hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01198
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN2B | Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) | UniProt NCBI |
| CDK6 | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | UniProt NCBI |
| CDKN2D | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2559585 | 2.23000067859e-06 | 1.0 | CDKN2D CDK6 CDKN2B | Oncogene Induced Senescence |
| WP:WP45 | 2.55779891663e-06 | 1.0 | CDKN2D CDK6 CDKN2B | G1 to S cell cycle control |
| REAC:R-HSA-69231 | 5.16137253834e-06 | 1.0 | CDKN2D CDK6 CDKN2B | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 5.16137253834e-06 | 1.0 | CDKN2D CDK6 CDKN2B | G1 Phase |
| KEGG:04110 | 8.44552612263e-06 | 1.0 | CDKN2D CDK6 CDKN2B | Cell cycle |
| WP:WP179 | 1.63254441694e-05 | 1.0 | CDKN2D CDK6 CDKN2B | Cell Cycle |
| REAC:R-HSA-2559582 | 8.67362360712e-05 | 1.0 | CDKN2D CDK6 CDKN2B | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-2559580 | 0.000132738992005 | 1.0 | CDKN2D CDK6 CDKN2B | Oxidative Stress Induced Senescence |
| REAC:R-HSA-453279 | 0.000233190181847 | 1.0 | CDKN2D CDK6 CDKN2B | Mitotic G1-G1/S phases |
| REAC:R-HSA-2559583 | 0.000489986899103 | 1.0 | CDKN2D CDK6 CDKN2B | Cellular Senescence |
| WP:WP3998 | 0.000905695914221 | 0.666666666667 | CDKN2B CDK6 | Prader-Willi and Angelman Syndrome |
| KEGG:05222 | 0.00186709616111 | 0.666666666667 | CDKN2B CDK6 | Small cell lung cancer |
| KEGG:04068 | 0.00287006078872 | 0.666666666667 | CDKN2D CDKN2B | FoxO signaling pathway |
| WP:WP2261 | 0.00317409068183 | 0.666666666667 | CDKN2B CDK6 | Signaling Pathways in Glioblastoma |
| WP:WP4658 | 0.00426499169434 | 0.666666666667 | CDKN2B CDK6 | Small cell lung cancer |
| KEGG:04934 | 0.00439265454468 | 0.666666666667 | CDKN2B CDK6 | Cushing syndrome |
| KEGG:04218 | 0.00464549646756 | 0.666666666667 | CDKN2B CDK6 | Cellular senescence |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | CDKN2D CDK6 CDKN2B | Cellular responses to stress |
| WP:WP2877 | 0.00763160358706 | 0.666666666667 | CDKN2D CDKN2B | Vitamin D Receptor Pathway |
| KEGG:05203 | 0.00780654538689 | 0.666666666667 | CDKN2B CDK6 | Viral carcinogenesis |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | CDKN2D CDK6 CDKN2B | Cellular responses to external stimuli |
| GO:2000134 | 0.00962631496557 | 1.0 | CDKN2D CDK6 CDKN2B | negative regulation of G1/S transition of mitotic cell cycle |
| GO:1902807 | 0.00996606725847 | 1.0 | CDKN2D CDK6 CDKN2B | negative regulation of cell cycle G1/S phase transition |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | CDKN2D CDK6 CDKN2B | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | CDKN2D CDK6 CDKN2B | Cell Cycle |
| GO:2000045 | 0.0248678516681 | 1.0 | CDKN2D CDK6 CDKN2B | regulation of G1/S transition of mitotic cell cycle |
| MIRNA:hsa-miR-7855-5p | 0.0317827062049 | 0.666666666667 | CDKN2B CDK6 | hsa-miR-7855-5p |
| GO:1902806 | 0.032491253758 | 1.0 | CDKN2D CDK6 CDKN2B | regulation of cell cycle G1/S phase transition |
| WP:WP2249 | 0.0428416541517 | 0.333333333333 | CDK6 | Metastatic brain tumor |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | CDKN2B CDK6 | Pathways in cancer |
| GO:0004861 | 0.0486736709081 | 0.666666666667 | CDKN2D CDKN2B | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| CORUM:3087 | 0.0499776345577 | 0.333333333333 | CDK6 | CCND1-CDK6 complex |
| CORUM:3088 | 0.0499776345577 | 0.333333333333 | CDK6 | CCND2-CDK6 complex |
| CORUM:3089 | 0.0499776345577 | 0.333333333333 | CDK6 | CCND3-CDK6 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN2B | CDK6 | 0.877 | 0.811 | bioplex (CDK6) bioplex_WMM |
| CDKN2D | CDK6 | 0.161 | 0.417 | bioplex (CDK6) bioplex_WMM |
| CDKN2B | CDKN2D | 0.013 | 0.149 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01198 has an average edge precision of 0.459 which is ranked 2809 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN2B | HuMAP2_01131 HuMAP2_01198 HuMAP2_03365 HuMAP2_06643 |
| CDK6 | HuMAP2_01198 HuMAP2_03365 HuMAP2_04118 HuMAP2_06643 |
| CDKN2D | HuMAP2_01198 HuMAP2_04118 HuMAP2_06643 |