hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01189
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD99L2 | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | UniProt NCBI |
| TRIP12 | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | UniProt NCBI |
| CAPNS2 | Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8862803 | 7.16758219917e-09 | 0.666666666667 | CAPN1 CAPNS2 CAST CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 7.16758219917e-09 | 0.666666666667 | CAPN1 CAPNS2 CAST CAPNS1 | Neurodegenerative Diseases |
| CORUM:6710 | 8.39001385941e-06 | 0.333333333333 | CAPNS1 CAPN1 | Calpain 1 |
| REAC:R-HSA-1474228 | 1.26293159301e-05 | 0.666666666667 | CAPN1 CAPNS2 CAST CAPNS1 | Degradation of the extracellular matrix |
| REAC:R-HSA-1474244 | 0.000241421592823 | 0.666666666667 | CAPN1 CAPNS2 CAST CAPNS1 | Extracellular matrix organization |
| GO:0004198 | 0.000518697707158 | 0.5 | CAPNS2 CAPNS1 CAPN1 | calcium-dependent cysteine-type endopeptidase activity |
| WP:WP185 | 0.0235215924424 | 0.333333333333 | CAPNS1 CAPN1 | Integrin-mediated Cell Adhesion |
| REAC:R-HSA-1643685 | 0.0363076318173 | 0.666666666667 | CAPN1 CAPNS2 CAST CAPNS1 | Disease |
| CORUM:6706 | 0.0499726005494 | 0.166666666667 | CAPN1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAPN1 | CAST | 1.0 | 0.949 | hein_WMM bioplex (CAPN1) bioplex_WMM youn_WMM hein (CAPN1) |
| CD99L2 | CAPN1 | 0.997 | 0.93 | bioplex (CAPN1) bioplex_WMM |
| CAPNS1 | CAPN1 | 0.992 | 0.912 | hein_WMM bioplex (CAPN1) bioplex_WMM hein (CAPN1) |
| CAST | CAPNS2 | 0.991 | 0.909 | bioplex (CAPNS2) bioplex_WMM |
| CAPN1 | CAPNS2 | 0.616 | 0.675 | bioplex (CAPN1,CAPNS2) bioplex_WMM |
| TRIP12 | CAPN1 | 0.527 | 0.634 | bioplex (CAPN1) bioplex_WMM youn_WMM |
| CAPNS1 | CAST | 0.013 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| CAPNS1 | CAPNS2 | 0.013 | 0.154 | bioplex (CAPNS2) bioplex_WMM |
| CD99L2 | CAST | 0.008 | 0.085 | bioplex_WMM WMM_only |
| TRIP12 | CD99L2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CD99L2 | CAPNS2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| CAPNS1 | CD99L2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| TRIP12 | CAST | 0.008 | 0.013 | bioplex_WMM youn_WMM WMM_only |
| TRIP12 | CAPNS2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| TRIP12 | CAPNS1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01189 has an average edge precision of 0.372 which is ranked 3620 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CD99L2 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| TRIP12 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02830 |
| CAPNS1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| CAPN1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 HuMAP2_05795 |
| CAST | HuMAP2_01189 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |
| CAPNS2 | HuMAP2_01189 HuMAP2_01317 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |