hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01188

Confidence: Medium High

Genename	Protein Name	Links
PDHA2	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	UniProt NCBI
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	UniProt NCBI
PDK4	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	1.07132757975e-13	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Regulation of pyruvate dehydrogenase (PDH) complex
REAC:R-HSA-70268	2.91267185745e-12	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Pyruvate metabolism
REAC:R-HSA-5362517	1.6138784755e-11	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Signaling by Retinoic Acid
REAC:R-HSA-71406	6.37439909952e-11	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0004740	1.2197780676e-10	0.8	PDK2 PDK4 PDK1 PDK3	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0050812	8.53661148134e-09	0.8	PDK2 PDK4 PDK1 PDK3	regulation of acyl-CoA biosynthetic process
GO:0010510	8.53661148134e-09	0.8	PDK2 PDK4 PDK1 PDK3	regulation of acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-1428517	2.3513360199e-08	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	The citric acid (TCA) cycle and respiratory electron transport
GO:0051196	2.56070819562e-08	0.8	PDK2 PDK4 PDK1 PDK3	regulation of coenzyme metabolic process
GO:0042762	2.56070819562e-08	0.8	PDK2 PDK4 PDK1 PDK3	regulation of sulfur metabolic process
GO:0006086	6.03530623185e-08	0.8	PDK2 PDK4 PDK1 PDK3	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-9006931	1.69628241468e-07	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Signaling by Nuclear Receptors
GO:0006085	2.90104413489e-07	0.8	PDK2 PDK4 PDK1 PDK3	acetyl-CoA biosynthetic process
GO:0051193	7.29370383293e-07	0.8	PDK2 PDK4 PDK1 PDK3	regulation of cofactor metabolic process
GO:1900371	8.91404751529e-07	0.8	PDK2 PDK4 PDK1 PDK3	regulation of purine nucleotide biosynthetic process
GO:0030808	1.07901087813e-06	0.8	PDK2 PDK4 PDK1 PDK3	regulation of nucleotide biosynthetic process
GO:0006084	1.82141275099e-06	0.8	PDK2 PDK4 PDK1 PDK3	acetyl-CoA metabolic process
GO:0006090	1.92126330028e-06	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	pyruvate metabolic process
GO:0035384	1.36251014669e-05	0.8	PDK2 PDK4 PDK1 PDK3	thioester biosynthetic process
GO:0071616	1.36251014669e-05	0.8	PDK2 PDK4 PDK1 PDK3	acyl-CoA biosynthetic process
GO:0019217	4.46760620155e-05	0.8	PDK2 PDK4 PDK1 PDK3	regulation of fatty acid metabolic process
GO:0034033	4.46760620155e-05	0.8	PDK2 PDK4 PDK1 PDK3	purine nucleoside bisphosphate biosynthetic process
GO:0034030	4.46760620155e-05	0.8	PDK2 PDK4 PDK1 PDK3	ribonucleoside bisphosphate biosynthetic process
GO:0033866	4.46760620155e-05	0.8	PDK2 PDK4 PDK1 PDK3	nucleoside bisphosphate biosynthetic process
GO:0010906	6.78326696841e-05	0.8	PDK2 PDK4 PDK1 PDK3	regulation of glucose metabolic process
GO:0010675	0.000173300430897	0.8	PDK2 PDK4 PDK1 PDK3	regulation of cellular carbohydrate metabolic process
GO:0006637	0.000192129923302	0.8	PDK2 PDK4 PDK1 PDK3	acyl-CoA metabolic process
GO:0035383	0.000192129923302	0.8	PDK2 PDK4 PDK1 PDK3	thioester metabolic process
GO:1900542	0.000257885403211	0.8	PDK2 PDK4 PDK1 PDK3	regulation of purine nucleotide metabolic process
GO:0006140	0.000283155128059	0.8	PDK2 PDK4 PDK1 PDK3	regulation of nucleotide metabolic process
WP:WP4206	0.000632959696686	0.4	PDHA2 PDK1	Hereditary leiomyomatosis and renal cell carcinoma pathway
GO:0033865	0.000700189954213	0.8	PDK2 PDK4 PDK1 PDK3	nucleoside bisphosphate metabolic process
GO:0033875	0.000700189954213	0.8	PDK2 PDK4 PDK1 PDK3	ribonucleoside bisphosphate metabolic process
GO:0034032	0.000700189954213	0.8	PDK2 PDK4 PDK1 PDK3	purine nucleoside bisphosphate metabolic process
GO:0005759	0.000762366516291	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	mitochondrial matrix
GO:0009108	0.000868135384463	0.8	PDK2 PDK4 PDK1 PDK3	coenzyme biosynthetic process
GO:0009152	0.00106458629457	0.8	PDK2 PDK4 PDK1 PDK3	purine ribonucleotide biosynthetic process
GO:0006006	0.00110031121064	0.8	PDK2 PDK4 PDK1 PDK3	glucose metabolic process
GO:0009260	0.00133388073681	0.8	PDK2 PDK4 PDK1 PDK3	ribonucleotide biosynthetic process
GO:0010565	0.00146369592834	0.8	PDK2 PDK4 PDK1 PDK3	regulation of cellular ketone metabolic process
GO:0006109	0.0016027516158	0.8	PDK2 PDK4 PDK1 PDK3	regulation of carbohydrate metabolic process
GO:0006164	0.0016027516158	0.8	PDK2 PDK4 PDK1 PDK3	purine nucleotide biosynthetic process
GO:0046390	0.0016027516158	0.8	PDK2 PDK4 PDK1 PDK3	ribose phosphate biosynthetic process
GO:0032787	0.00166813062683	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	monocarboxylic acid metabolic process
GO:0072522	0.00219868446227	0.8	PDK2 PDK4 PDK1 PDK3	purine-containing compound biosynthetic process
GO:0019318	0.00265571901763	0.8	PDK2 PDK4 PDK1 PDK3	hexose metabolic process
GO:0044272	0.00279846120143	0.8	PDK2 PDK4 PDK1 PDK3	sulfur compound biosynthetic process
GO:0044262	0.00351311547176	0.8	PDK2 PDK4 PDK1 PDK3	cellular carbohydrate metabolic process
GO:0042180	0.00466856734611	0.8	PDK2 PDK4 PDK1 PDK3	cellular ketone metabolic process
REAC:R-HSA-1430728	0.00473657209702	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Metabolism
GO:0051188	0.0049971900723	0.8	PDK2 PDK4 PDK1 PDK3	cofactor biosynthetic process
GO:0009165	0.00511048538005	0.8	PDK2 PDK4 PDK1 PDK3	nucleotide biosynthetic process
GO:0005996	0.00583116822137	0.8	PDK2 PDK4 PDK1 PDK3	monosaccharide metabolic process
REAC:R-HSA-162582	0.00595743543191	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	Signal Transduction
GO:1901293	0.00608750012464	0.8	PDK2 PDK4 PDK1 PDK3	nucleoside phosphate biosynthetic process
GO:0006732	0.00749792730182	0.8	PDK2 PDK4 PDK1 PDK3	coenzyme metabolic process
KEGG:05230	0.00941045001151	0.4	PDHA2 PDK1	Central carbon metabolism in cancer
GO:0097411	0.0135228859698	0.4	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
KEGG:04066	0.020974746694	0.4	PDHA2 PDK1	HIF-1 signaling pathway
GO:0044429	0.0210056852384	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	mitochondrial part
GO:0006631	0.0227281670195	0.8	PDK2 PDK4 PDK1 PDK3	fatty acid metabolic process
GO:0019752	0.0246974667253	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	carboxylic acid metabolic process
GO:0019216	0.0292681328876	0.8	PDK2 PDK4 PDK1 PDK3	regulation of lipid metabolic process
GO:0009150	0.0361255742156	0.8	PDK2 PDK4 PDK1 PDK3	purine ribonucleotide metabolic process
GO:0034248	0.0371232263042	0.8	PDK2 PDK4 PDK1 PDK3	regulation of cellular amide metabolic process
GO:0043436	0.0374817807184	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	oxoacid metabolic process
GO:0006790	0.0376297096835	0.8	PDK2 PDK4 PDK1 PDK3	sulfur compound metabolic process
GO:0062012	0.0402400813039	0.8	PDK2 PDK4 PDK1 PDK3	regulation of small molecule metabolic process
GO:0006082	0.0403101804931	1.0	PDK2 PDK3 PDK4 PDHA2 PDK1	organic acid metabolic process
GO:0009259	0.0407779900821	0.8	PDK2 PDK4 PDK1 PDK3	ribonucleotide metabolic process
GO:0019693	0.0452771886593	0.8	PDK2 PDK4 PDK1 PDK3	ribose phosphate metabolic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PDHA2	PDK3	1.0	0.949	bioplex (PDK3) bioplex_WMM
PDK1	PDK2	1.0	0.949	hein_WMM bioplex (PDK1) bioplex_WMM hein (PDK1)
PDK3	PDK1	1.0	0.949	hein_WMM bioplex (PDK1,PDK3) bioplex_WMM youn_WMM hein (PDK1)
PDK3	PDK2	0.444	0.588	hein_WMM bioplex (PDK3) bioplex_WMM
PDK2	PDK4	0.128	0.399	bioplex (PDK4) bioplex_WMM
PDK3	PDK4	0.027	0.228	bioplex (PDK4) bioplex_WMM
PDK1	PDK4	0.022	0.205	bioplex (PDK4) bioplex_WMM
PDHA2	PDK2	0.008	0.037	bioplex_WMM WMM_only
PDHA2	PDK1	0.008	0.027	bioplex_WMM WMM_only

Images

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Complex HuMAP2_01188 has an average edge precision of 0.481 which is ranked 2624 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PDHA2	HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06120 HuMAP2_06177
PDK1	HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_03608
PDK2	HuMAP2_01188 HuMAP2_02908 HuMAP2_03608
PDK3	HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086
PDK4	HuMAP2_01188 HuMAP2_02908

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01188