hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01301
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBCD | Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) | UniProt NCBI |
| TUBB | Tubulin beta chain (Tubulin beta-5 chain) | UniProt NCBI |
| TUBB4A | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | UniProt NCBI |
| TUBB2A | Tubulin beta-2A chain (Tubulin beta class IIa) | UniProt NCBI |
| TUBA4A | Tubulin alpha-4A chain (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | UniProt NCBI |
| TUBB3 | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | UniProt NCBI |
| TUBB2B | Tubulin beta-2B chain | UniProt NCBI |
| TCP11L1 | T-complex protein 11-like protein 1 | UniProt NCBI |
| CAD | CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-389977 | 5.97948142498e-14 | 0.666666666667 | TBCD TUBB3 TUBA4A TUBB2B TUBB4A TUBB2A | Post-chaperonin tubulin folding pathway |
| WP:WP2272 | 6.70742432733e-12 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Pathogenic Escherichia coli infection |
| REAC:R-HSA-190840 | 2.53785052515e-11 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| WP:WP2359 | 2.98622916772e-11 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-190872 | 3.513159699e-11 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Transport of connexons to the plasma membrane |
| KEGG:04540 | 1.13823937182e-10 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Gap junction |
| REAC:R-HSA-190861 | 1.37817390218e-10 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Gap junction assembly |
| REAC:R-HSA-9619483 | 1.74046114569e-10 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 1.74046114569e-10 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-389957 | 3.30352397046e-10 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-5626467 | 4.02077997106e-10 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | RHO GTPases activate IQGAPs |
| REAC:R-HSA-380320 | 6.77923713987e-10 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-389958 | 6.946636541e-10 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-391251 | 1.008350709e-09 | 0.666666666667 | TBCD TUBB3 TUBA4A TUBB2B TUBB4A TUBB2A | Protein folding |
| REAC:R-HSA-190828 | 1.1368560936e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Gap junction trafficking |
| REAC:R-HSA-157858 | 1.32603473019e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Gap junction trafficking and regulation |
| GO:0005874 | 1.36459899366e-09 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | microtubule |
| REAC:R-HSA-8955332 | 1.77972404082e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 2.04891963335e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04145 | 2.08492928795e-09 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Phagosome |
| REAC:R-HSA-437239 | 4.97937685382e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 8.62549377886e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 9.56090154593e-09 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Intraflagellar transport |
| REAC:R-HSA-3371497 | 1.05756449505e-08 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| KEGG:05130 | 1.08014836375e-08 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Pathogenic Escherichia coli infection |
| REAC:R-HSA-983189 | 1.70189906235e-08 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Kinesins |
| REAC:R-HSA-1445148 | 4.22655775552e-08 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 6.08329446281e-08 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Post NMDA receptor activation events |
| REAC:R-HSA-69275 | 6.45611372235e-08 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | G2/M Transition |
| REAC:R-HSA-5617833 | 6.66433814025e-08 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Cilium Assembly |
| REAC:R-HSA-68877 | 6.66433814025e-08 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 6.87811636053e-08 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Mitotic G2-G2/M phases |
| REAC:R-HSA-8852276 | 7.47734089788e-08 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | The role of GTSE1 in G2/M progression after G2 checkpoint |
| GO:0099513 | 7.99559228489e-08 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | polymeric cytoskeletal fiber |
| REAC:R-HSA-442755 | 1.2472416002e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Activation of NMDA receptors and postsynaptic events |
| GO:0005200 | 1.70158852211e-07 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | structural constituent of cytoskeleton |
| REAC:R-HSA-390466 | 1.77317401913e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Chaperonin-mediated protein folding |
| REAC:R-HSA-6811434 | 2.46278143245e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 2.59604420117e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | COPI-mediated anterograde transport |
| REAC:R-HSA-373760 | 5.1465494105e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | L1CAM interactions |
| REAC:R-HSA-5610787 | 5.1465494105e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Hedgehog 'off' state |
| REAC:R-HSA-2132295 | 6.43331323009e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | MHC class II antigen presentation |
| REAC:R-HSA-1852241 | 6.53779364111e-07 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Organelle biogenesis and maintenance |
| REAC:R-HSA-2500257 | 7.63730973812e-07 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Resolution of Sister Chromatid Cohesion |
| GO:0099512 | 9.28272321409e-07 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | supramolecular fiber |
| GO:0099081 | 1.01757466906e-06 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | supramolecular polymer |
| GO:0099080 | 1.03316599342e-06 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | supramolecular complex |
| REAC:R-HSA-8856688 | 1.14452492676e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 1.28423433031e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | RHO GTPases Activate Formins |
| REAC:R-HSA-5358351 | 1.78674516337e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Signaling by Hedgehog |
| REAC:R-HSA-199977 | 1.91721757128e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | ER to Golgi Anterograde Transport |
| REAC:R-HSA-983231 | 3.15702459497e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-68886 | 3.96743304292e-06 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | M Phase |
| REAC:R-HSA-948021 | 4.28935458091e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 5.11042438246e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 6.39500244652e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 7.92459631338e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 8.1346448468e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Mitotic Metaphase and Anaphase |
| GO:0005525 | 8.56347572332e-06 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | GTP binding |
| REAC:R-HSA-6811442 | 9.25242877198e-06 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0032549 | 1.3345793451e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | ribonucleoside binding |
| GO:0032550 | 1.3345793451e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | purine ribonucleoside binding |
| GO:0001883 | 1.37907325408e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | purine nucleoside binding |
| GO:0001882 | 1.52002230295e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | nucleoside binding |
| REAC:R-HSA-112315 | 1.87958156503e-05 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Transmission across Chemical Synapses |
| GO:0032561 | 1.89604322687e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | guanyl ribonucleotide binding |
| GO:0019001 | 1.9555768956e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | guanyl nucleotide binding |
| REAC:R-HSA-69278 | 2.57257184135e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Cell Cycle, Mitotic |
| GO:0035639 | 2.91098526434e-05 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | purine ribonucleoside triphosphate binding |
| HP:0002539 | 3.84552964957e-05 | 0.444444444444 | TUBB2A TUBB3 TUBB2B TUBB | Cortical dysplasia |
| CORUM:6703 | 4.02261743042e-05 | 0.222222222222 | TUBB TBCD | TBCD-tubulin(alpha)-tubulin(beta) complex |
| CORUM:6713 | 4.02261743042e-05 | 0.222222222222 | TUBB TBCD | TBCD-ARL2-tubulin(beta) complex |
| GO:0000226 | 4.30672240942e-05 | 0.777777777778 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | microtubule cytoskeleton organization |
| REAC:R-HSA-446203 | 5.83960528802e-05 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Asparagine N-linked glycosylation |
| GO:0032555 | 7.09553664615e-05 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | purine ribonucleotide binding |
| REAC:R-HSA-1640170 | 7.49207314556e-05 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Cell Cycle |
| CORUM:6715 | 8.0427137187e-05 | 0.222222222222 | TUBB TBCD | TBCD-ARL2-tubulin(beta)-TBCE complex |
| GO:0032553 | 8.16353512634e-05 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | ribonucleotide binding |
| GO:0017076 | 8.39284727733e-05 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | purine nucleotide binding |
| REAC:R-HSA-195258 | 8.72525704942e-05 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | RHO GTPase Effectors |
| GO:0015630 | 9.80046957858e-05 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | microtubule cytoskeleton |
| REAC:R-HSA-112316 | 0.000142208544505 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Neuronal System |
| HP:0003828 | 0.000155575980107 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBB2B TBCD | Variable expressivity |
| CORUM:1400 | 0.0002812304202 | 0.222222222222 | TUBB TUBA4A | ASCOM complex |
| REAC:R-HSA-2262752 | 0.000340931457687 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Cellular responses to stress |
| HP:0002079 | 0.000356235628331 | 0.555555555556 | TBCD TUBB2A TUBB3 TUBB2B TUBB | Hypoplasia of the corpus callosum |
| GO:0007017 | 0.000374994100819 | 0.777777777778 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | microtubule-based process |
| GO:0000166 | 0.000396333772933 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | nucleotide binding |
| GO:1901265 | 0.000400723836493 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | nucleoside phosphate binding |
| REAC:R-HSA-194315 | 0.000447020575454 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Signaling by Rho GTPases |
| HP:0002011 | 0.000570605595581 | 0.888888888889 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A CAD | Morphological abnormality of the central nervous system |
| GO:0044430 | 0.000675124390925 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | cytoskeletal part |
| HP:0001491 | 0.000676023207057 | 0.222222222222 | TUBB3 TUBB2B | Congenital fibrosis of extraocular muscles |
| GO:0097367 | 0.000680344542935 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | carbohydrate derivative binding |
| HP:0003812 | 0.000684757411036 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBB2B TBCD | Phenotypic variability |
| HP:0001252 | 0.000691751343301 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Muscular hypotonia |
| HP:0012823 | 0.000694109597318 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBB2B TBCD | Clinical modifier |
| HP:0002363 | 0.000767007192778 | 0.444444444444 | TBCD TUBB2A TUBB3 TUBB | Abnormality of brainstem morphology |
| REAC:R-HSA-8953897 | 0.000832758677409 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Cellular responses to external stimuli |
| REAC:R-HSA-422475 | 0.00106401863267 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Axon guidance |
| HP:0012639 | 0.00110100217473 | 0.888888888889 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A CAD | Abnormality of nervous system morphology |
| REAC:R-HSA-109582 | 0.00131902915988 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Hemostasis |
| REAC:R-HSA-380259 | 0.00142807644904 | 0.333333333333 | TUBB TUBA4A TUBB4A | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.00142807644904 | 0.333333333333 | TUBB TUBA4A TUBB4A | Loss of proteins required for interphase microtubule organization from the centrosome |
| HP:0002465 | 0.00147015578213 | 0.444444444444 | CAD TUBB3 TUBB4A TBCD | Poor speech |
| REAC:R-HSA-8854518 | 0.0016303496753 | 0.333333333333 | TUBB TUBA4A TUBB4A | AURKA Activation by TPX2 |
| HP:0002365 | 0.001925142124 | 0.333333333333 | TUBB2A TUBB3 TUBB | Hypoplasia of the brainstem |
| HP:0007362 | 0.001925142124 | 0.333333333333 | TUBB2A TUBB3 TUBB | Aplasia/Hypoplasia of the brainstem |
| REAC:R-HSA-199991 | 0.00195631741083 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Membrane Trafficking |
| HP:0003808 | 0.00231089846316 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Abnormal muscle tone |
| REAC:R-HSA-380287 | 0.00234883746975 | 0.333333333333 | TUBB TUBA4A TUBB4A | Centrosome maturation |
| REAC:R-HSA-380270 | 0.00234883746975 | 0.333333333333 | TUBB TUBA4A TUBB4A | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-5653656 | 0.00254123488563 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Vesicle-mediated transport |
| GO:0000278 | 0.00270098013707 | 0.777777777778 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | mitotic cell cycle |
| REAC:R-HSA-2565942 | 0.00282588023244 | 0.333333333333 | TUBB TUBA4A TUBB4A | Regulation of PLK1 Activity at G2/M Transition |
| GO:0036094 | 0.00293384623974 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | small molecule binding |
| HP:0012758 | 0.00306355459929 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Neurodevelopmental delay |
| REAC:R-HSA-1280218 | 0.00333032492825 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Adaptive Immune System |
| HP:0008049 | 0.00337693930593 | 0.222222222222 | TUBB3 TUBB2B | Abnormality of the extraocular muscles |
| GO:0005856 | 0.00371422709577 | 0.888888888889 | TUBB3 TCP11L1 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | cytoskeleton |
| REAC:R-HSA-5620912 | 0.004091371189 | 0.333333333333 | TUBB TUBA4A TUBB4A | Anchoring of the basal body to the plasma membrane |
| GO:0005198 | 0.00420157703102 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | structural molecule activity |
| HP:0007370 | 0.00443269960978 | 0.555555555556 | TBCD TUBB2A TUBB3 TUBB2B TUBB | Aplasia/Hypoplasia of the corpus callosum |
| HP:0012638 | 0.00495411144597 | 0.888888888889 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A CAD | Abnormality of nervous system physiology |
| MIRNA:hsa-miR-708-5p | 0.00590225288393 | 0.333333333333 | TUBB2A TUBB4A TUBB | hsa-miR-708-5p |
| HP:0001273 | 0.00670605474271 | 0.555555555556 | TBCD TUBB2A TUBB3 TUBB2B TUBB | Abnormal corpus callosum morphology |
| HP:0007364 | 0.00684003727618 | 0.666666666667 | TBCD TUBB3 TUBB2B TUBB TUBB4A TUBB2A | Aplasia/Hypoplasia of the cerebrum |
| HP:0002536 | 0.00718893260995 | 0.444444444444 | TUBB2A TUBB3 TUBB2B TUBB | Abnormal cortical gyration |
| HP:0011804 | 0.00768635262449 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Abnormal muscle physiology |
| HP:0012443 | 0.00821978348475 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Abnormality of brain morphology |
| HP:0000707 | 0.00828715040713 | 0.888888888889 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A CAD | Abnormality of the nervous system |
| HP:0001317 | 0.010845930579 | 0.555555555556 | TUBB3 TUBB TUBB4A TUBB2B TBCD | Abnormal cerebellum morphology |
| HP:0011282 | 0.0111804143074 | 0.555555555556 | TUBB3 TUBB TUBB4A TUBB2B TBCD | Abnormality of hindbrain morphology |
| HP:0011283 | 0.0111804143074 | 0.555555555556 | TUBB3 TUBB TUBB4A TUBB2B TBCD | Abnormality of the metencephalon |
| HP:0011446 | 0.0115839924916 | 0.777777777778 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A CAD | Abnormality of higher mental function |
| GO:0007010 | 0.0118812271427 | 0.777777777778 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A | cytoskeleton organization |
| HP:0002538 | 0.0120384390029 | 0.444444444444 | TUBB2A TUBB3 TUBB2B TUBB | Abnormality of the cerebral cortex |
| HP:0002500 | 0.0134593791455 | 0.555555555556 | TBCD TUBB2A TUBB3 TUBB2B TUBB | Abnormality of the cerebral white matter |
| GO:0043168 | 0.0139224806346 | 0.777777777778 | TUBB3 TUBB2A TUBB TUBA4A TUBB2B TUBB4A CAD | anion binding |
| HP:0012759 | 0.0148507229923 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Neurodevelopmental abnormality |
| HP:0002977 | 0.0176082950887 | 0.666666666667 | TBCD TUBB3 TUBB2B TUBB TUBB4A TUBB2A | Aplasia/Hypoplasia involving the central nervous system |
| HP:0001251 | 0.0179730165152 | 0.555555555556 | TUBB3 TUBB TUBB4A TUBB2B TBCD | Ataxia |
| REAC:R-HSA-1266738 | 0.0182079621137 | 0.555555555556 | TUBB3 TUBB2A TUBB4A TUBA4A TUBB2B | Developmental Biology |
| HP:0003011 | 0.0183772722131 | 0.777777777778 | TUBB3 TBCD TUBB TUBB2B TUBB4A TUBB2A CAD | Abnormality of the musculature |
| HP:0002269 | 0.0187401879402 | 0.444444444444 | TUBB2A TUBB3 TUBB2B TUBB | Abnormality of neuronal migration |
| HP:0001263 | 0.0213426659874 | 0.666666666667 | TUBB3 TBCD TUBB TUBB2B TUBB2A CAD | Global developmental delay |
| HP:0010993 | 0.0229960799082 | 0.555555555556 | TBCD TUBB2A TUBB3 TUBB2B TUBB | Abnormality of the cerebral subcortex |
| HP:0011451 | 0.0235719846951 | 0.222222222222 | TBCD TUBB3 | Congenital microcephaly |
| MIRNA:hsa-miR-7162-3p | 0.0254590472273 | 0.333333333333 | TUBB2A TUBB CAD | hsa-miR-7162-3p |
| HP:0001250 | 0.025701589363 | 0.666666666667 | TBCD TUBB3 TUBB2B TUBB4A TUBB2A CAD | Seizures |
| HP:0006808 | 0.0305121976344 | 0.222222222222 | TBCD TUBB4A | Cerebral hypomyelination |
| HP:0002060 | 0.0306365950231 | 0.666666666667 | TBCD TUBB3 TUBB2B TUBB TUBB4A TUBB2A | Abnormality of the cerebrum |
| HP:0011443 | 0.031085581445 | 0.555555555556 | TUBB3 TUBB TUBB4A TUBB2B TBCD | Abnormality of coordination |
| REAC:R-HSA-168256 | 0.0324601785032 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Immune System |
| HP:0100547 | 0.0328422771598 | 0.666666666667 | TBCD TUBB3 TUBB2B TUBB TUBB4A TUBB2A | Abnormality of forebrain morphology |
| HP:0000005 | 0.0359437121659 | 0.888888888889 | TUBB3 TBCD TUBB TUBA4A TUBB2B TUBB4A TUBB2A CAD | Mode of inheritance |
| HP:0000006 | 0.0379428057914 | 0.666666666667 | TUBB3 TUBB TUBA4A TUBB2B TUBB4A TUBB2A | Autosomal dominant inheritance |
| REAC:R-HSA-392499 | 0.0384183773446 | 0.666666666667 | TBCD TUBB3 TUBA4A TUBB2B TUBB4A TUBB2A | Metabolism of proteins |
| MIRNA:hsa-miR-486-3p | 0.0466826875411 | 0.333333333333 | TUBB2A TUBB CAD | hsa-miR-486-3p |
| CORUM:7241 | 0.0499262710315 | 0.111111111111 | TUBB3 | SNCA-TUBB3 complex |
| CORUM:6697 | 0.0499262710315 | 0.111111111111 | TBCD | ARL2-TBCD complex |
| CORUM:6455 | 0.0499262710315 | 0.111111111111 | TBCD | ARL2-TBCD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBB | TUBB3 | 0.948 | 0.856 | hein_WMM bioplex (TUBB,TUBB3) bioplex_WMM boldt boldt_WMM treiber_WMM |
| TUBB2B | TBCD | 0.217 | 0.464 | bioplex (TUBB2B) bioplex_WMM boldt boldt_WMM |
| TUBB | TUBA4A | 0.142 | 0.406 | bioplex (TUBA4A,TUBB) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| TUBB | CAD | 0.131 | 0.402 | hein_WMM bioplex (TUBB) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| TUBB | TUBB4A | 0.125 | 0.399 | bioplex (TUBB) boldt boldt_WMM treiber_WMM bioplex_WMM |
| TUBB | TUBB2A | 0.108 | 0.373 | hein_WMM bioplex (TUBB,TUBB2A) bioplex_WMM boldt boldt_WMM treiber_WMM |
| TUBB2B | TUBB3 | 0.099 | 0.358 | bioplex (TUBB2B,TUBB3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB | TCP11L1 | 0.084 | 0.348 | hein_WMM bioplex (TUBB) bioplex_WMM boldt boldt_WMM |
| TUBB4A | TUBB3 | 0.074 | 0.357 | bioplex (TUBB3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB2A | TUBA4A | 0.073 | 0.354 | bioplex (TUBA4A) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| TUBB | TBCD | 0.067 | 0.35 | bioplex (TUBB) bioplex_WMM boldt boldt_WMM |
| TUBB2A | TUBB2B | 0.062 | 0.345 | boldt youn_WMM gupta_WMM boldt_WMM bioplex_WMM |
| TUBB2B | TCP11L1 | 0.052 | 0.299 | bioplex (TUBB2B) bioplex_WMM boldt boldt_WMM |
| TUBB4A | TUBB2B | 0.048 | 0.295 | bioplex (TUBB2B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TUBB2A | TUBB3 | 0.045 | 0.283 | bioplex (TUBB2A,TUBB3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB2A | TBCD | 0.037 | 0.266 | bioplex (TUBB2A) bioplex_WMM boldt boldt_WMM |
| TUBA4A | TUBB2B | 0.024 | 0.213 | bioplex (TUBA4A,TUBB2B) bioplex_WMM boldt fraction boldt_WMM |
| TUBB2A | TUBB4A | 0.021 | 0.189 | bioplex (TUBB2A) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TCP11L1 | TUBB3 | 0.013 | 0.141 | hein_WMM bioplex (TUBB3) bioplex_WMM |
| TUBB | TUBB2B | 0.008 | 0.032 | bioplex (TUBB2B) bioplex_WMM boldt boldt_WMM treiber_WMM |
| TCP11L1 | TBCD | 0.006 | 0.006 | bioplex_WMM boldt boldt_WMM |
| TUBB4A | TBCD | 0.006 | 0.007 | bioplex_WMM boldt boldt_WMM |
| CAD | TCP11L1 | 0.006 | 0.01 | hein_WMM bioplex_WMM boldt boldt_WMM |
| CAD | TUBB4A | 0.006 | 0.005 | bioplex_WMM boldt boldt_WMM |
| TUBA4A | TCP11L1 | 0.005 | 0.006 | bioplex (TUBA4A) bioplex_WMM boldt boldt_WMM |
| TUBB4A | TCP11L1 | 0.005 | 0.009 | bioplex_WMM boldt boldt_WMM |
| CAD | TUBB2B | 0.005 | 0.005 | bioplex (TUBB2B) bioplex_WMM boldt boldt_WMM |
| CAD | TUBB2A | 0.005 | 0.007 | bioplex (TUBB2A) bioplex_WMM boldt boldt_WMM |
| CAD | TUBB3 | 0.005 | 0.014 | hein_WMM bioplex (TUBB3) bioplex_WMM boldt boldt_WMM treiber_WMM |
| TUBB3 | TBCD | 0.004 | 0.009 | bioplex_WMM WMM_only |
| TUBB4A | TUBA4A | 0.004 | 0.012 | bioplex (TUBA4A) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| TUBA4A | TBCD | 0.004 | 0.015 | bioplex_WMM boldt boldt_WMM |
| TUBA4A | TUBB3 | 0.003 | 0.006 | bioplex (TUBA4A,TUBB3) bioplex_WMM boldt boldt_WMM treiber_WMM |
| CAD | TBCD | 0.0 | 0.014 | bioplex_WMM boldt fraction boldt_WMM |
| CAD | TUBA4A | 0.0 | 0.005 | bioplex (TUBA4A) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| TUBB2A | TCP11L1 | 0.0 | 0.002 | bioplex (TUBB2A) bioplex_WMM boldt boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_01301 has an average edge precision of 0.191 which is ranked 6300 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TBCD | HuMAP2_01301 HuMAP2_02498 HuMAP2_02652 |
| TUBB | HuMAP2_00341 HuMAP2_01301 |
| TUBB4A | HuMAP2_00602 HuMAP2_01301 HuMAP2_05358 HuMAP2_06702 |
| TUBB2A | HuMAP2_00602 HuMAP2_00614 HuMAP2_01301 HuMAP2_02303 HuMAP2_02498 HuMAP2_03275 |
| TUBA4A | HuMAP2_00602 HuMAP2_01301 HuMAP2_02303 HuMAP2_02498 |
| TUBB3 | HuMAP2_00602 HuMAP2_01301 HuMAP2_01601 HuMAP2_05358 HuMAP2_06702 |
| TUBB2B | HuMAP2_00602 HuMAP2_01301 HuMAP2_02498 HuMAP2_04435 HuMAP2_06702 |
| TCP11L1 | HuMAP2_00602 HuMAP2_01301 HuMAP2_02498 |
| CAD | HuMAP2_00368 HuMAP2_01301 HuMAP2_02414 HuMAP2_05612 |