hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01276
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TP53BP2 | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | UniProt NCBI |
| PARD3 | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | UniProt NCBI |
| PRKCI | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | UniProt NCBI |
| FRMD6 | FERM domain-containing protein 6 (Willin) | UniProt NCBI |
| ZNF639 | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | UniProt NCBI |
| PARD6B | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | UniProt NCBI |
| RASSF8 | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:956 | 3.38154272427e-09 | 0.428571428571 | PARD6B PRKCI PARD3 | PAR-3-PAR-6B-PRKCI complex |
| KEGG:04390 | 7.95645929044e-08 | 0.714285714286 | FRMD6 PARD6B PRKCI PARD3 TP53BP2 | Hippo signaling pathway |
| REAC:R-HSA-420029 | 4.82539273521e-06 | 0.428571428571 | PARD6B PRKCI PARD3 | Tight junction interactions |
| CORUM:959 | 3.02079974644e-05 | 0.285714285714 | PARD6B PRKCI | LLGL1-PAR-6B-PRKCI complex |
| CORUM:955 | 3.02079974644e-05 | 0.285714285714 | PARD6B PRKCI | LLGL2-PAR-6B-PRKCI complex |
| CORUM:847 | 3.02079974644e-05 | 0.285714285714 | PRKCI PARD3 | RICH1-PAR3-aPKC polarity complex |
| CORUM:7444 | 6.04024714829e-05 | 0.285714285714 | PRKCI PARD3 | HOOK2-PAR3-Par6alpha-PKCiota complex |
| CORUM:905 | 0.000100648251269 | 0.285714285714 | PRKCI PARD3 | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| REAC:R-HSA-421270 | 0.00013963689386 | 0.428571428571 | PARD6B PRKCI PARD3 | Cell-cell junction organization |
| REAC:R-HSA-446728 | 0.000599332039372 | 0.428571428571 | PARD6B PRKCI PARD3 | Cell junction organization |
| KEGG:04530 | 0.00161119746705 | 0.428571428571 | PARD6B PRKCI PARD3 | Tight junction |
| REAC:R-HSA-1500931 | 0.00184251586032 | 0.428571428571 | PARD6B PRKCI PARD3 | Cell-Cell communication |
| KEGG:04015 | 0.00273015558045 | 0.428571428571 | PARD6B PRKCI PARD3 | Rap1 signaling pathway |
| KEGG:04144 | 0.00645172813212 | 0.428571428571 | PARD6B PRKCI PARD3 | Endocytosis |
| KEGG:05165 | 0.0156896284271 | 0.428571428571 | PARD6B PRKCI PARD3 | Human papillomavirus infection |
| GO:0070830 | 0.0336257766492 | 0.428571428571 | PARD6B PRKCI PARD3 | bicellular tight junction assembly |
| GO:0120192 | 0.0362050681854 | 0.428571428571 | PARD6B PRKCI PARD3 | tight junction assembly |
| GO:0120193 | 0.0417514312642 | 0.428571428571 | PARD6B PRKCI PARD3 | tight junction organization |
| CORUM:5558 | 0.0499886427319 | 0.142857142857 | PARD6B | PAR6-CDC42 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PARD6B | PARD3 | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B) |
| RASSF8 | PARD3 | 1.0 | 0.949 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM hein (RASSF8) gupta_WMM boldt_WMM |
| PRKCI | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B,PRKCI) |
| TP53BP2 | RASSF8 | 1.0 | 0.949 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM hein (RASSF8) gupta_WMM boldt_WMM |
| PARD6B | RASSF8 | 0.76 | 0.75 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B) |
| FRMD6 | RASSF8 | 0.181 | 0.436 | bioplex (FRMD6,RASSF8) bioplex_WMM boldt_WMM |
| PRKCI | PARD3 | 0.157 | 0.415 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRKCI) gupta_WMM boldt_WMM |
| RASSF8 | ZNF639 | 0.081 | 0.35 | bioplex (RASSF8) bioplex_WMM |
| FRMD6 | TP53BP2 | 0.047 | 0.29 | bioplex (FRMD6) bioplex_WMM boldt_WMM |
| PARD6B | TP53BP2 | 0.027 | 0.228 | hein_WMM hein (PARD6B) |
| TP53BP2 | PARD3 | 0.011 | 0.133 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| FRMD6 | PARD3 | 0.008 | 0.085 | bioplex_WMM WMM_only boldt_WMM |
| PARD3 | ZNF639 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| FRMD6 | ZNF639 | 0.008 | 0.069 | bioplex_WMM WMM_only |
| TP53BP2 | ZNF639 | 0.008 | 0.03 | bioplex_WMM WMM_only |
| PRKCI | TP53BP2 | 0.007 | 0.009 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| FRMD6 | PRKCI | 0.007 | 0.005 | bioplex_WMM WMM_only boldt_WMM |
| PRKCI | ZNF639 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| PRKCI | RASSF8 | 0.003 | 0.013 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_01276 has an average edge precision of 0.352 which is ranked 3905 out of all 6965 complexes.
Related Complexes