hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01245
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EHMT2 | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | UniProt NCBI |
| EHMT1 | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | UniProt NCBI |
| XAGE3 | X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein) | UniProt NCBI |
| ZNF644 | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | UniProt NCBI |
| XAGE2 | X antigen family member 2 (XAGE-2) (Cancer/testis antigen 12.2) (CT12.2) (G antigen family D member 3) | UniProt NCBI |
| WIZ | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | UniProt NCBI |
| ZNF462 | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:643 | 0.000362009370683 | 0.285714285714 | EHMT1 EHMT2 | CtBP core complex |
| CORUM:1194 | 0.000663238201611 | 0.285714285714 | EHMT1 EHMT2 | E2F-6 complex |
| CORUM:642 | 0.00136514339455 | 0.285714285714 | EHMT1 EHMT2 | CtBP complex |
| WP:WP4288 | 0.00253615815428 | 0.285714285714 | EHMT1 EHMT2 | MTHFR deficiency |
| REAC:R-HSA-6804760 | 0.00539383467143 | 0.285714285714 | EHMT1 EHMT2 | Regulation of TP53 Activity through Methylation |
| REAC:R-HSA-8953750 | 0.0176362111261 | 0.285714285714 | EHMT1 EHMT2 | Transcriptional Regulation by E2F6 |
| KEGG:00310 | 0.01792209342 | 0.285714285714 | EHMT1 EHMT2 | Lysine degradation |
| WP:WP2369 | 0.02129603246 | 0.285714285714 | EHMT1 EHMT2 | Histone Modifications |
| KEGG:04211 | 0.0323714198719 | 0.285714285714 | EHMT1 EHMT2 | Longevity regulating pathway |
| CORUM:862 | 0.0499886427319 | 0.142857142857 | EHMT2 | DNMT1-EHMT2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WIZ | EHMT1 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (WIZ) Malo fraction |
| WIZ | XAGE2 | 0.434 | 0.578 | bioplex (XAGE2) bioplex_WMM |
| XAGE2 | EHMT2 | 0.426 | 0.575 | bioplex (XAGE2) bioplex_WMM |
| ZNF644 | XAGE2 | 0.371 | 0.546 | bioplex (XAGE2) bioplex_WMM |
| WIZ | XAGE3 | 0.287 | 0.489 | bioplex (XAGE3) bioplex_WMM |
| XAGE2 | EHMT1 | 0.243 | 0.468 | bioplex (XAGE2) bioplex_WMM |
| ZNF644 | EHMT2 | 0.222 | 0.466 | hein_WMM bioplex_WMM youn_WMM hein (ZNF644) |
| WIZ | ZNF462 | 0.172 | 0.432 | bioplex (ZNF462) bioplex_WMM |
| ZNF644 | XAGE3 | 0.129 | 0.4 | bioplex (XAGE3) bioplex_WMM |
| XAGE3 | EHMT2 | 0.119 | 0.392 | bioplex (XAGE3) bioplex_WMM |
| EHMT1 | XAGE3 | 0.119 | 0.393 | bioplex (XAGE3) bioplex_WMM |
| ZNF644 | EHMT1 | 0.112 | 0.381 | hein_WMM bioplex_WMM youn_WMM hein (ZNF644) |
| WIZ | EHMT2 | 0.094 | 0.358 | hein_WMM bioplex_WMM youn_WMM hein (WIZ) |
| ZNF462 | EHMT2 | 0.086 | 0.352 | bioplex (ZNF462) bioplex_WMM |
| EHMT1 | ZNF462 | 0.077 | 0.353 | bioplex (ZNF462) bioplex_WMM |
| ZNF644 | WIZ | 0.049 | 0.295 | hein_WMM bioplex_WMM youn_WMM hein (WIZ,ZNF644) |
| EHMT1 | EHMT2 | 0.028 | 0.233 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ZNF644 | ZNF462 | 0.01 | 0.1 | bioplex (ZNF462) bioplex_WMM |
Images
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Complex HuMAP2_01245 has an average edge precision of 0.431 which is ranked 3015 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EHMT2 | HuMAP2_00144 HuMAP2_01245 |
| EHMT1 | HuMAP2_00144 HuMAP2_01245 HuMAP2_04829 |
| XAGE3 | HuMAP2_00144 HuMAP2_01245 HuMAP2_03328 |
| ZNF644 | HuMAP2_00144 HuMAP2_01245 |
| XAGE2 | HuMAP2_00144 HuMAP2_01245 |
| WIZ | HuMAP2_00144 HuMAP2_01245 HuMAP2_04829 |
| ZNF462 | HuMAP2_00144 HuMAP2_01245 HuMAP2_03168 |