hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01183
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DYNLRB1 | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | UniProt NCBI |
| ABHD17B | Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22) | UniProt NCBI |
| DYNLT1 | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | UniProt NCBI |
| ABHD17A | Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22) | UniProt NCBI |
| CLMN | Calmin (Calponin-like transmembrane domain protein) | UniProt NCBI |
| WDR60 | WD repeat-containing protein 60 | UniProt NCBI |
| TCTEX1D2 | Tctex1 domain-containing protein 2 | UniProt NCBI |
| WDR34 | WD repeat-containing protein 34 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6236 | 3.36019899504e-13 | 0.625 | WDR60 DYNLT1 DYNLRB1 WDR34 TCTEX1D2 | Dynein-2 complex, cytoplasmic |
| WP:WP4532 | 3.73462369337e-11 | 0.625 | WDR60 DYNLT1 DYNLRB1 WDR34 TCTEX1D2 | Intraflagellar transport proteins binding to dynein |
| GO:0005868 | 7.09452923132e-09 | 0.625 | WDR60 DYNLT1 DYNLRB1 WDR34 TCTEX1D2 | cytoplasmic dynein complex |
| GO:0030286 | 3.41710904424e-07 | 0.625 | WDR60 DYNLT1 DYNLRB1 WDR34 TCTEX1D2 | dynein complex |
| REAC:R-HSA-5620924 | 1.49807683271e-06 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | Intraflagellar transport |
| WP:WP4352 | 1.52582401933e-06 | 0.625 | WDR60 DYNLT1 DYNLRB1 WDR34 TCTEX1D2 | Ciliary landscape |
| WP:WP4536 | 7.48061058091e-06 | 0.5 | WDR60 DYNLT1 WDR34 TCTEX1D2 | Genes related to primary cilium development (based on CRISPR) |
| HP:0000895 | 3.03562182961e-05 | 0.375 | WDR60 WDR34 TCTEX1D2 | Lateral clavicle hook |
| GO:0005875 | 0.000149864331431 | 0.625 | WDR60 DYNLT1 DYNLRB1 WDR34 TCTEX1D2 | microtubule associated complex |
| REAC:R-HSA-5617833 | 0.000312480655384 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | Cilium Assembly |
| GO:0042073 | 0.00038940760077 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | intraciliary transport |
| GO:0098840 | 0.000822753419149 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | protein transport along microtubule |
| GO:0099118 | 0.000822753419149 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | microtubule-based protein transport |
| REAC:R-HSA-1852241 | 0.00140977665905 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | Organelle biogenesis and maintenance |
| HP:0010480 | 0.00248871678952 | 0.25 | WDR60 WDR34 | Urethral fistula |
| HP:0008716 | 0.00248871678952 | 0.25 | WDR60 WDR34 | Urethrovaginal fistula |
| HP:0006644 | 0.00248871678952 | 0.25 | WDR60 WDR34 | Thoracic dysplasia |
| HP:0010564 | 0.00348326758344 | 0.25 | WDR60 WDR34 | Bifid epiglottis |
| HP:0003762 | 0.00464310919637 | 0.25 | WDR60 WDR34 | Uterus didelphys |
| HP:0005716 | 0.00745813121128 | 0.25 | WDR60 WDR34 | Lethal skeletal dysplasia |
| HP:0000889 | 0.00905007554403 | 0.375 | WDR60 WDR34 TCTEX1D2 | Abnormality of the clavicle |
| HP:0009106 | 0.00911304494741 | 0.25 | WDR60 WDR34 | Abnormal pelvis bone ossification |
| HP:0000774 | 0.00933965286747 | 0.375 | WDR60 WDR34 TCTEX1D2 | Narrow chest |
| HP:0004599 | 0.0109327161708 | 0.25 | WDR60 WDR34 | Absent or minimally ossified vertebral bodies |
| HP:0005483 | 0.0129170117165 | 0.25 | WDR60 WDR34 | Abnormal epiglottis morphology |
| HP:0002006 | 0.0129170117165 | 0.25 | WDR60 WDR34 | Facial cleft |
| HP:0005257 | 0.0140576912232 | 0.375 | WDR60 WDR34 TCTEX1D2 | Thoracic hypoplasia |
| GO:0010970 | 0.0183007736638 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | transport along microtubule |
| HP:0100569 | 0.0224977761754 | 0.25 | WDR60 WDR34 | Abnormally ossified vertebrae |
| GO:0099111 | 0.0284637816739 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | microtubule-based transport |
| GO:0030705 | 0.0353535361387 | 0.5 | WDR60 WDR34 DYNLRB1 TCTEX1D2 | cytoskeleton-dependent intracellular transport |
| GO:0031021 | 0.0378589948753 | 0.25 | WDR60 TCTEX1D2 | interphase microtubule organizing center |
| HP:0002032 | 0.0381618271547 | 0.25 | WDR60 WDR34 | Esophageal atresia |
| HP:0010297 | 0.0381618271547 | 0.25 | WDR60 WDR34 | Bifid tongue |
| GO:0034613 | 0.0398294539613 | 0.875 | TCTEX1D2 WDR60 DYNLT1 DYNLRB1 WDR34 CLMN ABHD17A | cellular protein localization |
| GO:0070727 | 0.0414994148133 | 0.875 | TCTEX1D2 WDR60 DYNLT1 DYNLRB1 WDR34 CLMN ABHD17A | cellular macromolecule localization |
| HP:0004320 | 0.0417850566195 | 0.25 | WDR60 WDR34 | Vaginal fistula |
| GO:0035735 | 0.0497817121827 | 0.375 | WDR60 DYNLRB1 WDR34 | intraciliary transport involved in cilium assembly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR60 | TCTEX1D2 | 0.98 | 0.896 | bioplex (TCTEX1D2) bioplex_WMM boldt (TCTEX1D2,WDR60) gupta_WMM boldt_WMM |
| TCTEX1D2 | DYNLT1 | 0.912 | 0.835 | bioplex_WMM gupta (DYNLT1) boldt (DYNLT1,TCTEX1D2) gupta_WMM boldt_WMM |
| DYNLT1 | WDR34 | 0.857 | 0.794 | bioplex (WDR34) bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) gupta_WMM boldt_WMM |
| WDR34 | DYNLRB1 | 0.771 | 0.75 | hein_WMM bioplex (WDR34) bioplex_WMM boldt (WDR34) hein (DYNLRB1) gupta_WMM boldt_WMM |
| DYNLT1 | DYNLRB1 | 0.7 | 0.722 | hein_WMM bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) gupta_WMM boldt_WMM |
| WDR60 | DYNLT1 | 0.344 | 0.534 | bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) gupta_WMM boldt_WMM |
| TCTEX1D2 | ABHD17A | 0.296 | 0.496 | bioplex (ABHD17A) bioplex_WMM |
| TCTEX1D2 | WDR34 | 0.254 | 0.478 | bioplex (TCTEX1D2) bioplex_WMM boldt (TCTEX1D2,WDR34) gupta_WMM boldt_WMM |
| WDR60 | DYNLRB1 | 0.219 | 0.465 | hein_WMM bioplex_WMM boldt hein (DYNLRB1) gupta_WMM boldt_WMM |
| TCTEX1D2 | CLMN | 0.175 | 0.435 | bioplex (TCTEX1D2) bioplex_WMM |
| WDR60 | WDR34 | 0.057 | 0.324 | hein_WMM bioplex_WMM boldt (WDR34,WDR60) gupta_WMM boldt_WMM |
| TCTEX1D2 | ABHD17B | 0.045 | 0.282 | bioplex (TCTEX1D2) bioplex_WMM boldt (TCTEX1D2) boldt_WMM |
| TCTEX1D2 | DYNLRB1 | 0.013 | 0.144 | bioplex_WMM boldt (TCTEX1D2) gupta_WMM boldt_WMM |
| WDR60 | CLMN | 0.008 | 0.095 | bioplex_WMM WMM_only |
| CLMN | WDR34 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| ABHD17B | ABHD17A | 0.007 | 0.008 | bioplex_WMM WMM_only |
| CLMN | ABHD17B | 0.007 | 0.004 | bioplex_WMM WMM_only |
| WDR60 | ABHD17B | 0.007 | 0.006 | bioplex_WMM boldt boldt_WMM |
| CLMN | DYNLRB1 | 0.007 | 0.002 | youn_WMM WMM_only |
| ABHD17B | WDR34 | 0.007 | 0.001 | bioplex_WMM boldt boldt_WMM |
| CLMN | DYNLT1 | 0.007 | 0.0 | youn_WMM WMM_only |
| DYNLT1 | ABHD17A | 0.007 | 0.0 | bioplex_WMM WMM_only |
| ABHD17B | DYNLRB1 | 0.007 | 0.004 | bioplex_WMM boldt boldt_WMM |
| DYNLRB1 | ABHD17A | 0.006 | 0.002 | bioplex (ABHD17A) bioplex_WMM |
| ABHD17B | DYNLT1 | 0.006 | 0.007 | bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_01183 has an average edge precision of 0.294 which is ranked 4685 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DYNLRB1 | HuMAP2_01183 HuMAP2_03026 HuMAP2_04880 |
| ABHD17B | HuMAP2_01183 HuMAP2_01932 HuMAP2_04880 HuMAP2_06863 |
| DYNLT1 | HuMAP2_01183 HuMAP2_03026 HuMAP2_04880 |
| ABHD17A | HuMAP2_01183 HuMAP2_01932 HuMAP2_02909 HuMAP2_06863 |
| CLMN | HuMAP2_01183 HuMAP2_01932 HuMAP2_04880 HuMAP2_06863 |
| WDR60 | HuMAP2_01183 HuMAP2_04167 HuMAP2_04880 |
| TCTEX1D2 | HuMAP2_01183 HuMAP2_01932 HuMAP2_04167 HuMAP2_04880 HuMAP2_06863 |
| WDR34 | HuMAP2_01183 HuMAP2_03026 HuMAP2_04880 |