hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01298
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CLTC | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | UniProt NCBI |
| CZIB | CXXC motif containing zinc binding protein (UPF0587 protein C1orf123) | UniProt NCBI |
| DAB2 | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | UniProt NCBI |
| LRRC59 | Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | UniProt NCBI |
| FCHO1 | F-BAR domain only protein 1 | UniProt NCBI |
| EPS15 | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | UniProt NCBI |
| FCHO2 | F-BAR domain only protein 2 | UniProt NCBI |
| SLC25A41 | Solute carrier family 25 member 41 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 6.65753847156e-08 | 0.625 | DAB2 FCHO1 CLTC EPS15 FCHO2 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 4.3848545635e-07 | 0.625 | DAB2 FCHO1 CLTC EPS15 FCHO2 | Clathrin-mediated endocytosis |
| GO:0048268 | 8.43853741187e-07 | 0.5 | FCHO2 CLTC EPS15 FCHO1 | clathrin coat assembly |
| GO:0072583 | 5.34213382731e-05 | 0.5 | DAB2 FCHO1 CLTC FCHO2 | clathrin-dependent endocytosis |
| GO:0005905 | 6.94441590143e-05 | 0.5 | DAB2 FCHO1 EPS15 FCHO2 | clathrin-coated pit |
| GO:0006898 | 0.000740574016903 | 0.625 | DAB2 FCHO1 CLTC EPS15 FCHO2 | receptor-mediated endocytosis |
| REAC:R-HSA-199991 | 0.000799602221976 | 0.625 | DAB2 FCHO1 CLTC EPS15 FCHO2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0010405888662 | 0.625 | DAB2 FCHO1 CLTC EPS15 FCHO2 | Vesicle-mediated transport |
| MIRNA:hsa-miR-376a-5p | 0.00137161836907 | 0.375 | DAB2 CLTC CZIB | hsa-miR-376a-5p |
| REAC:R-HSA-196025 | 0.00245599792909 | 0.25 | DAB2 CLTC | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.00294640577653 | 0.25 | DAB2 CLTC | Gap junction degradation |
| KEGG:04144 | 0.00936072825747 | 0.375 | DAB2 CLTC EPS15 | Endocytosis |
| GO:0006897 | 0.0161677519416 | 0.625 | DAB2 FCHO1 CLTC EPS15 FCHO2 | endocytosis |
| GO:0030136 | 0.0177371420122 | 0.5 | DAB2 FCHO1 CLTC FCHO2 | clathrin-coated vesicle |
| REAC:R-HSA-190828 | 0.0248968222949 | 0.25 | DAB2 CLTC | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.0263986242322 | 0.25 | DAB2 CLTC | Gap junction trafficking and regulation |
| CORUM:3231 | 0.0497224828424 | 0.125 | EPS15 | Eps15-stonin2 complex |
| CORUM:6691 | 0.0497224828424 | 0.125 | CLTC | CLTC-PI4K2A complex |
| CORUM:7269 | 0.0497224828424 | 0.125 | CLTC | p532-Clathrin-HSP70 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DAB2 | FCHO2 | 0.925 | 0.843 | hein_WMM bioplex (DAB2) bioplex_WMM |
| DAB2 | CLTC | 0.306 | 0.501 | hein_WMM bioplex (DAB2) bioplex_WMM youn_WMM hein (CLTC) fraction |
| FCHO2 | FCHO1 | 0.267 | 0.483 | bioplex (FCHO1) bioplex_WMM |
| CLTC | CZIB | 0.061 | 0.337 | bioplex_WMM fraction |
| DAB2 | SLC25A41 | 0.043 | 0.269 | bioplex (SLC25A41) bioplex_WMM |
| FCHO2 | SLC25A41 | 0.031 | 0.238 | bioplex (SLC25A41) bioplex_WMM |
| EPS15 | FCHO1 | 0.03 | 0.238 | bioplex (FCHO1) bioplex_WMM |
| CLTC | LRRC59 | 0.025 | 0.217 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EPS15 | FCHO2 | 0.021 | 0.185 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| FCHO2 | CLTC | 0.012 | 0.151 | hein_WMM bioplex_WMM youn_WMM hein (CLTC) gupta_WMM |
| EPS15 | DAB2 | 0.008 | 0.083 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| FCHO1 | CLTC | 0.007 | 0.005 | bioplex (FCHO1) |
| EPS15 | LRRC59 | 0.007 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| FCHO2 | LRRC59 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| SLC25A41 | CLTC | 0.006 | 0.005 | bioplex (SLC25A41) bioplex_WMM |
| EPS15 | CLTC | 0.0 | 0.017 | hein_WMM bioplex_WMM youn_WMM hein (CLTC) gupta_WMM fraction |
| EPS15 | SLC25A41 | 0.0 | 0.012 | bioplex (SLC25A41) bioplex_WMM |
Images
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Complex HuMAP2_01298 has an average edge precision of 0.211 which is ranked 6016 out of all 6965 complexes.
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