hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01283
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CASP1 | Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] | UniProt NCBI |
| CASP12 | Inactive caspase-12 (CASP-12) | UniProt NCBI |
| PI4KB | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05014 | 0.000569740713521 | 0.666666666667 | CASP12 CASP1 | Amyotrophic lateral sclerosis (ALS) |
| WP:WP2447 | 0.000673229988357 | 0.666666666667 | CASP12 CASP1 | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04621 | 0.00551574183542 | 0.666666666667 | CASP12 CASP1 | NOD-like receptor signaling pathway |
| GO:0072557 | 0.00811409485621 | 0.666666666667 | CASP12 CASP1 | IPAF inflammasome complex |
| GO:0097169 | 0.0135228859698 | 0.666666666667 | CASP12 CASP1 | AIM2 inflammasome complex |
| GO:0072559 | 0.0378589948753 | 0.666666666667 | CASP12 CASP1 | NLRP3 inflammasome complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASP12 | CASP1 | 0.566 | 0.654 | bioplex (CASP1) bioplex_WMM |
| CASP1 | PI4KB | 0.5 | 0.621 | bioplex (CASP1) bioplex_WMM |
| CASP12 | PI4KB | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01283 has an average edge precision of 0.452 which is ranked 2861 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CASP1 | HuMAP2_00389 HuMAP2_01283 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |
| CASP12 | HuMAP2_00389 HuMAP2_01283 HuMAP2_03028 HuMAP2_05088 |
| PI4KB | HuMAP2_00389 HuMAP2_01283 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |