hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01222

Confidence: Medium High

Genename	Protein Name	Links
HK1	Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I)	UniProt NCBI
HK2	Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase)	UniProt NCBI
HK3	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III)	UniProt NCBI
HKDC1	Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)	UniProt NCBI
NUDT13	Nucleoside diphosphate-linked moiety X motif 13 (Nudix motif 13) (EC 3.-.-.-) (Protein KiSS-16)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:00524	5.80815491512e-13	0.8	HKDC1 HK1 HK3 HK2	Neomycin, kanamycin and gentamicin biosynthesis
GO:0004340	6.09856266088e-10	0.8	HKDC1 HK1 HK3 HK2	glucokinase activity
GO:0004396	6.09856266088e-10	0.8	HKDC1 HK1 HK3 HK2	hexokinase activity
GO:0008865	6.09856266088e-10	0.8	HKDC1 HK1 HK3 HK2	fructokinase activity
GO:0019158	6.09856266088e-10	0.8	HKDC1 HK1 HK3 HK2	mannokinase activity
KEGG:00052	2.03625254407e-09	0.8	HKDC1 HK1 HK3 HK2	Galactose metabolism
KEGG:00500	3.6499658048e-09	0.8	HKDC1 HK1 HK3 HK2	Starch and sucrose metabolism
KEGG:00051	4.74624275714e-09	0.8	HKDC1 HK1 HK3 HK2	Fructose and mannose metabolism
WP:WP500	6.65729208537e-09	0.8	HKDC1 HK1 HK3 HK2	Glycogen Synthesis and Degradation
KEGG:04973	1.05961812794e-08	0.8	HKDC1 HK1 HK3 HK2	Carbohydrate digestion and absorption
KEGG:04930	1.57362126176e-08	0.8	HKDC1 HK1 HK3 HK2	Type II diabetes mellitus
KEGG:00520	1.89143161183e-08	0.8	HKDC1 HK1 HK3 HK2	Amino sugar and nucleotide sugar metabolism
KEGG:00010	6.89786581254e-08	0.8	HKDC1 HK1 HK3 HK2	Glycolysis / Gluconeogenesis
KEGG:05230	8.87400860001e-08	0.8	HKDC1 HK1 HK3 HK2	Central carbon metabolism in cancer
KEGG:04066	4.53176595774e-07	0.8	HKDC1 HK1 HK3 HK2	HIF-1 signaling pathway
GO:0019200	7.29370383293e-07	0.8	HKDC1 HK1 HK3 HK2	carbohydrate kinase activity
GO:0051156	7.29370383293e-07	0.8	HKDC1 HK1 HK3 HK2	glucose 6-phosphate metabolic process
KEGG:01200	7.70602259018e-07	0.8	HKDC1 HK1 HK3 HK2	Carbon metabolism
KEGG:04910	1.11852153694e-06	0.8	HKDC1 HK1 HK3 HK2	Insulin signaling pathway
GO:0006734	6.37612051417e-06	0.8	HK1 NUDT13 HK3 HK2	NADH metabolic process
WP:WP534	8.87288130353e-06	0.6	HK1 HK3 HK2	Glycolysis and Gluconeogenesis
WP:WP4018	5.48436819898e-05	0.6	HK1 HK3 HK2	Pathways in clear cell renal cell carcinoma
GO:0001678	7.24275910317e-05	0.8	HKDC1 HK1 HK3 HK2	cellular glucose homeostasis
GO:0006002	0.000108905457596	0.6	HK1 HK3 HK2	fructose 6-phosphate metabolic process
REAC:R-HSA-70171	0.000123638575202	0.6	HK1 HK3 HK2	Glycolysis
REAC:R-HSA-70326	0.000238892911782	0.6	HK1 HK3 HK2	Glucose metabolism
GO:0006096	0.000354439891603	0.8	HKDC1 HK1 HK3 HK2	glycolytic process
GO:0006757	0.00037017279064	0.8	HKDC1 HK1 HK3 HK2	ATP generation from ADP
GO:0046031	0.000403202499238	0.8	HKDC1 HK1 HK3 HK2	ADP metabolic process
GO:0009135	0.000438392708191	0.8	HKDC1 HK1 HK3 HK2	purine nucleoside diphosphate metabolic process
GO:0009179	0.000438392708191	0.8	HKDC1 HK1 HK3 HK2	purine ribonucleoside diphosphate metabolic process
GO:0009185	0.000475835425563	0.8	HKDC1 HK1 HK3 HK2	ribonucleoside diphosphate metabolic process
GO:0006165	0.000495430747346	0.8	HKDC1 HK1 HK3 HK2	nucleoside diphosphate phosphorylation
GO:0046939	0.000515624560733	0.8	HKDC1 HK1 HK3 HK2	nucleotide phosphorylation
GO:0009117	0.000592577561532	1.0	HKDC1 HK1 NUDT13 HK3 HK2	nucleotide metabolic process
GO:0009132	0.000625996400903	0.8	HKDC1 HK1 HK3 HK2	nucleoside diphosphate metabolic process
GO:0042593	0.000625996400903	0.8	HKDC1 HK1 HK3 HK2	glucose homeostasis
GO:0006753	0.000631860315553	1.0	HKDC1 HK1 NUDT13 HK3 HK2	nucleoside phosphate metabolic process
GO:0033500	0.000650038064497	0.8	HKDC1 HK1 HK3 HK2	carbohydrate homeostasis
GO:0006090	0.00117444761379	0.8	HKDC1 HK1 HK3 HK2	pyruvate metabolic process
GO:0055086	0.00142134427834	1.0	HKDC1 HK1 NUDT13 HK3 HK2	nucleobase-containing small molecule metabolic process
GO:0061620	0.00265002518516	0.6	HK1 HK3 HK2	glycolytic process through glucose-6-phosphate
GO:0006735	0.00265002518516	0.6	HK1 HK3 HK2	NADH regeneration
GO:0061615	0.00265002518516	0.6	HK1 HK3 HK2	glycolytic process through fructose-6-phosphate
GO:0061621	0.00265002518516	0.6	HK1 HK3 HK2	canonical glycolysis
GO:0061718	0.00265002518516	0.6	HK1 HK3 HK2	glucose catabolic process to pyruvate
GO:0016052	0.00272639051964	0.8	HKDC1 HK1 HK3 HK2	carbohydrate catabolic process
GO:0006007	0.00367721278555	0.6	HK1 HK3 HK2	glucose catabolic process
REAC:R-HSA-71387	0.00784859202005	0.6	HK1 HK3 HK2	Metabolism of carbohydrates
GO:0019674	0.00893946499793	0.6	HK1 HK3 HK2	NAD metabolic process
KEGG:01100	0.0121945453342	0.8	HKDC1 HK1 HK3 HK2	Metabolic pathways
GO:0072656	0.0135228859698	0.4	HK1 HK2	maintenance of protein location in mitochondrion
GO:0046034	0.0154362793345	0.8	HKDC1 HK1 HK3 HK2	ATP metabolic process
GO:0019320	0.0156368617465	0.6	HK1 HK3 HK2	hexose catabolic process
GO:0019637	0.0195834221745	1.0	HKDC1 HK1 NUDT13 HK3 HK2	organophosphate metabolic process
GO:0046365	0.0250406933376	0.6	HK1 HK3 HK2	monosaccharide catabolic process
GO:0009150	0.0361255742156	0.8	HKDC1 HK1 HK3 HK2	purine ribonucleotide metabolic process
GO:0009259	0.0407779900821	0.8	HKDC1 HK1 HK3 HK2	ribonucleotide metabolic process
GO:0019693	0.0452771886593	0.8	HKDC1 HK1 HK3 HK2	ribose phosphate metabolic process
CORUM:7418	0.0499494897235	0.2	HK1	HK1-VDAC1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
HK1	HKDC1	1.0	0.949	bioplex (HK1) bioplex_WMM
HK3	HKDC1	0.798	0.764	bioplex (HK3) bioplex_WMM
HK1	HK2	0.711	0.728	bioplex (HK1) bioplex_WMM boldt youn_WMM boldt_WMM
HK1	NUDT13	0.042	0.269	fraction
HK2	HK3	0.019	0.184	bioplex (HK3) bioplex_WMM
HK1	HK3	0.013	0.152	bioplex (HK3) bioplex_WMM
HK2	HKDC1	0.007	0.012	bioplex_WMM WMM_only
HK2	NUDT13	0.0	0.012	fraction

Images

Click to enlarge

Complex HuMAP2_01222 has an average edge precision of 0.384 which is ranked 3483 out of all 6965 complexes.

Related Complexes

Genename	Complexes
HK1	HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918
HK2	HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918
HK3	HuMAP2_01222 HuMAP2_01580 HuMAP2_01636 HuMAP2_02487
HKDC1	HuMAP2_01222 HuMAP2_01580 HuMAP2_01636 HuMAP2_02487
NUDT13	HuMAP2_01222 HuMAP2_01636 HuMAP2_02487

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_01222