hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01252
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | UniProt NCBI |
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | UniProt NCBI |
| SSMEM1 | Serine-rich single-pass membrane protein 1 | UniProt NCBI |
| ARHGAP5 | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | UniProt NCBI |
| MARS2 | Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-201451 | 2.52095754391e-08 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | Signaling by BMP |
| KEGG:04350 | 1.26150693817e-06 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | TGF-beta signaling pathway |
| REAC:R-HSA-9006936 | 6.87739478972e-06 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | Signaling by TGF-beta family members |
| WP:WP1425 | 0.000452410410067 | 0.285714285714 | SMAD1 SMURF1 | Bone Morphogenic Protein (BMP) Signalling and Regulation |
| WP:WP3876 | 0.000552822266572 | 0.285714285714 | SMAD1 SMAD5 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| WP:WP3927 | 0.00136514339455 | 0.285714285714 | SMAD1 SMAD5 | BMP Signaling Pathway in Eyelid Development |
| WP:WP4331 | 0.00190590477553 | 0.285714285714 | SMAD1 SMAD5 | Neovascularisation processes |
| WP:WP2895 | 0.00190590477553 | 0.285714285714 | SMAD1 SMAD5 | Differentiation of white and brown adipocyte |
| GO:0030509 | 0.00235209893628 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | BMP signaling pathway |
| GO:0071772 | 0.0027945908108 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | response to BMP |
| GO:0071773 | 0.0027945908108 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | cellular response to BMP stimulus |
| REAC:R-HSA-2173788 | 0.00662104130949 | 0.285714285714 | SMURF2 SMURF1 | Downregulation of TGF-beta receptor signaling |
| WP:WP4249 | 0.00702347294811 | 0.285714285714 | SMURF2 SMURF1 | Hedgehog Signaling Pathway |
| GO:0007179 | 0.00892801112716 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | transforming growth factor beta receptor signaling pathway |
| KEGG:04340 | 0.0093000092131 | 0.285714285714 | SMURF2 SMURF1 | Hedgehog signaling pathway |
| WP:WP560 | 0.00943851998861 | 0.285714285714 | SMAD1 SMAD5 | TGF-beta Receptor Signaling |
| REAC:R-HSA-2173789 | 0.0110517363252 | 0.285714285714 | SMURF2 SMURF1 | TGF-beta receptor signaling activates SMADs |
| GO:0071560 | 0.0182937084766 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | cellular response to transforming growth factor beta stimulus |
| GO:0071559 | 0.0208141612097 | 0.571428571429 | SMAD1 SMURF1 SMAD5 SMURF2 | response to transforming growth factor beta |
| CORUM:2992 | 0.0249993571594 | 0.142857142857 | SMURF2 | Ubiquitin E3 ligase (SMAD7, SMURF2) |
| CORUM:2996 | 0.0249993571594 | 0.142857142857 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| REAC:R-HSA-8941858 | 0.0431362871916 | 0.285714285714 | SMURF2 SMURF1 | Regulation of RUNX3 expression and activity |
| WP:WP3931 | 0.0468514080623 | 0.285714285714 | SMAD1 SMAD5 | ESC Pluripotency Pathways |
| CORUM:2642 | 0.0499886427319 | 0.142857142857 | SMAD1 | SMAD1-P300 complex |
| CORUM:2958 | 0.0499886427319 | 0.142857142857 | SMAD1 | SMAD1-CBP complex |
| CORUM:1783 | 0.0499886427319 | 0.142857142857 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMURF1 | SMURF2 | 1.0 | 0.949 | bioplex (SMURF2) bioplex_WMM |
| SMURF2 | SMAD5 | 0.315 | 0.509 | bioplex (SMURF2) bioplex_WMM |
| SMAD1 | SMURF2 | 0.118 | 0.391 | bioplex (SMURF2) bioplex_WMM |
| SMURF2 | MARS2 | 0.084 | 0.347 | bioplex (SMURF2) bioplex_WMM |
| ARHGAP5 | SMURF2 | 0.031 | 0.241 | bioplex (SMURF2) bioplex_WMM |
| SMAD5 | SSMEM1 | 0.021 | 0.188 | bioplex (SSMEM1) bioplex_WMM |
| SMAD1 | SMURF1 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| ARHGAP5 | SMURF1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| SMURF1 | SMAD5 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SMAD1 | ARHGAP5 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SMAD1 | SMAD5 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ARHGAP5 | SMAD5 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| SMURF1 | MARS2 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| SMAD1 | MARS2 | 0.008 | 0.01 | bioplex_WMM WMM_only |
| ARHGAP5 | MARS2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| SMAD5 | MARS2 | 0.007 | 0.016 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01252 has an average edge precision of 0.195 which is ranked 6241 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD1 | HuMAP2_00001 HuMAP2_01252 HuMAP2_02037 HuMAP2_02752 HuMAP2_02905 HuMAP2_04429 |
| SMAD5 | HuMAP2_01252 HuMAP2_01560 HuMAP2_02752 HuMAP2_04429 |
| SSMEM1 | HuMAP2_01252 HuMAP2_01560 HuMAP2_02752 |
| ARHGAP5 | HuMAP2_00074 HuMAP2_01252 HuMAP2_03419 HuMAP2_04299 |
| SMURF1 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_03627 HuMAP2_04429 |
| SMURF2 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |
| MARS2 | HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |