hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01285
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KPNA2 | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | UniProt NCBI |
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | UniProt NCBI |
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | UniProt NCBI |
| KPNB1 | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | UniProt NCBI |
| NUP98 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | UniProt NCBI |
| KPNA6 | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | UniProt NCBI |
| NUP153 | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | UniProt NCBI |
| CDCA2 | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0075733 | 2.19301728846e-12 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | intracellular transport of virus |
| GO:0046794 | 3.2732826498e-12 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | transport of virus |
| GO:0008139 | 6.88404783182e-12 | 0.75 | KPNB1 KPNA6 NUP153 NUP98 KPNA1 KPNA2 | nuclear localization sequence binding |
| GO:1902579 | 1.33480579567e-11 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | multi-organism localization |
| GO:0044766 | 1.33480579567e-11 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | multi-organism transport |
| GO:0005643 | 2.97381168338e-11 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | nuclear pore |
| GO:0006606 | 1.83855590913e-10 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | protein import into nucleus |
| GO:0005048 | 3.00431142893e-10 | 0.75 | KPNB1 KPNA6 NUP153 NUP98 KPNA1 KPNA2 | signal sequence binding |
| GO:0051170 | 6.91000797758e-10 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | import into nucleus |
| REAC:R-HSA-168276 | 7.05299066681e-10 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 8.12025961431e-10 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Host Interactions with Influenza Factors |
| GO:0017038 | 2.57450329888e-09 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | protein import |
| REAC:R-HSA-1169408 | 1.55477509364e-08 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | ISG15 antiviral mechanism |
| GO:0034504 | 1.67484893479e-08 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | protein localization to nucleus |
| REAC:R-HSA-1169410 | 2.59027675215e-08 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Antiviral mechanism by IFN-stimulated genes |
| GO:0019058 | 9.05914550983e-08 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | viral life cycle |
| REAC:R-HSA-168271 | 1.23350862584e-07 | 0.5 | NUP153 KPNA1 KPNB1 NUP50 | Transport of Ribonucleoproteins into the Host Nucleus |
| GO:0006913 | 2.22594050537e-07 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | nucleocytoplasmic transport |
| GO:0051169 | 2.40802029183e-07 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | nuclear transport |
| GO:0005635 | 6.80682745504e-07 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | nuclear envelope |
| REAC:R-HSA-168254 | 8.77684058064e-07 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Influenza Infection |
| REAC:R-HSA-913531 | 1.98304618039e-06 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Interferon Signaling |
| GO:0042277 | 6.38964767359e-06 | 0.75 | KPNB1 KPNA6 NUP153 NUP98 KPNA1 KPNA2 | peptide binding |
| GO:0016032 | 6.74344260206e-06 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | viral process |
| GO:0006607 | 8.24534072683e-06 | 0.5 | KPNA1 KPNA6 KPNB1 KPNA2 | NLS-bearing protein import into nucleus |
| CORUM:6142 | 1.16880143691e-05 | 0.25 | KPNB1 KPNA2 | KPNA2-KPNB1 complex |
| GO:0072594 | 1.19602526173e-05 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | establishment of protein localization to organelle |
| GO:0044403 | 1.32616080196e-05 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | symbiotic process |
| GO:0033218 | 1.64486397355e-05 | 0.75 | KPNB1 KPNA6 NUP153 NUP98 KPNA1 KPNA2 | amide binding |
| GO:0044419 | 1.94812476105e-05 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | interspecies interaction between organisms |
| KEGG:05164 | 3.05476150525e-05 | 0.5 | KPNA1 KPNA6 KPNA2 NUP98 | Influenza A |
| KEGG:03013 | 3.4898815394e-05 | 0.5 | NUP153 NUP98 KPNB1 NUP50 | RNA transport |
| REAC:R-HSA-162909 | 5.18533650403e-05 | 0.5 | NUP153 KPNA1 KPNB1 NUP50 | Host Interactions of HIV factors |
| REAC:R-HSA-180746 | 7.27251966908e-05 | 0.375 | NUP50 KPNB1 NUP153 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 7.27251966908e-05 | 0.375 | KPNA1 NUP153 NUP50 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-5663205 | 7.30114744836e-05 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Infectious disease |
| REAC:R-HSA-168255 | 8.50890179071e-05 | 0.5 | NUP153 KPNA1 KPNB1 NUP50 | Influenza Life Cycle |
| REAC:R-HSA-176033 | 9.76573076151e-05 | 0.375 | KPNA1 NUP153 NUP50 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 9.76573076151e-05 | 0.375 | NUP50 KPNB1 NUP153 | Interactions of Rev with host cellular proteins |
| GO:0033365 | 0.000354351683068 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | protein localization to organelle |
| REAC:R-HSA-162906 | 0.000579260147565 | 0.5 | NUP153 KPNA1 KPNB1 NUP50 | HIV Infection |
| GO:0031975 | 0.000579765850849 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | envelope |
| GO:0031967 | 0.000579765850849 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | organelle envelope |
| GO:0006886 | 0.00126161552133 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | intracellular protein transport |
| GO:0019054 | 0.00184612317041 | 0.375 | KPNA1 KPNB1 KPNA2 | modulation by virus of host cellular process |
| REAC:R-HSA-1280215 | 0.001858674793 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Cytokine Signaling in Immune system |
| REAC:R-HSA-140342 | 0.00348118046261 | 0.25 | KPNA1 KPNB1 | Apoptosis induced DNA fragmentation |
| GO:0044068 | 0.00673356194115 | 0.375 | KPNA1 KPNB1 KPNA2 | modulation by symbiont of host cellular process |
| REAC:R-HSA-1643685 | 0.00877565882558 | 0.625 | NUP153 KPNA1 NUP50 KPNB1 KPNA2 | Disease |
| REAC:R-HSA-162587 | 0.00883818351303 | 0.375 | KPNA1 NUP153 NUP50 | HIV Life Cycle |
| GO:0019048 | 0.0116327718591 | 0.375 | KPNA1 KPNB1 KPNA2 | modulation by virus of host morphology or physiology |
| GO:1902594 | 0.0126230555186 | 0.25 | KPNA6 KPNA2 | multi-organism nuclear import |
| GO:0099527 | 0.0126230555186 | 0.25 | KPNA1 KPNA2 | postsynapse to nucleus signaling pathway |
| GO:0075732 | 0.0126230555186 | 0.25 | KPNA6 KPNA2 | viral penetration into host nucleus |
| GO:0075506 | 0.0126230555186 | 0.25 | KPNA6 KPNA2 | entry of viral genome into host nucleus through nuclear pore complex via importin |
| GO:0015031 | 0.015872461676 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | protein transport |
| REAC:R-HSA-5619107 | 0.0168024726075 | 0.25 | NUP50 NUP153 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168274 | 0.0168024726075 | 0.25 | NUP50 NUP153 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-170822 | 0.0168024726075 | 0.25 | NUP50 NUP153 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168333 | 0.0168024726075 | 0.25 | NUP50 NUP153 | NEP/NS2 Interacts with the Cellular Export Machinery |
| GO:0015833 | 0.017521243769 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | peptide transport |
| GO:0042886 | 0.019118228808 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | amide transport |
| REAC:R-HSA-159227 | 0.0193257881708 | 0.25 | NUP50 NUP153 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-4085377 | 0.0206530496387 | 0.25 | NUP50 NUP153 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 0.0206530496387 | 0.25 | NUP50 NUP153 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 0.0206530496387 | 0.25 | NUP50 NUP153 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 0.0220239994975 | 0.25 | NUP50 NUP153 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-3232142 | 0.0248968222949 | 0.25 | NUP50 NUP153 | SUMOylation of ubiquitinylation proteins |
| GO:0046907 | 0.0266810279817 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | intracellular transport |
| GO:0045184 | 0.0269411801123 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | establishment of protein localization |
| GO:0071431 | 0.0275393607475 | 0.375 | NUP98 NUP153 NUP50 | tRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0006409 | 0.0275393607475 | 0.375 | NUP98 NUP153 NUP50 | tRNA export from nucleus |
| REAC:R-HSA-159231 | 0.0295328318157 | 0.25 | NUP50 NUP153 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.0311651665682 | 0.25 | NUP50 NUP153 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| GO:0044003 | 0.0330194726961 | 0.375 | KPNA1 KPNB1 KPNA2 | modification by symbiont of host morphology or physiology |
| GO:0051031 | 0.0330194726961 | 0.375 | NUP98 NUP153 NUP50 | tRNA transport |
| REAC:R-HSA-168325 | 0.0345601208955 | 0.25 | NUP50 NUP153 | Viral Messenger RNA Synthesis |
| GO:0051704 | 0.0356536253492 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | multi-organism process |
| REAC:R-HSA-4570464 | 0.0381285523959 | 0.25 | NUP50 NUP153 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 0.0381285523959 | 0.25 | NUP50 NUP153 | SUMOylation of DNA replication proteins |
| GO:0097064 | 0.039179823435 | 0.375 | NUP98 NUP153 NUP50 | ncRNA export from nucleus |
| GO:0034613 | 0.0398294539613 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | cellular protein localization |
| GO:0070727 | 0.0414994148133 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | cellular macromolecule localization |
| REAC:R-HSA-2980766 | 0.0438058506747 | 0.25 | NUP50 NUP153 | Nuclear Envelope Breakdown |
| GO:0071705 | 0.046040830139 | 0.875 | KPNB1 KPNA6 NUP50 NUP153 NUP98 KPNA1 KPNA2 | nitrogen compound transport |
| CORUM:6143 | 0.0497224828424 | 0.125 | KPNB1 | KPNB1-RAN complex |
| CORUM:7543 | 0.0497224828424 | 0.125 | KPNB1 | KPNB1-SMN-SPN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP50 | NUP153 | 1.0 | 0.949 | hein_WMM bioplex (NUP50) bioplex_WMM Guru boldt youn_WMM hein (NUP153) gupta_WMM fraction boldt_WMM |
| KPNB1 | KPNA2 | 0.988 | 0.901 | hein_WMM bioplex (KPNA2) bioplex_WMM boldt hein (KPNB1) fraction boldt_WMM treiber_WMM |
| KPNB1 | NUP50 | 0.944 | 0.856 | hein_WMM bioplex (NUP50) bioplex_WMM boldt hein (KPNB1) boldt_WMM |
| KPNA1 | NUP50 | 0.894 | 0.82 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KPNA1) gupta_WMM treiber_WMM |
| KPNA2 | NUP153 | 0.661 | 0.698 | hein_WMM bioplex (KPNA2) bioplex_WMM Guru youn_WMM hein (NUP153) gupta_WMM fraction |
| NUP98 | KPNB1 | 0.344 | 0.533 | hein_WMM bioplex_WMM boldt hein (KPNB1,NUP98) fraction boldt_WMM treiber_WMM |
| KPNB1 | NUP153 | 0.206 | 0.453 | hein_WMM bioplex_WMM boldt hein (KPNB1,NUP153) fraction boldt_WMM treiber_WMM |
| NUP50 | CDCA2 | 0.155 | 0.416 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM |
| NUP98 | NUP153 | 0.139 | 0.407 | hein_WMM bioplex_WMM boldt youn_WMM hein (NUP153,NUP98) gupta_WMM boldt_WMM |
| KPNA6 | NUP50 | 0.111 | 0.381 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM |
| NUP153 | CDCA2 | 0.098 | 0.357 | hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM |
| NUP98 | NUP50 | 0.055 | 0.305 | hein_WMM bioplex_WMM boldt youn_WMM hein (NUP98) gupta_WMM boldt_WMM |
| KPNA2 | CDCA2 | 0.054 | 0.298 | hein_WMM bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM |
| KPNA6 | KPNA1 | 0.05 | 0.296 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| KPNA6 | KPNA2 | 0.044 | 0.28 | hein_WMM bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM fraction |
| KPNA2 | NUP50 | 0.037 | 0.265 | hein_WMM bioplex (KPNA2,NUP50) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| KPNB1 | CDCA2 | 0.032 | 0.243 | hein_WMM bioplex_WMM hein (KPNB1) |
| KPNA1 | CDCA2 | 0.008 | 0.086 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KPNA1 | KPNA2 | 0.008 | 0.041 | hein_WMM bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM fraction |
| KPNA6 | CDCA2 | 0.008 | 0.024 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NUP98 | KPNA1 | 0.006 | 0.005 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KPNA6 | NUP98 | 0.005 | 0.01 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NUP98 | KPNA2 | 0.004 | 0.011 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| KPNA6 | NUP153 | 0.003 | 0.014 | hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM |
| NUP98 | CDCA2 | 0.003 | 0.017 | hein_WMM bioplex_WMM youn_WMM hein (NUP98) gupta_WMM |
| KPNA1 | NUP153 | 0.0 | 0.009 | hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM |
| KPNB1 | KPNA1 | 0.0 | 0.013 | hein_WMM bioplex_WMM hein (KPNB1) |
| KPNA6 | KPNB1 | 0.0 | 0.008 | hein_WMM bioplex_WMM hein (KPNB1) |
Images
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Complex HuMAP2_01285 has an average edge precision of 0.311 which is ranked 4448 out of all 6965 complexes.
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