hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01293
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NPRL3 | GATOR complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | UniProt NCBI |
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | UniProt NCBI |
| DEPDC5 | GATOR complex protein DEPDC5 (DEP domain-containing protein 5) | UniProt NCBI |
| NPRL2 | GATOR complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990130 | 4.91515675326e-14 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | GATOR1 complex |
| GO:0035859 | 5.06916499819e-11 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | Seh1-associated complex |
| CORUM:6215 | 1.35146690511e-09 | 0.6 | NPRL2 DEPDC5 NPRL3 | GATOR1 complex |
| GO:0032007 | 2.27945309589e-09 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | negative regulation of TOR signaling |
| GO:0034198 | 3.08829129121e-09 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | cellular response to amino acid starvation |
| GO:1990928 | 3.57083680546e-09 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | response to amino acid starvation |
| CORUM:6753 | 7.56440327173e-08 | 0.6 | SZT2 NPRL3 NPRL2 | SOG complex |
| CORUM:6217 | 7.56440327173e-08 | 0.6 | NPRL2 DEPDC5 NPRL3 | GATOR complex |
| GO:0032006 | 1.96934078318e-07 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | regulation of TOR signaling |
| GO:0031929 | 4.25745004355e-07 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | TOR signaling |
| GO:0009267 | 6.16749937273e-07 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | cellular response to starvation |
| HP:0032046 | 7.85994870532e-07 | 0.6 | NPRL2 DEPDC5 NPRL3 | Focal cortical dysplasia |
| GO:0042594 | 1.09897753919e-06 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | response to starvation |
| GO:0031669 | 2.7349531731e-06 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | cellular response to nutrient levels |
| GO:0031668 | 4.08111530526e-06 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | cellular response to extracellular stimulus |
| GO:0038202 | 8.04174090024e-06 | 0.8 | SZT2 NPRL3 DEPDC5 BMT2 | TORC1 signaling |
| GO:0071496 | 1.15265173905e-05 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | cellular response to external stimulus |
| GO:0031667 | 1.5195214246e-05 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | response to nutrient levels |
| GO:0009991 | 2.18424105376e-05 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | response to extracellular stimulus |
| HP:0032052 | 4.64766403483e-05 | 0.4 | DEPDC5 NPRL3 | Focal cortical dysplasia type IIa |
| GO:1904262 | 0.000330213415772 | 0.6 | SZT2 DEPDC5 BMT2 | negative regulation of TORC1 signaling |
| GO:1902532 | 0.000358531544169 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | negative regulation of intracellular signal transduction |
| KEGG:04150 | 0.000415558284387 | 0.6 | NPRL2 DEPDC5 NPRL3 | mTOR signaling pathway |
| HP:0032051 | 0.00046457916755 | 0.4 | DEPDC5 NPRL3 | Focal cortical dysplasia type II |
| HP:0002539 | 0.000509063514163 | 0.6 | NPRL2 DEPDC5 NPRL3 | Cortical dysplasia |
| HP:0003829 | 0.00286833354554 | 0.6 | NPRL2 DEPDC5 NPRL3 | Incomplete penetrance |
| GO:1903432 | 0.0044914523029 | 0.6 | SZT2 DEPDC5 BMT2 | regulation of TORC1 signaling |
| GO:0098852 | 0.023793677699 | 0.8 | SZT2 NPRL2 DEPDC5 NPRL3 | lytic vacuole membrane |
| GO:0005765 | 0.023793677699 | 0.8 | SZT2 NPRL2 DEPDC5 NPRL3 | lysosomal membrane |
| GO:0009968 | 0.0259321029285 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | negative regulation of signal transduction |
| GO:0010648 | 0.032678035432 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | negative regulation of cell communication |
| GO:0023057 | 0.0334424029162 | 1.0 | SZT2 NPRL2 NPRL3 DEPDC5 BMT2 | negative regulation of signaling |
| HP:0002538 | 0.0381092915033 | 0.6 | NPRL2 DEPDC5 NPRL3 | Abnormality of the cerebral cortex |
| GO:0005774 | 0.0397074972468 | 0.8 | SZT2 NPRL2 DEPDC5 NPRL3 | vacuolar membrane |
| GO:0140007 | 0.0450641792523 | 0.4 | SZT2 BMT2 | KICSTOR complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DEPDC5 | NPRL2 | 0.773 | 0.752 | bioplex (DEPDC5,NPRL2) bioplex_WMM |
| DEPDC5 | BMT2 | 0.533 | 0.638 | bioplex (BMT2) bioplex_WMM |
| BMT2 | SZT2 | 0.353 | 0.539 | bioplex (BMT2) bioplex_WMM |
| NPRL2 | NPRL3 | 0.057 | 0.323 | bioplex (NPRL2,NPRL3) bioplex_WMM |
| DEPDC5 | SZT2 | 0.05 | 0.298 | hein_WMM bioplex (DEPDC5) bioplex_WMM |
| BMT2 | NPRL3 | 0.027 | 0.225 | bioplex (BMT2) bioplex_WMM |
| BMT2 | NPRL2 | 0.02 | 0.187 | bioplex (BMT2) bioplex_WMM |
| DEPDC5 | NPRL3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| NPRL2 | SZT2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| NPRL3 | SZT2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_01293 has an average edge precision of 0.317 which is ranked 4381 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NPRL3 | HuMAP2_01040 HuMAP2_01293 HuMAP2_01704 HuMAP2_04082 HuMAP2_04484 HuMAP2_06118 |
| BMT2 | HuMAP2_00503 HuMAP2_00701 HuMAP2_01040 HuMAP2_01293 |
| SZT2 | HuMAP2_01040 HuMAP2_01293 HuMAP2_02506 |
| DEPDC5 | HuMAP2_00503 HuMAP2_00701 HuMAP2_01040 HuMAP2_01293 HuMAP2_04382 |
| NPRL2 | HuMAP2_00503 HuMAP2_01040 HuMAP2_01293 HuMAP2_04382 |