hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01297
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AURKB | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | UniProt NCBI |
| AURKC | Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) | UniProt NCBI |
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | UniProt NCBI |
| LAMTOR4 | Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed] | UniProt NCBI |
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | UniProt NCBI |
| INCENP | Inner centromere protein | UniProt NCBI |
| CCDC102A | Coiled-coil domain-containing protein 102A | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1118 | 9.08345369489e-13 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1119 | 9.08345369489e-13 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1120 | 3.38154272427e-09 | 0.428571428571 | INCENP BIRC5 CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:2582 | 3.38154272427e-09 | 0.428571428571 | AURKB BIRC5 CDCA8 | Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) |
| CORUM:2579 | 3.38154272427e-09 | 0.428571428571 | INCENP BIRC5 AURKB | Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) |
| GO:0032133 | 4.26853511465e-09 | 0.571428571429 | AURKC BIRC5 CDCA8 AURKB | chromosome passenger complex |
| CORUM:1087 | 1.3523445861e-08 | 0.428571428571 | INCENP BIRC5 AURKB | BIRC5-AURKB-INCENP-EVI5 complex |
| REAC:R-HSA-4615885 | 3.17681202124e-07 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | SUMOylation of DNA replication proteins |
| REAC:R-HSA-141444 | 7.86655162634e-06 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 7.86655162634e-06 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 1.44937216864e-05 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 2.30223008303e-05 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Resolution of Sister Chromatid Cohesion |
| CORUM:6184 | 3.02079974644e-05 | 0.285714285714 | INCENP AURKB | AuroraB-AuroraC-INCENP complex |
| CORUM:1116 | 3.02079974644e-05 | 0.285714285714 | AURKB BIRC5 | CRM1-Survivin-AuroraB mitotic complex |
| CORUM:6756 | 3.02079974644e-05 | 0.285714285714 | AURKB BIRC5 | RasGAP-AURKB-survivin complex |
| REAC:R-HSA-5663220 | 3.48399314081e-05 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | RHO GTPases Activate Formins |
| GO:0030496 | 4.66938113162e-05 | 0.714285714286 | AURKC AURKB BIRC5 CDCA8 INCENP | midbody |
| GO:0000775 | 6.33189048071e-05 | 0.714285714286 | AURKC AURKB BIRC5 CDCA8 INCENP | chromosome, centromeric region |
| REAC:R-HSA-3108232 | 8.48660035835e-05 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 9.7846880833e-05 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | SUMOylation |
| REAC:R-HSA-2467813 | 0.000125424876484 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.0001488509542 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.0001488509542 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000151993265715 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 0.000755017672692 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Cell Cycle Checkpoints |
| GO:0005819 | 0.000806186359355 | 0.714285714286 | AURKC AURKB BIRC5 CDCA8 INCENP | spindle |
| REAC:R-HSA-195258 | 0.00101240038307 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | RHO GTPase Effectors |
| GO:0098687 | 0.00203290046341 | 0.714285714286 | AURKC AURKB BIRC5 CDCA8 INCENP | chromosomal region |
| REAC:R-HSA-68886 | 0.00222625241558 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | M Phase |
| REAC:R-HSA-194315 | 0.00374244313656 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Signaling by Rho GTPases |
| REAC:R-HSA-69278 | 0.0076688970217 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Cell Cycle, Mitotic |
| GO:0005875 | 0.0107359250842 | 0.571428571429 | AURKC BIRC5 CDCA8 AURKB | microtubule associated complex |
| GO:0051233 | 0.0142076090165 | 0.428571428571 | AURKC CDCA8 AURKB | spindle midzone |
| REAC:R-HSA-1640170 | 0.0155446721983 | 0.571428571429 | INCENP BIRC5 CDCA8 AURKB | Cell Cycle |
| CORUM:2580 | 0.0249993571594 | 0.142857142857 | BIRC5 | Survivin homodimer complex |
| GO:0000779 | 0.0288395886243 | 0.428571428571 | AURKC BIRC5 AURKB | condensed chromosome, centromeric region |
| CORUM:1117 | 0.0499886427319 | 0.142857142857 | BIRC5 | CRM1-Survivin mitotic complex |
| CORUM:7101 | 0.0499886427319 | 0.142857142857 | AURKB | AURKB-VRK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BIRC5 | CDCA8 | 0.988 | 0.901 | bioplex (BIRC5,CDCA8) bioplex_WMM |
| INCENP | BIRC5 | 0.144 | 0.406 | bioplex (BIRC5) bioplex_WMM |
| BIRC5 | CCDC102A | 0.079 | 0.351 | bioplex (BIRC5) bioplex_WMM |
| BIRC5 | LAMTOR4 | 0.05 | 0.296 | bioplex (BIRC5) bioplex_WMM |
| INCENP | CDCA8 | 0.03 | 0.231 | hein_WMM bioplex_WMM youn_WMM hein (CDCA8) |
| INCENP | AURKB | 0.028 | 0.23 | hein_WMM bioplex_WMM youn_WMM hein (AURKB) |
| AURKC | INCENP | 0.025 | 0.21 | bioplex (AURKC) bioplex_WMM |
| INCENP | CCDC102A | 0.007 | 0.006 | bioplex_WMM WMM_only |
| INCENP | LAMTOR4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CCDC102A | CDCA8 | 0.007 | 0.008 | hein_WMM bioplex_WMM WMM_only |
| LAMTOR4 | CDCA8 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| AURKB | CDCA8 | 0.007 | 0.003 | youn_WMM WMM_only |
| AURKB | CCDC102A | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| LAMTOR4 | AURKB | 0.007 | 0.002 | bioplex_WMM WMM_only |
| LAMTOR4 | CCDC102A | 0.007 | 0.006 | bioplex_WMM WMM_only |
| AURKC | AURKB | 0.005 | 0.016 | bioplex (AURKC) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_01297 has an average edge precision of 0.167 which is ranked 6556 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AURKB | HuMAP2_01297 |
| AURKC | HuMAP2_01297 |
| BIRC5 | HuMAP2_01297 HuMAP2_01678 HuMAP2_05304 |
| LAMTOR4 | HuMAP2_01297 HuMAP2_01678 HuMAP2_02685 |
| CDCA8 | HuMAP2_01297 HuMAP2_01678 HuMAP2_05304 |
| INCENP | HuMAP2_01297 HuMAP2_01678 |
| CCDC102A | HuMAP2_01297 HuMAP2_01678 HuMAP2_04110 |