | Disease |
| GO:0019058 | 0.00307362739117 | 1.0 | VPS37C MVB12A TSG101 VPS37B | viral life cycle |
| GO:0016236 | 0.004264164573 | 1.0 | VPS37C MVB12A TSG101 VPS37B | macroautophagy |
| GO:0048306 | 0.00480126971785 | 0.75 | VPS37B VPS37C TSG101 | calcium-dependent protein binding |
| GO:0016050 | 0.00512711596139 | 1.0 | VPS37C MVB12A TSG101 VPS37B | vesicle organization |
| GO:0010008 | 0.00568740796512 | 1.0 | VPS37C MVB12A TSG101 VPS37B | endosome membrane |
| GO:1903774 | 0.00811409485621 | 0.5 | VPS37B TSG101 | positive regulation of viral budding via host ESCRT complex |
| GO:0044440 | 0.0096936769593 | 1.0 | VPS37C MVB12A TSG101 VPS37B | endosomal part |
| GO:0010256 | 0.0122750656924 | 1.0 | VPS37C MVB12A TSG101 VPS37B | endomembrane system organization |
| GO:1903772 | 0.0162267366884 | 0.5 | VPS37B TSG101 | regulation of viral budding via host ESCRT complex |
| GO:0006914 | 0.0243708967076 | 1.0 | VPS37C MVB12A TSG101 VPS37B | autophagy |
| GO:0061919 | 0.0243708967076 | 1.0 | VPS37C MVB12A TSG101 VPS37B | process utilizing autophagic mechanism |
| HPA:036010_23 | 0.0319520963736 | 0.75 | MVB12A VPS37C TSG101 | prostate; glandular cells[Approved,High] |
| GO:0016032 | 0.0358963427874 | 1.0 | VPS37C MVB12A TSG101 VPS37B | viral process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS37B | TSG101 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) Malo fraction |
| MVB12A | TSG101 | 0.996 | 0.927 | hein_WMM bioplex_WMM hein (TSG101) Malo fraction |
| TSG101 | VPS37C | 0.987 | 0.902 | hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) fraction |
| MVB12A | VPS37B | 0.509 | 0.629 | hein_WMM bioplex_WMM Malo fraction |
| MVB12A | VPS37C | 0.012 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| VPS37B | VPS37C | 0.009 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01179 has an average edge precision of 0.609 which is ranked 1897 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MVB12A | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_05381 HuMAP2_05909 HuMAP2_06430 |
| VPS37C | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 HuMAP2_06935 |
| VPS37B | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| TSG101 | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |