hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01219
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 3.51943927099e-05 | 1.0 | TEAD2 TEAD4 | RUNX3 regulates YAP1-mediated transcription |
| WP:WP3967 | 4.47097598062e-05 | 1.0 | TEAD2 TEAD4 | miR-509-3p alteration of YAP1/ECM axis |
| KEGG:04392 | 4.7416701844e-05 | 1.0 | TEAD2 TEAD4 | Hippo signaling pathway - multiple species |
| WP:WP4533 | 5.70049437529e-05 | 1.0 | TEAD2 TEAD4 | Transcription co-factors SKI and SKIL protein partners |
| WP:WP4537 | 7.07904530264e-05 | 1.0 | TEAD2 TEAD4 | Hippo-Yap signaling pathway |
| REAC:R-HSA-2032785 | 0.000152509035076 | 1.0 | TEAD2 TEAD4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4542 | 0.000162072879297 | 1.0 | TEAD2 TEAD4 | Overview of leukocyte-intrinsic Hippo pathway functions |
| WP:WP4534 | 0.000305516692009 | 1.0 | TEAD2 TEAD4 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP4540 | 0.00139382676196 | 1.0 | TEAD2 TEAD4 | Pathways Regulating Hippo Signaling |
| KEGG:04390 | 0.00146058031434 | 1.0 | TEAD2 TEAD4 | Hippo signaling pathway |
| WP:WP4541 | 0.00191916643968 | 1.0 | TEAD2 TEAD4 | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-8878159 | 0.0070154156135 | 1.0 | TEAD2 TEAD4 | Transcriptional regulation by RUNX3 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TEAD2 | TEAD4 | 1.0 | 0.949 | bioplex (TEAD2,TEAD4) bioplex_WMM |
Images
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Complex HuMAP2_01219 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TEAD4 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD2 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |