hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01228
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRDX1 | Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) | UniProt NCBI |
| PRDX2 | Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) | UniProt NCBI |
| PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.15) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008379 | 9.08185760231e-07 | 1.0 | PRDX2 PRDX1 PRDX3 | thioredoxin peroxidase activity |
| GO:0051920 | 9.08185760231e-07 | 1.0 | PRDX2 PRDX1 PRDX3 | peroxiredoxin activity |
| REAC:R-HSA-3299685 | 1.64282711281e-06 | 1.0 | PRDX2 PRDX1 PRDX3 | Detoxification of Reactive Oxygen Species |
| WP:WP15 | 3.22798847941e-06 | 1.0 | PRDX2 PRDX1 PRDX3 | Selenium Micronutrient Network |
| GO:0042744 | 0.000160839698137 | 1.0 | PRDX2 PRDX1 PRDX3 | hydrogen peroxide catabolic process |
| GO:0045454 | 0.000331851076788 | 1.0 | PRDX2 PRDX1 PRDX3 | cell redox homeostasis |
| GO:0042743 | 0.0007056603357 | 1.0 | PRDX2 PRDX1 PRDX3 | hydrogen peroxide metabolic process |
| GO:0017001 | 0.000968126020406 | 1.0 | PRDX2 PRDX1 PRDX3 | antibiotic catabolic process |
| GO:0004601 | 0.0011207920467 | 1.0 | PRDX2 PRDX1 PRDX3 | peroxidase activity |
| GO:0051187 | 0.00120280122085 | 1.0 | PRDX2 PRDX1 PRDX3 | cofactor catabolic process |
| REAC:R-HSA-8862803 | 0.00140483748394 | 0.666666666667 | PRDX2 PRDX1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00140483748394 | 0.666666666667 | PRDX2 PRDX1 | Neurodegenerative Diseases |
| GO:0016684 | 0.00147262321021 | 1.0 | PRDX2 PRDX1 PRDX3 | oxidoreductase activity, acting on peroxide as acceptor |
| GO:0016209 | 0.00360649647245 | 1.0 | PRDX2 PRDX1 PRDX3 | antioxidant activity |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | PRDX2 PRDX1 PRDX3 | Cellular responses to stress |
| GO:0016999 | 0.00865355719779 | 1.0 | PRDX2 PRDX1 PRDX3 | antibiotic metabolic process |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | PRDX2 PRDX1 PRDX3 | Cellular responses to external stimuli |
| GO:0034614 | 0.011404996777 | 1.0 | PRDX2 PRDX1 PRDX3 | cellular response to reactive oxygen species |
| GO:0042737 | 0.0180261250619 | 1.0 | PRDX2 PRDX1 PRDX3 | drug catabolic process |
| REAC:R-HSA-5628897 | 0.0210835773835 | 0.666666666667 | PRDX2 PRDX1 | TP53 Regulates Metabolic Genes |
| GO:0000302 | 0.022423560513 | 1.0 | PRDX2 PRDX1 PRDX3 | response to reactive oxygen species |
| CORUM:3151 | 0.0249904952816 | 0.333333333333 | PRDX1 | Sulphiredoxin-peroxiredoxin complex |
| CORUM:6675 | 0.0499776345577 | 0.333333333333 | PRDX1 | PI4K2A-PRDX1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRDX2 | PRDX3 | 0.998 | 0.945 | hein_WMM bioplex (PRDX3) bioplex_WMM boldt (PRDX2) youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PRDX2 | PRDX1 | 0.993 | 0.918 | hein_WMM bioplex_WMM boldt (PRDX2) hein (PRDX1) Malo fraction boldt_WMM treiber_WMM |
| PRDX3 | PRDX1 | 0.917 | 0.84 | hein_WMM bioplex (PRDX3) bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01228 has an average edge precision of 0.901 which is ranked 558 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRDX1 | HuMAP2_01228 HuMAP2_03283 HuMAP2_05526 HuMAP2_05584 HuMAP2_06137 |
| PRDX2 | HuMAP2_01228 HuMAP2_03714 HuMAP2_03724 HuMAP2_05584 HuMAP2_06137 |
| PRDX3 | HuMAP2_01228 HuMAP2_05584 HuMAP2_06137 HuMAP2_06810 |