hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01296
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PAPSS1 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | UniProt NCBI |
| PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | UniProt NCBI |
| CCDC116 | Coiled-coil domain-containing protein 116 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2408550 | 2.00852924023e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se |
| KEGG:00920 | 2.0145484794e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Sulfur metabolism |
| KEGG:00450 | 4.69956058543e-05 | 0.666666666667 | PAPSS1 PAPSS2 | Selenocompound metabolism |
| REAC:R-HSA-174362 | 0.000100412974104 | 0.666666666667 | PAPSS1 PAPSS2 | Transport and synthesis of PAPS |
| WP:WP692 | 0.000100657255092 | 0.666666666667 | PAPSS1 PAPSS2 | Sulfation Biotransformation Reaction |
| GO:0004779 | 0.00135247023414 | 0.666666666667 | PAPSS1 PAPSS2 | sulfate adenylyltransferase activity |
| GO:0004781 | 0.00135247023414 | 0.666666666667 | PAPSS1 PAPSS2 | sulfate adenylyltransferase (ATP) activity |
| GO:0000103 | 0.00135247023414 | 0.666666666667 | PAPSS1 PAPSS2 | sulfate assimilation |
| REAC:R-HSA-156584 | 0.00140483748394 | 0.666666666667 | PAPSS1 PAPSS2 | Cytosolic sulfonation of small molecules |
| KEGG:00230 | 0.00272070891872 | 0.666666666667 | PAPSS1 PAPSS2 | Purine metabolism |
| GO:0034036 | 0.020283420769 | 0.666666666667 | PAPSS1 PAPSS2 | purine ribonucleoside bisphosphate biosynthetic process |
| GO:0050428 | 0.020283420769 | 0.666666666667 | PAPSS1 PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| REAC:R-HSA-156580 | 0.0297704865793 | 0.666666666667 | PAPSS1 PAPSS2 | Phase II - Conjugation of compounds |
| REAC:R-HSA-1630316 | 0.0406759452204 | 0.666666666667 | PAPSS1 PAPSS2 | Glycosaminoglycan metabolism |
| REAC:R-HSA-2408522 | 0.0429088296136 | 0.666666666667 | PAPSS1 PAPSS2 | Selenoamino acid metabolism |
| REAC:R-HSA-3560796 | 0.0498572752401 | 0.333333333333 | PAPSS2 | Defective PAPSS2 causes SEMD-PA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PAPSS2 | PAPSS1 | 1.0 | 0.949 | hein_WMM bioplex (PAPSS1) bioplex_WMM hein (PAPSS1) |
| PAPSS1 | CCDC116 | 0.02 | 0.188 | bioplex (CCDC116) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_01296 has an average edge precision of 0.569 which is ranked 2089 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PAPSS1 | HuMAP2_01296 HuMAP2_02819 |
| PAPSS2 | HuMAP2_00324 HuMAP2_01296 HuMAP2_02819 HuMAP2_03575 |
| CCDC116 | HuMAP2_01296 |