hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01225
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-174430 | 2.51774270163e-08 | 1.0 | POLE POLA2 POLA1 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-68952 | 2.51774270163e-08 | 1.0 | POLE POLA2 POLA1 | DNA replication initiation |
| CORUM:1108 | 1.02537101962e-07 | 1.0 | POLE POLA2 POLA1 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 1.53242262272e-07 | 1.0 | POLE POLA2 POLA1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.53242262272e-07 | 1.0 | POLE POLA2 POLA1 | DNA synthesome complex (17 subunits) |
| KEGG:03030 | 2.14716765829e-07 | 1.0 | POLE POLA2 POLA1 | DNA replication |
| WP:WP466 | 7.39430675706e-07 | 1.0 | POLE POLA2 POLA1 | DNA Replication |
| REAC:R-HSA-174417 | 9.09984147875e-07 | 1.0 | POLE POLA2 POLA1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 1.82536345868e-06 | 1.0 | POLE POLA2 POLA1 | Extension of Telomeres |
| REAC:R-HSA-68962 | 2.45300074645e-06 | 1.0 | POLE POLA2 POLA1 | Activation of the pre-replicative complex |
| WP:WP4022 | 5.09350508747e-06 | 1.0 | POLE POLA2 POLA1 | Pyrimidine metabolism |
| CORUM:1100 | 2.01342304124e-05 | 0.666666666667 | POLA2 POLA1 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-157579 | 3.8359608447e-05 | 1.0 | POLE POLA2 POLA1 | Telomere Maintenance |
| REAC:R-HSA-69002 | 4.44066869e-05 | 1.0 | POLE POLA2 POLA1 | DNA Replication Pre-Initiation |
| REAC:R-HSA-73886 | 9.17879069632e-05 | 1.0 | POLE POLA2 POLA1 | Chromosome Maintenance |
| REAC:R-HSA-69239 | 0.000120004609098 | 1.0 | POLE POLA2 POLA1 | Synthesis of DNA |
| CORUM:1003 | 0.000120778339722 | 0.666666666667 | POLA2 POLA1 | RC complex (Replication competent complex) |
| REAC:R-HSA-69306 | 0.000146343794532 | 1.0 | POLE POLA2 POLA1 | DNA Replication |
| CORUM:1107 | 0.000150966163965 | 0.666666666667 | POLA2 POLA1 | DNA synthesome core complex |
| REAC:R-HSA-69206 | 0.000160847790881 | 1.0 | POLE POLA2 POLA1 | G1/S Transition |
| REAC:R-HSA-453279 | 0.000233190181847 | 1.0 | POLE POLA2 POLA1 | Mitotic G1-G1/S phases |
| CORUM:1098 | 0.000261639528628 | 0.666666666667 | POLA2 POLA1 | DNA synthesome complex (13 subunits) |
| CORUM:1005 | 0.000261639528628 | 0.666666666667 | POLE POLA1 | RC complex during G2/M-phase of cell cycle |
| CORUM:1004 | 0.000261639528628 | 0.666666666667 | POLE POLA1 | RC complex during S-phase of cell cycle |
| GO:0032201 | 0.000265644334868 | 1.0 | POLE POLA2 POLA1 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-69242 | 0.000295546575822 | 1.0 | POLE POLA2 POLA1 | S Phase |
| GO:0006270 | 0.000368723418654 | 1.0 | POLE POLA2 POLA1 | DNA replication initiation |
| REAC:R-HSA-113501 | 0.000521983812065 | 0.666666666667 | POLA2 POLA1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69109 | 0.00060895383853 | 0.666666666667 | POLA2 POLA1 | Leading Strand Synthesis |
| REAC:R-HSA-69166 | 0.00060895383853 | 0.666666666667 | POLA2 POLA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-174411 | 0.00060895383853 | 0.666666666667 | POLA2 POLA1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69091 | 0.00060895383853 | 0.666666666667 | POLA2 POLA1 | Polymerase switching |
| REAC:R-HSA-69183 | 0.000702607572674 | 0.666666666667 | POLA2 POLA1 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 0.00127110038679 | 0.666666666667 | POLA2 POLA1 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 0.00154525199441 | 0.666666666667 | POLA2 POLA1 | E2F mediated regulation of DNA replication |
| WP:WP45 | 0.00186819955626 | 0.666666666667 | POLE POLA2 | G1 to S cell cycle control |
| GO:0033260 | 0.00200709053011 | 1.0 | POLE POLA2 POLA1 | nuclear DNA replication |
| GO:0044786 | 0.00251749092736 | 1.0 | POLE POLA2 POLA1 | cell cycle DNA replication |
| REAC:R-HSA-69190 | 0.0033164570092 | 0.666666666667 | POLA2 POLA1 | DNA strand elongation |
| WP:WP2446 | 0.00357470816736 | 0.666666666667 | POLE POLA1 | Retinoblastoma Gene in Cancer |
| GO:0006272 | 0.00405722906526 | 0.666666666667 | POLE POLA1 | leading strand elongation |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | POLE POLA2 POLA1 | Cell Cycle, Mitotic |
| GO:0005658 | 0.0135228859698 | 0.666666666667 | POLA2 POLA1 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | POLE POLA2 POLA1 | Cell Cycle |
| GO:0006261 | 0.0302766427817 | 1.0 | POLE POLA2 POLA1 | DNA-dependent DNA replication |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLA2 | POLA1 | 0.902 | 0.826 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| POLE | POLA1 | 0.579 | 0.662 | bioplex_WMM youn_WMM fraction |
| POLE | POLA2 | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01225 has an average edge precision of 0.498 which is ranked 2506 out of all 6965 complexes.
Related Complexes