hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01307
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYO18A | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | UniProt NCBI |
| MYH14 | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | UniProt NCBI |
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | UniProt NCBI |
| LRRFIP2 | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | UniProt NCBI |
| IQGAP3 | Ras GTPase-activating-like protein IQGAP3 | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5627117 | 5.75676182894e-06 | 0.5 | MYL12B MYH14 MYL6 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 5.75676182894e-06 | 0.5 | MYL12B MYH14 MYL6 | RHO GTPases activate CIT |
| REAC:R-HSA-416572 | 5.75676182894e-06 | 0.5 | MYL12B MYH14 MYL6 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627123 | 6.77163692478e-06 | 0.5 | MYL12B MYH14 MYL6 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 1.05150257754e-05 | 0.5 | MYL12B MYH14 MYL6 | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 1.54300761667e-05 | 0.5 | MYL12B MYH14 MYL6 | EPHA-mediated growth cone collapse |
| REAC:R-HSA-373755 | 0.000191968063148 | 0.5 | MYL12B MYH14 MYL6 | Semaphorin interactions |
| REAC:R-HSA-195258 | 0.000432427470222 | 0.666666666667 | MYL12B MYH14 MYL6 IQGAP3 | RHO GTPase Effectors |
| REAC:R-HSA-2682334 | 0.000601857302474 | 0.5 | MYL12B MYH14 MYL6 | EPH-Ephrin signaling |
| REAC:R-HSA-5625740 | 0.000762338631268 | 0.5 | MYL12B MYH14 MYL6 | RHO GTPases activate PKNs |
| KEGG:04530 | 0.000819121924932 | 0.5 | MYL12B MYH14 MYL6 | Tight junction |
| REAC:R-HSA-194315 | 0.00160911313747 | 0.666666666667 | MYL12B MYH14 MYL6 IQGAP3 | Signaling by Rho GTPases |
| KEGG:04810 | 0.00175401113695 | 0.5 | MYL12B MYH14 IQGAP3 | Regulation of actin cytoskeleton |
| REAC:R-HSA-445355 | 0.0116417903194 | 0.333333333333 | MYL12B MYL6 | Smooth Muscle Contraction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYL6 | MYO18A | 0.98 | 0.896 | hein_WMM bioplex (MYL6) bioplex_WMM hein (MYO18A) |
| MYL12B | MYL6 | 0.875 | 0.809 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYL12B) gupta_WMM boldt_WMM treiber_WMM |
| MYL12B | MYO18A | 0.102 | 0.364 | hein_WMM bioplex_WMM hein (MYL12B,MYO18A) |
| LRRFIP2 | MYO18A | 0.071 | 0.353 | hein_WMM bioplex_WMM hein (MYO18A) |
| MYH14 | MYL6 | 0.071 | 0.353 | bioplex (MYL6) bioplex_WMM gupta_WMM boldt_WMM treiber_WMM |
| IQGAP3 | MYL6 | 0.044 | 0.281 | bioplex (MYL6) bioplex_WMM boldt youn_WMM boldt_WMM |
| MYH14 | MYL12B | 0.009 | 0.097 | bioplex_WMM gupta_WMM WMM_only boldt_WMM |
| LRRFIP2 | MYH14 | 0.007 | 0.01 | bioplex_WMM gupta_WMM WMM_only |
| MYH14 | MYO18A | 0.007 | 0.004 | bioplex_WMM WMM_only treiber_WMM |
| MYH14 | IQGAP3 | 0.007 | 0.003 | bioplex_WMM WMM_only treiber_WMM |
| MYL12B | IQGAP3 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only boldt_WMM |
| LRRFIP2 | IQGAP3 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| IQGAP3 | MYO18A | 0.006 | 0.008 | bioplex_WMM WMM_only treiber_WMM |
| LRRFIP2 | MYL12B | 0.006 | 0.005 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| LRRFIP2 | MYL6 | 0.006 | 0.008 | hein_WMM bioplex (MYL6) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_01307 has an average edge precision of 0.213 which is ranked 5971 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYO18A | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| MYH14 | HuMAP2_01307 HuMAP2_02178 HuMAP2_04152 |
| MYL12B | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| LRRFIP2 | HuMAP2_00057 HuMAP2_01250 HuMAP2_01307 HuMAP2_02314 HuMAP2_04019 |
| IQGAP3 | HuMAP2_01307 HuMAP2_02178 HuMAP2_04152 |
| MYL6 | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04152 HuMAP2_04655 |