hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01279
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| INO80 | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | UniProt NCBI |
| ACTR8 | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | UniProt NCBI |
| ACTR5 | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | UniProt NCBI |
| NFRKB | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | UniProt NCBI |
| INO80E | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | UniProt NCBI |
| INO80D | INO80 complex subunit D | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:302 | 7.02836139507e-18 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | INO80 chromatin remodeling complex |
| REAC:R-HSA-5696394 | 2.98805254198e-14 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696399 | 4.39959637066e-12 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5689603 | 1.29023063657e-11 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | UCH proteinases |
| REAC:R-HSA-5696398 | 2.3182559747e-11 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | Nucleotide Excision Repair |
| GO:0031011 | 1.47519544769e-10 | 0.833333333333 | INO80 INO80E ACTR8 NFRKB ACTR5 | Ino80 complex |
| GO:0033202 | 1.47519544769e-10 | 0.833333333333 | INO80 INO80E ACTR8 NFRKB ACTR5 | DNA helicase complex |
| GO:0097346 | 2.60849957036e-09 | 0.833333333333 | INO80 INO80E ACTR8 NFRKB ACTR5 | INO80-type complex |
| REAC:R-HSA-5688426 | 5.03116420316e-09 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | Deubiquitination |
| REAC:R-HSA-73894 | 1.56912906071e-08 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | DNA Repair |
| GO:0016579 | 9.32277453109e-07 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | protein deubiquitination |
| GO:0070603 | 9.67214108277e-07 | 0.833333333333 | INO80 INO80E ACTR8 NFRKB ACTR5 | SWI/SNF superfamily-type complex |
| GO:1904949 | 1.17664441353e-06 | 0.833333333333 | INO80 INO80E ACTR8 NFRKB ACTR5 | ATPase complex |
| GO:0070646 | 1.3678729472e-06 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | protein modification by small protein removal |
| REAC:R-HSA-597592 | 5.91578058515e-05 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | Post-translational protein modification |
| REAC:R-HSA-392499 | 0.000522475750064 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | Metabolism of proteins |
| GO:0070647 | 0.00129013354015 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | protein modification by small protein conjugation or removal |
| CORUM:0000000 | 0.0090785708022 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | CORUM root |
| GO:0006508 | 0.0156078159661 | 1.0 | INO80D INO80E ACTR8 ACTR5 NFRKB INO80 | proteolysis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACTR5 | INO80E | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| NFRKB | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | INO80E | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | INO80E | 0.998 | 0.944 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | ACTR8 | 0.998 | 0.944 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| INO80 | NFRKB | 0.997 | 0.93 | hein_WMM bioplex_WMM Malo fraction |
| ACTR5 | ACTR8 | 0.076 | 0.358 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80D | ACTR5 | 0.074 | 0.356 | hein_WMM bioplex_WMM hein (ACTR5) |
| ACTR8 | INO80E | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| INO80 | ACTR8 | 0.02 | 0.187 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80E | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| INO80D | NFRKB | 0.015 | 0.151 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80 | 0.015 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| INO80D | ACTR8 | 0.015 | 0.143 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01279 has an average edge precision of 0.554 which is ranked 2174 out of all 6965 complexes.
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