hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01254
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HADHA | Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | UniProt NCBI |
| HADHB | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7262 | 1.67592346237e-06 | 1.0 | HADHA HADHB | 3-Hydroxyacyl CoA dehydrogenase |
| HP:0025145 | 3.33943267688e-06 | 1.0 | HADHA HADHB | Rigors |
| REAC:R-HSA-77305 | 5.02777038712e-06 | 1.0 | HADHA HADHB | Beta oxidation of palmitoyl-CoA to myristoyl-CoA |
| REAC:R-HSA-77285 | 5.02777038712e-06 | 1.0 | HADHA HADHB | Beta oxidation of myristoyl-CoA to lauroyl-CoA |
| HP:0008138 | 1.00182980306e-05 | 1.0 | HADHA HADHB | Equinus calcaneus |
| HP:0025144 | 1.00182980306e-05 | 1.0 | HADHA HADHB | Shivering |
| REAC:R-HSA-77348 | 1.67592346237e-05 | 1.0 | HADHA HADHB | Beta oxidation of octanoyl-CoA to hexanoyl-CoA |
| REAC:R-HSA-77310 | 1.67592346237e-05 | 1.0 | HADHA HADHB | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA |
| REAC:R-HSA-77350 | 1.67592346237e-05 | 1.0 | HADHA HADHB | Beta oxidation of hexanoyl-CoA to butanoyl-CoA |
| HP:0006555 | 2.00365960613e-05 | 1.0 | HADHA HADHB | Diffuse hepatic steatosis |
| WP:WP3871 | 2.45903678934e-05 | 1.0 | HADHA HADHB | Valproic acid pathway |
| REAC:R-HSA-77288 | 2.51388519356e-05 | 1.0 | HADHA HADHB | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids |
| REAC:R-HSA-77346 | 2.51388519356e-05 | 1.0 | HADHA HADHB | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
| REAC:R-HSA-1482798 | 2.51388519356e-05 | 1.0 | HADHA HADHB | Acyl chain remodeling of CL |
| KEGG:00062 | 3.69120786663e-05 | 1.0 | HADHA HADHB | Fatty acid elongation |
| HP:0008110 | 5.00914901532e-05 | 1.0 | HADHA HADHB | Equinovarus deformity |
| HP:0007067 | 5.00914901532e-05 | 1.0 | HADHA HADHB | Distal peripheral sensory neuropathy |
| HP:0003756 | 5.00914901532e-05 | 1.0 | HADHA HADHB | Skeletal myopathy |
| HP:0011808 | 5.00914901532e-05 | 1.0 | HADHA HADHB | Decreased patellar reflex |
| REAC:R-HSA-77286 | 6.03332446455e-05 | 1.0 | HADHA HADHB | mitochondrial fatty acid beta-oxidation of saturated fatty acids |
| HP:0009063 | 0.000120219576368 | 1.0 | HADHA HADHB | Progressive distal muscle weakness |
| HP:0025143 | 0.000120219576368 | 1.0 | HADHA HADHB | Chills |
| KEGG:00071 | 0.000125617785501 | 1.0 | HADHA HADHB | Fatty acid degradation |
| KEGG:00280 | 0.000157715245211 | 1.0 | HADHA HADHB | Valine, leucine and isoleucine degradation |
| KEGG:01212 | 0.000201046815819 | 1.0 | HADHA HADHB | Fatty acid metabolism |
| WP:WP143 | 0.000209018127094 | 1.0 | HADHA HADHB | Fatty Acid Beta Oxidation |
| HP:0100626 | 0.000260475748797 | 1.0 | HADHA HADHB | Chronic hepatic failure |
| HP:0001985 | 0.000303888373596 | 1.0 | HADHA HADHB | Hypoketotic hypoglycemia |
| HP:0002476 | 0.000400731921226 | 1.0 | HADHA HADHB | Primitive reflex |
| GO:0016509 | 0.000450823411379 | 1.0 | HADHA HADHB | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
| HP:0008364 | 0.000510933199563 | 1.0 | HADHA HADHB | Abnormality of the calcaneus |
| HP:0002913 | 0.000771408948359 | 1.0 | HADHA HADHB | Myoglobinuria |
| REAC:R-HSA-77289 | 0.000884887588134 | 1.0 | HADHA HADHB | Mitochondrial Fatty Acid Beta-Oxidation |
| HP:0002600 | 0.000921683418819 | 1.0 | HADHA HADHB | Hyporeflexia of lower limbs |
| HP:0005180 | 0.00100182980306 | 1.0 | HADHA HADHB | Tricuspid regurgitation |
| HP:0031651 | 0.00108531561999 | 1.0 | HADHA HADHB | Abnormal tricuspid valve physiology |
| HP:0003201 | 0.00117214086958 | 1.0 | HADHA HADHB | Rhabdomyolysis |
| TF:M06646 | 0.00135247023414 | 1.0 | HADHA HADHB | Factor: znf607; motif: NGGATCAAGAAA |
| TF:M06646_0 | 0.00135247023414 | 1.0 | HADHA HADHB | Factor: znf607; motif: NGGATCAAGAAA; match class: 0 |
| HP:0000829 | 0.00165635860773 | 1.0 | HADHA HADHB | Hypoparathyroidism |
| HP:0003551 | 0.00287525153479 | 1.0 | HADHA HADHB | Difficulty climbing stairs |
| WP:WP706 | 0.0030283410642 | 1.0 | HADHA HADHB | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| HP:0040083 | 0.00315910331233 | 1.0 | HADHA HADHB | Toe walking |
| HP:0001987 | 0.00345631282057 | 1.0 | HADHA HADHB | Hyperammonemia |
| GO:0035965 | 0.00450823411379 | 1.0 | HADHA HADHB | cardiolipin acyl-chain remodeling |
| HP:0002901 | 0.00460173822874 | 1.0 | HADHA HADHB | Hypocalcemia |
| HP:0011767 | 0.00477872816061 | 1.0 | HADHA HADHB | Abnormality of the parathyroid physiology |
| HP:0007141 | 0.0053297345523 | 1.0 | HADHA HADHB | Sensorimotor neuropathy |
| HP:0002033 | 0.00591079583808 | 1.0 | HADHA HADHB | Poor suck |
| HP:0001789 | 0.00611116179869 | 1.0 | HADHA HADHB | Hydrops fetalis |
| HP:0000828 | 0.00631486719198 | 1.0 | HADHA HADHB | Abnormality of the parathyroid gland |
| HP:0003546 | 0.00652191201795 | 1.0 | HADHA HADHB | Exercise intolerance |
| HP:0001712 | 0.00673229627659 | 1.0 | HADHA HADHB | Left ventricular hypertrophy |
| GO:0003988 | 0.00676235117068 | 1.0 | HADHA HADHB | acetyl-CoA C-acyltransferase activity |
| HP:0001531 | 0.00716308309191 | 1.0 | HADHA HADHB | Failure to thrive in infancy |
| HP:0001259 | 0.00877602907484 | 1.0 | HADHA HADHB | Coma |
| HP:0001850 | 0.00926692567834 | 1.0 | HADHA HADHB | Abnormality of the tarsal bones |
| GO:0003857 | 0.00946729163895 | 1.0 | HADHA HADHB | 3-hydroxyacyl-CoA dehydrogenase activity |
| TF:M06438 | 0.00946729163895 | 1.0 | HADHA HADHB | Factor: ZNF227; motif: NACKGGAAAACM |
| TF:M06438_0 | 0.00946729163895 | 1.0 | HADHA HADHB | Factor: ZNF227; motif: NACKGGAAAACM; match class: 0 |
| REAC:R-HSA-1483206 | 0.00950416195513 | 1.0 | HADHA HADHB | Glycerophospholipid biosynthesis |
| HP:0002359 | 0.0100283163287 | 1.0 | HADHA HADHB | Frequent falls |
| HP:0001711 | 0.0108197618731 | 1.0 | HADHA HADHB | Abnormal left ventricle morphology |
| GO:0004300 | 0.0126230555186 | 1.0 | HADHA HADHB | enoyl-CoA hydratase activity |
| HP:0001653 | 0.0127833482871 | 1.0 | HADHA HADHB | Mitral regurgitation |
| HP:0002157 | 0.0133744278709 | 1.0 | HADHA HADHB | Azotemia |
| HP:0004363 | 0.0136749768118 | 1.0 | HADHA HADHB | Abnormal circulating calcium concentration |
| HP:0007340 | 0.0136749768118 | 1.0 | HADHA HADHB | Lower limb muscle weakness |
| HP:0004364 | 0.0139788651854 | 1.0 | HADHA HADHB | Abnormal circulating nitrogen compound concentration |
| HP:0001714 | 0.0152278130066 | 1.0 | HADHA HADHB | Ventricular hypertrophy |
| HP:0002686 | 0.0155483985436 | 1.0 | HADHA HADHB | Prenatal maternal abnormality |
| HP:0001397 | 0.0158723235132 | 1.0 | HADHA HADHB | Hepatic steatosis |
| HP:0010927 | 0.0165301917506 | 1.0 | HADHA HADHB | Abnormal blood inorganic cation concentration |
| HP:0003324 | 0.0168641350182 | 1.0 | HADHA HADHB | Generalized muscle weakness |
| HP:0031481 | 0.0168641350182 | 1.0 | HADHA HADHB | Abnormal mitral valve physiology |
| HP:0031137 | 0.0189379227106 | 1.0 | HADHA HADHB | Storage in hepatocytes |
| HP:0006561 | 0.0189379227106 | 1.0 | HADHA HADHB | Lipid accumulation in hepatocytes |
| REAC:R-HSA-8978868 | 0.0194876380205 | 1.0 | HADHA HADHB | Fatty acid metabolism |
| HP:0031650 | 0.0218899811969 | 1.0 | HADHA HADHB | Abnormal atrioventricular valve physiology |
| GO:0032048 | 0.0247952876258 | 1.0 | HADHA HADHB | cardiolipin metabolic process |
| HP:0001644 | 0.0254665135939 | 1.0 | HADHA HADHB | Dilated cardiomyopathy |
| HP:0001399 | 0.0262980323304 | 1.0 | HADHA HADHB | Hepatic failure |
| HP:0003394 | 0.0271429087977 | 1.0 | HADHA HADHB | Muscle spasm |
| REAC:R-HSA-1483257 | 0.0282158474125 | 1.0 | HADHA HADHB | Phospholipid metabolism |
| HP:0001518 | 0.0284352692436 | 1.0 | HADHA HADHB | Small for gestational age |
| HP:0003326 | 0.0293135400377 | 1.0 | HADHA HADHB | Myalgia |
| HP:0001254 | 0.0293135400377 | 1.0 | HADHA HADHB | Lethargy |
| GO:0016408 | 0.029754345151 | 1.0 | HADHA HADHB | C-acyltransferase activity |
| HP:0002460 | 0.0315676570945 | 1.0 | HADHA HADHB | Distal muscle weakness |
| HP:0002878 | 0.032028498804 | 1.0 | HADHA HADHB | Respiratory failure |
| HP:0000580 | 0.0329602005208 | 1.0 | HADHA HADHB | Pigmentary retinopathy |
| HP:0002311 | 0.0368205846953 | 1.0 | HADHA HADHB | Incoordination |
| HP:0003128 | 0.0373181601641 | 1.0 | HADHA HADHB | Lactic acidosis |
| HP:0000763 | 0.0383233293999 | 1.0 | HADHA HADHB | Sensory neuropathy |
| HP:0001410 | 0.0451825241182 | 1.0 | HADHA HADHB | Decreased liver function |
| HP:0001635 | 0.0457335305099 | 1.0 | HADHA HADHB | Congestive heart failure |
| HP:0025155 | 0.0468455615913 | 1.0 | HADHA HADHB | Abnormality of hepatobiliary system physiology |
| HP:0001943 | 0.0496840793666 | 1.0 | HADHA HADHB | Hypoglycemia |
| KEGG:00650 | 0.049938686792 | 0.5 | HADHA | Butanoate metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HADHA | HADHB | 1.0 | 0.949 | hein_WMM bioplex (HADHB) bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01254 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HADHA | HuMAP2_01254 HuMAP2_02755 HuMAP2_06681 HuMAP2_06710 |
| HADHB | HuMAP2_01254 HuMAP2_02755 HuMAP2_03276 HuMAP2_06329 HuMAP2_06798 |