hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01231
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TESPA1 | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | UniProt NCBI |
| BOK | Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9) | UniProt NCBI |
| ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | UniProt NCBI |
| ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | UniProt NCBI |
| ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5607763 | 2.28267971382e-07 | 0.6 | ITPR2 ITPR1 ITPR3 | CLEC7A (Dectin-1) induces NFAT activation |
| GO:0005220 | 9.08185760231e-07 | 0.6 | ITPR2 ITPR1 ITPR3 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| REAC:R-HSA-139853 | 9.88662921473e-07 | 0.6 | ITPR2 ITPR1 ITPR3 | Elevation of cytosolic Ca2+ levels |
| REAC:R-HSA-5218921 | 1.5207132982e-06 | 0.6 | ITPR2 ITPR1 ITPR3 | VEGFR2 mediated cell proliferation |
| REAC:R-HSA-2029485 | 3.60987410111e-06 | 0.6 | ITPR2 ITPR1 ITPR3 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-2871809 | 4.80586315819e-06 | 0.6 | ITPR2 ITPR1 ITPR3 | FCERI mediated Ca+2 mobilization |
| REAC:R-HSA-983695 | 5.49186125546e-06 | 0.6 | ITPR2 ITPR1 ITPR3 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| REAC:R-HSA-114508 | 6.24012216224e-06 | 0.6 | ITPR2 ITPR1 ITPR3 | Effects of PIP2 hydrolysis |
| REAC:R-HSA-418360 | 6.24012216224e-06 | 0.6 | ITPR2 ITPR1 ITPR3 | Platelet calcium homeostasis |
| REAC:R-HSA-381676 | 1.77393158174e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| KEGG:04924 | 2.01601392523e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Renin secretion |
| KEGG:04730 | 2.01601392523e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Long-term depression |
| KEGG:04929 | 2.13438745038e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | GnRH secretion |
| REAC:R-HSA-1489509 | 2.47599987196e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | DAG and IP3 signaling |
| KEGG:04927 | 2.51706417018e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Cortisol synthesis and secretion |
| KEGG:04971 | 3.09475559386e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Gastric acid secretion |
| KEGG:04720 | 3.25178756029e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Long-term potentiation |
| REAC:R-HSA-5578775 | 3.84212387398e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Ion homeostasis |
| KEGG:04918 | 4.30639421271e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Thyroid hormone synthesis |
| WP:WP2059 | 5.48436819898e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Alzheimers Disease |
| KEGG:04970 | 5.56685456996e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Salivary secretion |
| REAC:R-HSA-112043 | 5.63522070511e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | PLC beta mediated events |
| REAC:R-HSA-112040 | 5.97963045475e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | G-protein mediated events |
| REAC:R-HSA-4086398 | 6.33776832781e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Ca2+ pathway |
| KEGG:04912 | 7.32179527008e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | GnRH signaling pathway |
| KEGG:04750 | 7.32179527008e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Inflammatory mediator regulation of TRP channels |
| KEGG:04972 | 7.32179527008e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Pancreatic secretion |
| GO:0031095 | 7.62415024416e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | platelet dense tubular network membrane |
| KEGG:04540 | 8.17438290338e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Gap junction |
| KEGG:04625 | 9.41040777628e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | C-type lectin receptor signaling pathway |
| KEGG:04925 | 9.41040777628e-05 | 0.6 | ITPR2 ITPR1 ITPR3 | Aldosterone synthesis and secretion |
| KEGG:04070 | 0.00010764753353 | 0.6 | ITPR2 ITPR1 ITPR3 | Phosphatidylinositol signaling system |
| GO:0070679 | 0.000108905457596 | 0.6 | ITPR2 ITPR1 ITPR3 | inositol 1,4,5 trisphosphate binding |
| KEGG:04726 | 0.000118613727961 | 0.6 | ITPR2 ITPR1 ITPR3 | Serotonergic synapse |
| KEGG:04725 | 0.000122427590077 | 0.6 | ITPR2 ITPR1 ITPR3 | Cholinergic synapse |
| KEGG:04922 | 0.000122427590077 | 0.6 | ITPR2 ITPR1 ITPR3 | Glucagon signaling pathway |
| KEGG:04928 | 0.000126322071771 | 0.6 | ITPR2 ITPR1 ITPR3 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.000134356221711 | 0.6 | ITPR2 ITPR1 ITPR3 | Vascular smooth muscle contraction |
| KEGG:04724 | 0.000138497553003 | 0.6 | ITPR2 ITPR1 ITPR3 | Glutamatergic synapse |
| REAC:R-HSA-422356 | 0.000141520021869 | 0.6 | ITPR2 ITPR1 ITPR3 | Regulation of insulin secretion |
| GO:0031094 | 0.000149729915117 | 0.6 | ITPR2 ITPR1 ITPR3 | platelet dense tubular network |
| KEGG:04114 | 0.000169883843985 | 0.6 | ITPR2 ITPR1 ITPR3 | Oocyte meiosis |
| WP:WP536 | 0.000186709829938 | 0.6 | ITPR2 ITPR1 ITPR3 | Calcium Regulation in the Cardiac Cell |
| KEGG:04611 | 0.000189775187446 | 0.6 | ITPR2 ITPR1 ITPR3 | Platelet activation |
| REAC:R-HSA-418346 | 0.000197423805207 | 0.6 | ITPR2 ITPR1 ITPR3 | Platelet homeostasis |
| REAC:R-HSA-2029480 | 0.000221673564929 | 0.6 | ITPR2 ITPR1 ITPR3 | Fcgamma receptor (FCGR) dependent phagocytosis |
| WP:WP289 | 0.000243151698272 | 0.6 | ITPR2 ITPR1 ITPR3 | Myometrial Relaxation and Contraction Pathways |
| KEGG:04728 | 0.000246133668344 | 0.6 | ITPR2 ITPR1 ITPR3 | Dopaminergic synapse |
| KEGG:04915 | 0.000252313158511 | 0.6 | ITPR2 ITPR1 ITPR3 | Estrogen signaling pathway |
| KEGG:04371 | 0.000264979384683 | 0.6 | ITPR2 ITPR1 ITPR3 | Apelin signaling pathway |
| KEGG:04210 | 0.000271467766564 | 0.6 | ITPR2 ITPR1 ITPR3 | Apoptosis |
| REAC:R-HSA-111885 | 0.000275953181812 | 0.6 | ITPR2 ITPR1 ITPR3 | Opioid Signalling |
| KEGG:04723 | 0.000319861510109 | 0.6 | ITPR2 ITPR1 ITPR3 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-4420097 | 0.000327410819085 | 0.6 | ITPR2 ITPR1 ITPR3 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-5607764 | 0.000338412904811 | 0.6 | ITPR2 ITPR1 ITPR3 | CLEC7A (Dectin-1) signaling |
| KEGG:04921 | 0.000342240622109 | 0.6 | ITPR2 ITPR1 ITPR3 | Oxytocin signaling pathway |
| KEGG:04934 | 0.000390066928635 | 0.6 | ITPR2 ITPR1 ITPR3 | Cushing syndrome |
| KEGG:04022 | 0.000390066928635 | 0.6 | ITPR2 ITPR1 ITPR3 | cGMP-PKG signaling pathway |
| REAC:R-HSA-163685 | 0.000397120285508 | 0.6 | ITPR2 ITPR1 ITPR3 | Integration of energy metabolism |
| REAC:R-HSA-194138 | 0.000422377343701 | 0.6 | ITPR2 ITPR1 ITPR3 | Signaling by VEGF |
| KEGG:04218 | 0.000424294655338 | 0.6 | ITPR2 ITPR1 ITPR3 | Cellular senescence |
| REAC:R-HSA-983705 | 0.000448679555289 | 0.6 | ITPR2 ITPR1 ITPR3 | Signaling by the B Cell Receptor (BCR) |
| KEGG:05010 | 0.000508464109821 | 0.6 | ITPR2 ITPR1 ITPR3 | Alzheimer disease |
| KEGG:04621 | 0.000549173586032 | 0.6 | ITPR2 ITPR1 ITPR3 | NOD-like receptor signaling pathway |
| KEGG:04020 | 0.000559677819772 | 0.6 | ITPR2 ITPR1 ITPR3 | Calcium signaling pathway |
| REAC:R-HSA-5576891 | 0.000564757581481 | 0.6 | ITPR2 ITPR1 ITPR3 | Cardiac conduction |
| KEGG:05167 | 0.000625511303776 | 0.6 | ITPR2 ITPR1 ITPR3 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-2454202 | 0.000754665480287 | 0.6 | ITPR2 ITPR1 ITPR3 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-5621481 | 0.000874143100407 | 0.6 | ITPR2 ITPR1 ITPR3 | C-type lectin receptors (CLRs) |
| KEGG:05205 | 0.000925161775741 | 0.6 | ITPR2 ITPR1 ITPR3 | Proteoglycans in cancer |
| REAC:R-HSA-416476 | 0.00102865345201 | 0.6 | ITPR2 ITPR1 ITPR3 | G alpha (q) signalling events |
| GO:0015278 | 0.00103355958129 | 0.6 | ITPR2 ITPR1 ITPR3 | calcium-release channel activity |
| KEGG:05170 | 0.00109699385517 | 0.6 | ITPR2 ITPR1 ITPR3 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-3858494 | 0.00112457746833 | 0.6 | ITPR2 ITPR1 ITPR3 | Beta-catenin independent WNT signaling |
| KEGG:05163 | 0.00114726739179 | 0.6 | ITPR2 ITPR1 ITPR3 | Human cytomegalovirus infection |
| REAC:R-HSA-397014 | 0.00222754987811 | 0.6 | ITPR2 ITPR1 ITPR3 | Muscle contraction |
| GO:0099604 | 0.00235581550516 | 0.6 | ITPR2 ITPR1 ITPR3 | ligand-gated calcium channel activity |
| GO:0005217 | 0.00330982532021 | 0.6 | ITPR2 ITPR1 ITPR3 | intracellular ligand-gated ion channel activity |
| REAC:R-HSA-76002 | 0.00484900153486 | 0.6 | ITPR2 ITPR1 ITPR3 | Platelet activation, signaling and aggregation |
| GO:0016529 | 0.00763446836913 | 0.6 | ITPR2 ITPR1 ITPR3 | sarcoplasmic reticulum |
| REAC:R-HSA-418594 | 0.00775951386318 | 0.6 | ITPR2 ITPR1 ITPR3 | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 0.00793834312405 | 0.6 | ITPR2 ITPR1 ITPR3 | Intracellular signaling by second messengers |
| GO:0016528 | 0.00964423896068 | 0.6 | ITPR2 ITPR1 ITPR3 | sarcoplasm |
| REAC:R-HSA-195721 | 0.0129604262881 | 0.6 | ITPR2 ITPR1 ITPR3 | Signaling by WNT |
| KEGG:04713 | 0.0162467151192 | 0.4 | ITPR1 ITPR3 | Circadian entrainment |
| GO:1903779 | 0.0264291737868 | 0.6 | ITPR2 ITPR1 ITPR3 | regulation of cardiac conduction |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | ITPR2 ITPR1 ITPR3 | Signaling by Receptor Tyrosine Kinases |
| GO:0043178 | 0.0376065209581 | 0.6 | ITPR2 ITPR1 ITPR3 | alcohol binding |
| CORUM:74 | 0.0499494897235 | 0.2 | ITPR3 | HOMER3-IP3R-TRPC1 complex |
| CORUM:553 | 0.0499494897235 | 0.2 | ITPR1 | RHOA-IP3R-TRPC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITPR1 | TESPA1 | 1.0 | 0.949 | bioplex (TESPA1) bioplex_WMM |
| TESPA1 | ITPR3 | 1.0 | 0.949 | bioplex (TESPA1) bioplex_WMM |
| TESPA1 | ITPR2 | 0.999 | 0.949 | bioplex (TESPA1) bioplex_WMM |
| BOK | TESPA1 | 0.971 | 0.883 | bioplex (TESPA1) bioplex_WMM |
| ITPR1 | ITPR2 | 0.014 | 0.139 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ITPR3 | ITPR2 | 0.011 | 0.139 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ITPR1 | ITPR3 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BOK | ITPR1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| BOK | ITPR3 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| BOK | ITPR2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01231 has an average edge precision of 0.445 which is ranked 2911 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TESPA1 | HuMAP2_01231 HuMAP2_06464 |
| BOK | HuMAP2_01231 HuMAP2_06464 |
| ITPR1 | HuMAP2_01231 HuMAP2_06464 |
| ITPR3 | HuMAP2_01231 HuMAP2_06464 |
| ITPR2 | HuMAP2_01231 HuMAP2_06368 HuMAP2_06464 |