hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01263
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SETDB1 | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | UniProt NCBI |
| ATF7IP | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | UniProt NCBI |
| AVP | Vasopressin-neurophysin 2-copeptin (AVP-NPII) [Cleaved into: Arg-vasopressin (Arginine-vasopressin); Neurophysin 2 (Neurophysin-II); Copeptin] | UniProt NCBI |
| ARL14EP | ARL14 effector protein (ARF7 effector protein) | UniProt NCBI |
| KIRREL2 | Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) | UniProt NCBI |
| OXT | Oxytocin-neurophysin 1 (OT-NPI) [Cleaved into: Oxytocin (Ocytocin); Neurophysin 1] | UniProt NCBI |
| MCUB | Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B) | UniProt NCBI |
| VHL | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2749 | 1.16880143691e-05 | 0.25 | ATF7IP SETDB1 | SETDB1-containing HMTase complex |
| CORUM:2238 | 3.50546248845e-05 | 0.25 | ATF7IP SETDB1 | MBD1-MCAF1-SETDB1 complex |
| HPA:023020_13 | 4.29355629885e-05 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Supported,High] |
| HPA:023020_03 | 4.29355629885e-05 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Uncertain,High] |
| HPA:023030_12 | 0.000128772091413 | 0.25 | OXT AVP | hypothalamus; neuronal projections[Supported,Medium] |
| HPA:023030_02 | 0.000128772091413 | 0.25 | OXT AVP | hypothalamus; neuronal projections[Uncertain,Medium] |
| HPA:023030_01 | 0.000128772091413 | 0.25 | OXT AVP | hypothalamus; neuronal projections[Uncertain,Low] |
| HPA:023030_11 | 0.000128772091413 | 0.25 | OXT AVP | hypothalamus; neuronal projections[Supported,Low] |
| REAC:R-HSA-388479 | 0.000134251754877 | 0.25 | OXT AVP | Vasopressin-like receptors |
| HPA:023020_11 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Supported,Low] |
| HPA:023020_12 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Supported,Medium] |
| HPA:023020_01 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Uncertain,Low] |
| HPA:023040_10 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; synapses[Supported,Not detected] |
| HPA:023010_10 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; glial cells[Supported,Not detected] |
| HPA:023030_10 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; neuronal projections[Supported,Not detected] |
| HPA:023020_02 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Uncertain,Medium] |
| HPA:023020_10 | 0.000257475005145 | 0.25 | OXT AVP | hypothalamus; neuronal cells[Supported,Not detected] |
| HPA:023040 | 0.00120025952015 | 0.25 | OXT AVP | hypothalamus; synapses |
| HPA:023030 | 0.00120025952015 | 0.25 | OXT AVP | hypothalamus; neuronal projections |
| HPA:023020 | 0.00120025952015 | 0.25 | OXT AVP | hypothalamus; neuronal cells |
| HPA:023010 | 0.00120025952015 | 0.25 | OXT AVP | hypothalamus; glial cells |
| HPA:023000 | 0.00120025952015 | 0.25 | OXT AVP | hypothalamus |
| CORUM:2759 | 0.0497224828424 | 0.125 | ATF7IP | MBD1-MCAF complex |
| CORUM:6422 | 0.0497224828424 | 0.125 | SETDB1 | SETDB1-DNMT3A complex |
| CORUM:6423 | 0.0497224828424 | 0.125 | SETDB1 | SETDB1-DNMT3B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATF7IP | SETDB1 | 0.995 | 0.924 | hein_WMM bioplex (ATF7IP,SETDB1) bioplex_WMM Guru hein (SETDB1) Malo fraction |
| MCUB | SETDB1 | 0.863 | 0.8 | bioplex (SETDB1) bioplex_WMM |
| SETDB1 | ARL14EP | 0.449 | 0.593 | hein_WMM bioplex_WMM hein (SETDB1) boldt_WMM |
| ATF7IP | VHL | 0.306 | 0.501 | bioplex (VHL) bioplex_WMM |
| SETDB1 | VHL | 0.201 | 0.451 | bioplex (VHL) bioplex_WMM boldt (VHL) boldt_WMM |
| ATF7IP | ARL14EP | 0.141 | 0.405 | hein_WMM bioplex (ATF7IP) bioplex_WMM |
| KIRREL2 | VHL | 0.061 | 0.335 | bioplex (KIRREL2) bioplex_WMM |
| ARL14EP | VHL | 0.045 | 0.287 | bioplex (VHL) bioplex_WMM boldt_WMM |
| AVP | VHL | 0.033 | 0.247 | bioplex (AVP) bioplex_WMM |
| VHL | OXT | 0.031 | 0.241 | bioplex (OXT) bioplex_WMM |
| MCUB | ARL14EP | 0.008 | 0.032 | bioplex_WMM WMM_only |
| ATF7IP | MCUB | 0.008 | 0.012 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01263 has an average edge precision of 0.402 which is ranked 3288 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SETDB1 | HuMAP2_00567 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 |
| ATF7IP | HuMAP2_00567 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 |
| AVP | HuMAP2_00160 HuMAP2_00527 HuMAP2_01263 HuMAP2_04343 |
| ARL14EP | HuMAP2_00567 HuMAP2_01263 HuMAP2_02716 HuMAP2_04251 |
| KIRREL2 | HuMAP2_00567 HuMAP2_01263 HuMAP2_02018 HuMAP2_02716 |
| OXT | HuMAP2_01263 HuMAP2_02716 |
| MCUB | HuMAP2_00567 HuMAP2_00894 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 HuMAP2_04380 |
| VHL | HuMAP2_00567 HuMAP2_01263 HuMAP2_02018 HuMAP2_02716 |