hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01201
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LRP10 | Low-density lipoprotein receptor-related protein 10 (LRP-10) | UniProt NCBI |
| BMPR1A | Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) | UniProt NCBI |
| ACVR2A | Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) | UniProt NCBI |
| FMN2 | Formin-2 | UniProt NCBI |
| ACVR2B | Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) | UniProt NCBI |
| TGFBR2 | TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04350 | 4.79476375504e-07 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | TGF-beta signaling pathway |
| GO:0004675 | 4.98908875278e-07 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | transmembrane receptor protein serine/threonine kinase activity |
| REAC:R-HSA-9006936 | 2.90272483296e-06 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | Signaling by TGF-beta family members |
| KEGG:04060 | 8.7605482185e-06 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | Cytokine-cytokine receptor interaction |
| REAC:R-HSA-201451 | 1.05150257754e-05 | 0.5 | ACVR2B BMPR1A ACVR2A | Signaling by BMP |
| GO:0017002 | 0.000101639975642 | 0.5 | ACVR2B ACVR2A TGFBR2 | activin-activated receptor activity |
| GO:0048185 | 0.000217734118711 | 0.5 | ACVR2B ACVR2A TGFBR2 | activin binding |
| GO:0019199 | 0.000352998651013 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | transmembrane receptor protein kinase activity |
| KEGG:04550 | 0.000499786319182 | 0.5 | ACVR2B BMPR1A ACVR2A | Signaling pathways regulating pluripotency of stem cells |
| WP:WP2857 | 0.000514730576428 | 0.5 | ACVR2B BMPR1A ACVR2A | Mesodermal Commitment Pathway |
| KEGG:05418 | 0.000524612840052 | 0.5 | ACVR2B BMPR1A ACVR2A | Fluid shear stress and atherosclerosis |
| WP:WP3874 | 0.000585450803921 | 0.333333333333 | BMPR1A TGFBR2 | Canonical and Non-Canonical TGF-B signaling |
| REAC:R-HSA-1433617 | 0.000797179114843 | 0.333333333333 | ACVR2B ACVR2A | Regulation of signaling by NODAL |
| REAC:R-HSA-1502540 | 0.000797179114843 | 0.333333333333 | ACVR2B ACVR2A | Signaling by Activin |
| REAC:R-HSA-1181150 | 0.00265393377546 | 0.333333333333 | ACVR2B ACVR2A | Signaling by NODAL |
| GO:0030501 | 0.00529364410104 | 0.5 | ACVR2B BMPR1A ACVR2A | positive regulation of bone mineralization |
| GO:0090092 | 0.0061921234234 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| HP:0100571 | 0.00682280818411 | 0.333333333333 | BMPR1A TGFBR2 | Cardiac diverticulum |
| GO:0110151 | 0.00813009778332 | 0.5 | ACVR2B BMPR1A ACVR2A | positive regulation of biomineralization |
| GO:0070169 | 0.00813009778332 | 0.5 | ACVR2B BMPR1A ACVR2A | positive regulation of biomineral tissue development |
| GO:0045669 | 0.00986527098502 | 0.5 | ACVR2B BMPR1A ACVR2A | positive regulation of osteoblast differentiation |
| HP:0012174 | 0.0128094019441 | 0.333333333333 | BMPR1A TGFBR2 | Glioblastoma multiforme |
| HP:0100660 | 0.0163927867751 | 0.5 | FMN2 BMPR1A TGFBR2 | Dyskinesia |
| HP:0006725 | 0.0224484879882 | 0.333333333333 | BMPR1A TGFBR2 | Pancreatic adenocarcinoma |
| GO:0030500 | 0.0239073169747 | 0.5 | ACVR2B BMPR1A ACVR2A | regulation of bone mineralization |
| CORUM:3041 | 0.0249904952816 | 0.166666666667 | TGFBR2 | TGF-beta-receptor type II homodimer complex |
| CORUM:3042 | 0.0249904952816 | 0.166666666667 | TGFBR2 | TGF-beta receptor II-TGF-beta1 complex |
| CORUM:3026 | 0.0249904952816 | 0.166666666667 | TGFBR2 | TGF-beta receptor II-TGF-beta1 complex |
| HP:0010524 | 0.0262553193116 | 0.333333333333 | BMPR1A TGFBR2 | Agnosia |
| HP:0002893 | 0.0262553193116 | 0.333333333333 | BMPR1A TGFBR2 | Pituitary adenoma |
| GO:0007178 | 0.0287203705471 | 0.666666666667 | ACVR2B TGFBR2 BMPR1A ACVR2A | transmembrane receptor protein serine/threonine kinase signaling pathway |
| GO:0045778 | 0.0292571070793 | 0.5 | ACVR2B BMPR1A ACVR2A | positive regulation of ossification |
| HP:0006749 | 0.034757762481 | 0.333333333333 | BMPR1A TGFBR2 | Malignant gastrointestinal tract tumors |
| HP:0002672 | 0.034757762481 | 0.333333333333 | BMPR1A TGFBR2 | Gastrointestinal carcinoma |
| REAC:R-HSA-162582 | 0.0348492364063 | 0.833333333333 | LRP10 ACVR2A BMPR1A TGFBR2 ACVR2B | Signal Transduction |
| HP:0100576 | 0.0370683023611 | 0.333333333333 | BMPR1A TGFBR2 | Amaurosis fugax |
| GO:0060389 | 0.0375522887938 | 0.5 | TGFBR2 BMPR1A ACVR2A | pathway-restricted SMAD protein phosphorylation |
| HP:0100743 | 0.0394527338604 | 0.333333333333 | BMPR1A TGFBR2 | Neoplasm of the rectum |
| HP:0011750 | 0.0394527338604 | 0.333333333333 | BMPR1A TGFBR2 | Neoplasm of the anterior pituitary |
| HP:0040277 | 0.0394527338604 | 0.333333333333 | BMPR1A TGFBR2 | Neoplasm of the pituitary gland |
| HP:0009733 | 0.0419110169922 | 0.333333333333 | BMPR1A TGFBR2 | Glioma |
| HP:0003006 | 0.0470489782673 | 0.333333333333 | BMPR1A TGFBR2 | Neuroblastoma |
| HP:0004376 | 0.0470489782673 | 0.333333333333 | BMPR1A TGFBR2 | Neuroblastic tumor |
| HP:0030067 | 0.0470489782673 | 0.333333333333 | BMPR1A TGFBR2 | Peripheral primitive neuroectodermal neoplasm |
| HP:0010526 | 0.0497285764978 | 0.333333333333 | BMPR1A TGFBR2 | Dysgraphia |
| HP:0003003 | 0.0497285764978 | 0.333333333333 | BMPR1A TGFBR2 | Colon cancer |
| CORUM:3025 | 0.0499726005494 | 0.166666666667 | TGFBR2 | TGF-beta receptor II-TGF-beta3 complex |
| CORUM:3043 | 0.0499726005494 | 0.166666666667 | BMPR1A | BMP2-BRIA complex |
| CORUM:6234 | 0.0499726005494 | 0.166666666667 | TGFBR2 | TGF-betaR2-TGF-beta3 complex |
| CORUM:3031 | 0.0499726005494 | 0.166666666667 | TGFBR2 | Microprocessor complex |
| CORUM:3027 | 0.0499726005494 | 0.166666666667 | TGFBR2 | TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACVR2A | TGFBR2 | 0.169 | 0.426 | bioplex (TGFBR2) bioplex_WMM |
| FMN2 | TGFBR2 | 0.041 | 0.271 | bioplex (TGFBR2) bioplex_WMM |
| BMPR1A | TGFBR2 | 0.039 | 0.264 | bioplex (TGFBR2) bioplex_WMM |
| BMPR1A | LRP10 | 0.031 | 0.237 | hein_WMM bioplex_WMM hein (BMPR1A) |
| ACVR2B | TGFBR2 | 0.022 | 0.207 | bioplex (TGFBR2) bioplex_WMM |
| BMPR1A | ACVR2A | 0.014 | 0.141 | bioplex_WMM WMM_only |
| ACVR2B | ACVR2A | 0.01 | 0.137 | bioplex_WMM WMM_only |
| ACVR2B | BMPR1A | 0.009 | 0.098 | bioplex_WMM WMM_only |
| LRP10 | ACVR2A | 0.008 | 0.089 | bioplex_WMM WMM_only |
| FMN2 | ACVR2A | 0.007 | 0.0 | bioplex_WMM WMM_only |
| ACVR2B | FMN2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| FMN2 | LRP10 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ACVR2B | LRP10 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| FMN2 | BMPR1A | 0.007 | 0.005 | bioplex_WMM WMM_only |
| LRP10 | TGFBR2 | 0.0 | 0.014 | bioplex (TGFBR2) bioplex_WMM |
Images
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Complex HuMAP2_01201 has an average edge precision of 0.127 which is ranked 6844 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LRP10 | HuMAP2_01201 HuMAP2_04960 |
| BMPR1A | HuMAP2_01201 HuMAP2_04960 |
| ACVR2A | HuMAP2_01201 HuMAP2_06934 |
| FMN2 | HuMAP2_01201 HuMAP2_06934 |
| ACVR2B | HuMAP2_01170 HuMAP2_01201 HuMAP2_02689 HuMAP2_04527 HuMAP2_05763 |
| TGFBR2 | HuMAP2_01201 HuMAP2_06934 |