hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01267
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FAM43A | Protein FAM43A | UniProt NCBI |
| PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | UniProt NCBI |
| WNT3 | Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog) | UniProt NCBI |
| WNT3A | Protein Wnt-3a | UniProt NCBI |
| PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | UniProt NCBI |
| PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | UniProt NCBI |
| PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4791275 | 8.17619328953e-11 | 0.714285714286 | PPP2R5E WNT3A PPP2R5C PPP2R5B PPP2R5A | Signaling by WNT in cancer |
| REAC:R-HSA-4641262 | 8.17619328953e-11 | 0.714285714286 | PPP2R5E WNT3A PPP2R5C PPP2R5B PPP2R5A | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-5467348 | 2.85391827984e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839744 | 2.85391827984e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-4839735 | 2.85391827984e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5467340 | 2.85391827984e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-4839748 | 2.85391827984e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | AMER1 mutants destabilize the destruction complex |
| REAC:R-HSA-5467337 | 2.85391827984e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5358749 | 3.89107916309e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | S37 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-4839743 | 3.89107916309e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-5358751 | 3.89107916309e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5339716 | 3.89107916309e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Misspliced GSK3beta mutants stabilize beta-catenin |
| REAC:R-HSA-5358747 | 3.89107916309e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358752 | 3.89107916309e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-432142 | 6.78225759637e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Platelet sensitization by LDL |
| REAC:R-HSA-389513 | 6.78225759637e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | CTLA4 inhibitory signaling |
| REAC:R-HSA-196299 | 6.78225759637e-09 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-201681 | 1.18538614499e-08 | 0.857142857143 | WNT3A PPP2R5B PPP2R5C PPP2R5A WNT3 PPP2R5E | TCF dependent signaling in response to WNT |
| KEGG:05165 | 2.90465117853e-08 | 0.857142857143 | WNT3A PPP2R5B PPP2R5C PPP2R5A WNT3 PPP2R5E | Human papillomavirus infection |
| WP:WP500 | 6.66827477594e-08 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Glycogen Synthesis and Degradation |
| REAC:R-HSA-5673000 | 6.75520268158e-08 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | RAF activation |
| REAC:R-HSA-195721 | 8.91514385088e-08 | 0.857142857143 | WNT3A PPP2R5B PPP2R5C PPP2R5A WNT3 PPP2R5E | Signaling by WNT |
| GO:0072542 | 1.79134017731e-07 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | protein phosphatase activator activity |
| REAC:R-HSA-5675221 | 1.87601191777e-07 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Negative regulation of MAPK pathway |
| GO:0019211 | 4.22108321339e-07 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | phosphatase activator activity |
| REAC:R-HSA-388841 | 8.95849477501e-07 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Costimulation by the CD28 family |
| KEGG:03015 | 2.05895087476e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | mRNA surveillance pathway |
| REAC:R-HSA-6811558 | 2.4429556933e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| WP:WP399 | 3.10033650686e-06 | 0.571428571429 | WNT3A PPP2R5C WNT3 PPP2R5E | Wnt Signaling Pathway and Pluripotency |
| GO:0000159 | 3.30150663924e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | protein phosphatase type 2A complex |
| REAC:R-HSA-199418 | 3.62140081949e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-418346 | 3.81921586265e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Platelet homeostasis |
| WP:WP710 | 4.10973811466e-06 | 0.571428571429 | WNT3A PPP2R5C WNT3 PPP2R5E | DNA Damage Response (only ATM dependent) |
| KEGG:04114 | 4.54258153483e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Oocyte meiosis |
| KEGG:04071 | 4.8954161598e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Sphingolipid signaling pathway |
| REAC:R-HSA-195253 | 4.93220962918e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Degradation of beta-catenin by the destruction complex |
| KEGG:04152 | 5.46259226597e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | AMPK signaling pathway |
| KEGG:04728 | 7.46106182314e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Dopaminergic synapse |
| REAC:R-HSA-141424 | 7.86655162634e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 7.86655162634e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| KEGG:04261 | 9.65640805164e-06 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-69618 | 1.44937216864e-05 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Mitotic Spindle Checkpoint |
| REAC:R-HSA-5663202 | 1.94836234046e-05 | 0.714285714286 | PPP2R5E WNT3A PPP2R5C PPP2R5B PPP2R5A | Diseases of signal transduction |
| REAC:R-HSA-2500257 | 2.30223008303e-05 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 3.48399314081e-05 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | RHO GTPases Activate Formins |
| GO:0031952 | 4.44842942078e-05 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | regulation of protein autophosphorylation |
| GO:0008287 | 6.98341385223e-05 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | protein serine/threonine phosphatase complex |
| GO:1903293 | 6.98341385223e-05 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | phosphatase complex |
| REAC:R-HSA-2467813 | 0.000125424876484 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.0001488509542 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.0001488509542 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000151993265715 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Mitotic Metaphase and Anaphase |
| WP:WP3932 | 0.000152413265395 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-5673001 | 0.000158426073041 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.000175396215465 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.000221637163545 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | FLT3 Signaling |
| WP:WP4172 | 0.000240159876739 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | PI3K-Akt Signaling Pathway |
| GO:0019888 | 0.000248057665948 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | protein phosphatase regulator activity |
| KEGG:04151 | 0.000282169949161 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | PI3K-Akt signaling pathway |
| REAC:R-HSA-1257604 | 0.00028643698831 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.000296731739946 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.000346508302524 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | MAPK family signaling cascades |
| GO:0019208 | 0.000503784351922 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | phosphatase regulator activity |
| REAC:R-HSA-9006925 | 0.000533481886885 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Intracellular signaling by second messengers |
| REAC:R-HSA-69620 | 0.000755017672692 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.00101240038307 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 0.00222625241558 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | M Phase |
| REAC:R-HSA-1643685 | 0.00327633709382 | 0.714285714286 | PPP2R5E WNT3A PPP2R5C PPP2R5B PPP2R5A | Disease |
| REAC:R-HSA-194315 | 0.00374244313656 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Signaling by Rho GTPases |
| REAC:R-HSA-162582 | 0.00544066626924 | 0.857142857143 | WNT3A PPP2R5B PPP2R5C PPP2R5A WNT3 PPP2R5E | Signal Transduction |
| WP:WP4150 | 0.00560981609224 | 0.285714285714 | WNT3A WNT3 | Wnt Signaling in Kidney Disease |
| REAC:R-HSA-449147 | 0.00732463375585 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Signaling by Interleukins |
| REAC:R-HSA-69278 | 0.0076688970217 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Cell Cycle, Mitotic |
| REAC:R-HSA-3238698 | 0.00797320623754 | 0.285714285714 | WNT3A WNT3 | WNT ligand biogenesis and trafficking |
| REAC:R-HSA-109582 | 0.00890318946488 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Hemostasis |
| KEGG:05217 | 0.0150988919917 | 0.285714285714 | WNT3A WNT3 | Basal cell carcinoma |
| REAC:R-HSA-1640170 | 0.0155446721983 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Cell Cycle |
| REAC:R-HSA-1280218 | 0.0187049526139 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Adaptive Immune System |
| REAC:R-HSA-1280215 | 0.0238923711979 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | Cytokine Signaling in Immune system |
| GO:0006470 | 0.0266230678728 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | protein dephosphorylation |
| WP:WP4336 | 0.0297343384587 | 0.285714285714 | WNT3A WNT3 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 0.0369669918209 | 0.285714285714 | WNT3A WNT3 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:04916 | 0.0381112991793 | 0.285714285714 | WNT3A WNT3 | Melanogenesis |
| GO:0046777 | 0.0445064353059 | 0.571428571429 | PPP2R5E PPP2R5A PPP2R5C PPP2R5B | protein autophosphorylation |
| WP:WP3931 | 0.0468514080623 | 0.285714285714 | WNT3A WNT3 | ESC Pluripotency Pathways |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WNT3A | WNT3 | 1.0 | 0.949 | bioplex (WNT3A) bioplex_WMM |
| WNT3A | PPP2R5A | 0.831 | 0.778 | bioplex (WNT3A) bioplex_WMM |
| WNT3A | PPP2R5B | 0.54 | 0.641 | bioplex (WNT3A) bioplex_WMM |
| FAM43A | PPP2R5A | 0.301 | 0.496 | bioplex (FAM43A) bioplex_WMM |
| WNT3A | PPP2R5E | 0.233 | 0.471 | bioplex (WNT3A) bioplex_WMM |
| FAM43A | PPP2R5E | 0.164 | 0.42 | bioplex (FAM43A) bioplex_WMM |
| FAM43A | PPP2R5C | 0.101 | 0.364 | bioplex (FAM43A) bioplex_WMM |
| FAM43A | PPP2R5B | 0.099 | 0.358 | bioplex (FAM43A) bioplex_WMM |
| PPP2R5C | PPP2R5E | 0.095 | 0.358 | hein_WMM bioplex_WMM Guru boldt fraction boldt_WMM |
| PPP2R5A | PPP2R5E | 0.02 | 0.189 | hein_WMM bioplex_WMM WMM_only |
| PPP2R5A | PPP2R5C | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| PPP2R5A | PPP2R5B | 0.011 | 0.147 | bioplex_WMM WMM_only |
| PPP2R5B | WNT3 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| PPP2R5B | PPP2R5E | 0.009 | 0.105 | bioplex_WMM WMM_only |
| PPP2R5A | WNT3 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| PPP2R5B | PPP2R5C | 0.008 | 0.067 | bioplex_WMM WMM_only |
| PPP2R5E | WNT3 | 0.008 | 0.059 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01267 has an average edge precision of 0.338 which is ranked 4145 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FAM43A | HuMAP2_01267 HuMAP2_01788 HuMAP2_06317 |
| PPP2R5C | HuMAP2_01267 HuMAP2_01788 HuMAP2_02007 |
| WNT3 | HuMAP2_01267 HuMAP2_01788 HuMAP2_04233 HuMAP2_05101 HuMAP2_06317 |
| WNT3A | HuMAP2_01267 HuMAP2_01788 HuMAP2_04233 HuMAP2_05101 HuMAP2_06317 |
| PPP2R5A | HuMAP2_01267 HuMAP2_01788 HuMAP2_04233 HuMAP2_05101 HuMAP2_06317 |
| PPP2R5B | HuMAP2_01267 HuMAP2_01788 HuMAP2_05101 HuMAP2_06317 |
| PPP2R5E | HuMAP2_01267 HuMAP2_01788 HuMAP2_02007 HuMAP2_02325 HuMAP2_04458 |