hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01243
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FBXO44 | F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) | UniProt NCBI |
| CDK13 | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | UniProt NCBI |
| CDK12 | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | UniProt NCBI |
| SCAF4 | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | UniProt NCBI |
| CCNK | Cyclin-K | UniProt NCBI |
| SDAD1 | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6796648 | 0.000223228442122 | 0.5 | CDK12 CDK13 CCNK | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0070816 | 0.000299339163023 | 0.5 | CDK12 CDK13 CCNK | phosphorylation of RNA polymerase II C-terminal domain |
| GO:0019908 | 0.00039905855691 | 0.5 | CDK12 CDK13 CCNK | nuclear cyclin-dependent protein kinase holoenzyme complex |
| GO:0008353 | 0.00147880241807 | 0.5 | CDK12 CDK13 CCNK | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0004693 | 0.0032070828615 | 0.5 | CDK12 CDK13 CCNK | cyclin-dependent protein serine/threonine kinase activity |
| GO:0097472 | 0.00366468326223 | 0.5 | CDK12 CDK13 CCNK | cyclin-dependent protein kinase activity |
| GO:0032786 | 0.00661098268806 | 0.5 | CDK12 CDK13 CCNK | positive regulation of DNA-templated transcription, elongation |
| GO:0002944 | 0.00676235117068 | 0.333333333333 | CCNK CDK12 | cyclin K-CDK12 complex |
| GO:0002945 | 0.00676235117068 | 0.333333333333 | CDK13 CCNK | cyclin K-CDK13 complex |
| GO:0000307 | 0.0118307664632 | 0.5 | CDK12 CDK13 CCNK | cyclin-dependent protein kinase holoenzyme complex |
| GO:0032784 | 0.0273937790841 | 0.5 | CDK12 CDK13 CCNK | regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-3700989 | 0.0393483138606 | 0.5 | CDK12 CDK13 CCNK | Transcriptional Regulation by TP53 |
| CORUM:1083 | 0.0499726005494 | 0.166666666667 | CCNK | P-TEFb.4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDK12 | CDK13 | 0.997 | 0.934 | bioplex (CDK13) bioplex_WMM youn_WMM |
| CCNK | CDK12 | 0.424 | 0.575 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| CDK12 | SCAF4 | 0.164 | 0.42 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CDK13 | FBXO44 | 0.08 | 0.351 | bioplex (CDK13) bioplex_WMM |
| CDK12 | SDAD1 | 0.034 | 0.261 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CCNK | CDK13 | 0.024 | 0.214 | bioplex (CDK13) bioplex_WMM youn_WMM |
| CDK12 | FBXO44 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| CCNK | FBXO44 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SCAF4 | SDAD1 | 0.008 | 0.012 | youn_WMM gupta_WMM WMM_only |
| CDK13 | SDAD1 | 0.007 | 0.01 | youn_WMM WMM_only |
| CCNK | SDAD1 | 0.007 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SCAF4 | CDK13 | 0.006 | 0.004 | youn_WMM WMM_only |
| CCNK | SCAF4 | 0.006 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_01243 has an average edge precision of 0.223 which is ranked 5812 out of all 6965 complexes.
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