hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01310
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RUVBL2 | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | UniProt NCBI |
| RUVBL1 | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | UniProt NCBI |
| INO80B | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | UniProt NCBI |
| ZNHIT1 | Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet) | UniProt NCBI |
| VPS72 | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | UniProt NCBI |
| DMAP1 | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | UniProt NCBI |
| YEATS4 | YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) | UniProt NCBI |
| ACTR5 | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | UniProt NCBI |
| INO80C | INO80 complex subunit C (IES6 homolog) (hIes6) | UniProt NCBI |
| INO80D | INO80 complex subunit D | UniProt NCBI |
| DPCD | Protein DPCD | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:302 | 3.53436400666e-15 | 0.545454545455 | RUVBL1 INO80D INO80C RUVBL2 INO80B ACTR5 | INO80 chromatin remodeling complex |
| GO:0097346 | 2.45178628506e-13 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 | INO80-type complex |
| CORUM:304 | 1.28841207851e-12 | 0.454545454545 | ZNHIT1 RUVBL1 VPS72 RUVBL2 YEATS4 | SRCAP-associated chromatin remodeling complex |
| CORUM:529 | 2.22874996856e-11 | 0.454545454545 | RUVBL1 YEATS4 VPS72 RUVBL2 DMAP1 | NuA4/Tip60-HAT complex |
| GO:0070603 | 1.21161860265e-09 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 | SWI/SNF superfamily-type complex |
| GO:1904949 | 1.59939721871e-09 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 | ATPase complex |
| CORUM:799 | 2.28254486498e-09 | 0.363636363636 | RUVBL1 VPS72 RUVBL2 DMAP1 | DMAP1-associated complex |
| REAC:R-HSA-5696394 | 8.24004203622e-09 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | DNA Damage Recognition in GG-NER |
| CORUM:2857 | 1.08637671227e-08 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | NuA4/Tip60 HAT complex |
| GO:0031011 | 1.13272485327e-08 | 0.454545454545 | INO80C INO80B RUVBL2 ACTR5 RUVBL1 | Ino80 complex |
| GO:0033202 | 1.13272485327e-08 | 0.454545454545 | INO80C INO80B RUVBL2 ACTR5 RUVBL1 | DNA helicase complex |
| CORUM:528 | 1.4808654147e-08 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | NuA4/Tip60-HAT complex |
| CORUM:798 | 1.4808654147e-08 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | NuA4/Tip60-HAT complex A |
| GO:0006338 | 1.52688865158e-07 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 VPS72 INO80C ACTR5 | chromatin remodeling |
| REAC:R-HSA-5696399 | 4.99014338822e-07 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | Global Genome Nucleotide Excision Repair (GG-NER) |
| CORUM:787 | 1.13325345233e-06 | 0.272727272727 | RUVBL1 RUVBL2 DMAP1 | NuA4/Tip60-HAT complex B |
| REAC:R-HSA-5689603 | 1.21039581891e-06 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | UCH proteinases |
| REAC:R-HSA-5696398 | 1.9610564103e-06 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | Nucleotide Excision Repair |
| GO:0000812 | 3.97303919439e-06 | 0.363636363636 | ZNHIT1 RUVBL1 RUVBL2 DMAP1 | Swr1 complex |
| REAC:R-HSA-3214847 | 7.10218522746e-06 | 0.454545454545 | RUVBL1 YEATS4 VPS72 RUVBL2 DMAP1 | HATs acetylate histones |
| GO:0043968 | 1.45859703988e-05 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | histone H2A acetylation |
| GO:0043189 | 3.10282552996e-05 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | H4/H2A histone acetyltransferase complex |
| GO:0035267 | 3.10282552996e-05 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | NuA4 histone acetyltransferase complex |
| GO:0006325 | 3.85617892229e-05 | 0.727272727273 | RUVBL1 YEATS4 ZNHIT1 RUVBL2 VPS72 INO80C ACTR5 DMAP1 | chromatin organization |
| CORUM:1173 | 0.000100616904936 | 0.181818181818 | RUVBL1 RUVBL2 | TIP49-TIP48-BAF53 complex |
| GO:0043044 | 0.000120845473514 | 0.454545454545 | RUVBL1 VPS72 DMAP1 ACTR5 ZNHIT1 | ATP-dependent chromatin remodeling |
| REAC:R-HSA-5688426 | 0.000162401467297 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | Deubiquitination |
| REAC:R-HSA-4839726 | 0.000171665950607 | 0.454545454545 | RUVBL1 YEATS4 VPS72 RUVBL2 DMAP1 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.000171665950607 | 0.454545454545 | RUVBL1 YEATS4 VPS72 RUVBL2 DMAP1 | Chromatin modifying enzymes |
| CORUM:0000000 | 0.000238379812555 | 0.909090909091 | RUVBL1 DMAP1 INO80D ZNHIT1 RUVBL2 VPS72 INO80C INO80B ACTR5 YEATS4 | CORUM root |
| CORUM:1171 | 0.000335119479973 | 0.181818181818 | RUVBL1 RUVBL2 | c-MYC-ATPase-helicase complex |
| CORUM:1170 | 0.000335119479973 | 0.181818181818 | RUVBL1 RUVBL2 | c-MYC-ATPase-helicase complex |
| CORUM:525 | 0.000335119479973 | 0.181818181818 | RUVBL1 RUVBL2 | TIP60 histone acetylase complex |
| REAC:R-HSA-73894 | 0.000410581001225 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | DNA Repair |
| CORUM:1166 | 0.00050247669008 | 0.181818181818 | RUVBL1 RUVBL2 | p400-associated complex |
| GO:1902562 | 0.000804001152776 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | H4 histone acetyltransferase complex |
| CORUM:781 | 0.00120448701596 | 0.181818181818 | RUVBL1 RUVBL2 | URI complex (Unconventional prefoldin RPB5 Interactor) |
| CORUM:2856 | 0.0015050021591 | 0.181818181818 | RUVBL1 DMAP1 | NuA4/Tip60 HAT complex |
| GO:0051276 | 0.00153765416377 | 0.727272727273 | RUVBL1 YEATS4 ZNHIT1 RUVBL2 VPS72 INO80C ACTR5 DMAP1 | chromosome organization |
| REAC:R-HSA-171319 | 0.0016286415525 | 0.181818181818 | RUVBL1 RUVBL2 | Telomere Extension By Telomerase |
| GO:0043967 | 0.00231430329472 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | histone H4 acetylation |
| GO:0043486 | 0.00311720540941 | 0.363636363636 | RUVBL1 VPS72 DMAP1 ZNHIT1 | histone exchange |
| GO:0000118 | 0.00469004521715 | 0.363636363636 | ZNHIT1 RUVBL1 RUVBL2 DMAP1 | histone deacetylase complex |
| WP:WP2361 | 0.0107996024528 | 0.181818181818 | INO80D RUVBL1 | Gastric Cancer Network 1 |
| GO:1902494 | 0.0111232355916 | 0.727272727273 | RUVBL1 YEATS4 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 DMAP1 | catalytic complex |
| GO:0000123 | 0.0111677810754 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | histone acetyltransferase complex |
| CORUM:5386 | 0.0116588714032 | 0.181818181818 | RUVBL1 INO80C | MLL1-WDR5 complex |
| GO:0000790 | 0.0121906859001 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 | nuclear chromatin |
| GO:1902493 | 0.0181880939156 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | acetyltransferase complex |
| GO:0031248 | 0.0181880939156 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | protein acetyltransferase complex |
| GO:0016579 | 0.0246394608599 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | protein deubiquitination |
| GO:0070646 | 0.0337086388398 | 0.454545454545 | RUVBL1 INO80B ACTR5 INO80C INO80D | protein modification by small protein removal |
| GO:0000785 | 0.0377090225387 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 | chromatin |
| GO:0016573 | 0.039963598761 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | histone acetylation |
| GO:0018393 | 0.0430491034351 | 0.363636363636 | RUVBL1 YEATS4 RUVBL2 DMAP1 | internal peptidyl-lysine acetylation |
| GO:0071339 | 0.0434092832834 | 0.272727272727 | RUVBL1 RUVBL2 INO80C | MLL1 complex |
| GO:0044665 | 0.0434092832834 | 0.272727272727 | RUVBL1 RUVBL2 INO80C | MLL1/2 complex |
| GO:0044451 | 0.0441260183624 | 0.636363636364 | RUVBL1 YEATS4 ZNHIT1 RUVBL2 INO80C VPS72 DMAP1 | nucleoplasm part |
| REAC:R-HSA-180786 | 0.0467760136448 | 0.181818181818 | RUVBL1 RUVBL2 | Extension of Telomeres |
| GO:0044454 | 0.0471465755723 | 0.636363636364 | RUVBL1 DMAP1 ZNHIT1 RUVBL2 INO80C INO80B ACTR5 | nuclear chromosome part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RUVBL2 | RUVBL1 | 1.0 | 0.949 | hein_WMM bioplex (RUVBL1,RUVBL2) bioplex_WMM Guru boldt hein (RUVBL1,RUVBL2) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DMAP1 | VPS72 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction |
| YEATS4 | VPS72 | 1.0 | 0.949 | hein_WMM bioplex (YEATS4) bioplex_WMM youn_WMM hein (YEATS4) |
| DMAP1 | YEATS4 | 1.0 | 0.949 | hein_WMM bioplex (YEATS4) bioplex_WMM youn_WMM hein (YEATS4) |
| RUVBL2 | DMAP1 | 0.999 | 0.949 | hein_WMM bioplex (RUVBL2) bioplex_WMM Guru hein (RUVBL2) gupta_WMM fraction |
| DMAP1 | RUVBL1 | 0.999 | 0.949 | hein_WMM bioplex (RUVBL1) bioplex_WMM Guru hein (RUVBL1) gupta_WMM fraction |
| ACTR5 | RUVBL1 | 0.995 | 0.924 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (ACTR5,RUVBL1) fraction boldt_WMM |
| RUVBL2 | DPCD | 0.995 | 0.923 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM boldt_WMM |
| YEATS4 | ZNHIT1 | 0.986 | 0.901 | hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4) |
| RUVBL1 | VPS72 | 0.986 | 0.901 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM |
| RUVBL2 | VPS72 | 0.935 | 0.85 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| RUVBL1 | ZNHIT1 | 0.912 | 0.834 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM |
| INO80D | RUVBL1 | 0.906 | 0.829 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) |
| INO80B | RUVBL1 | 0.896 | 0.821 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM |
| DPCD | RUVBL1 | 0.885 | 0.816 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM boldt_WMM |
| RUVBL1 | YEATS4 | 0.868 | 0.801 | hein_WMM bioplex (RUVBL1,YEATS4) bioplex_WMM hein (RUVBL1,YEATS4) |
| INO80B | RUVBL2 | 0.851 | 0.791 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| RUVBL2 | INO80D | 0.831 | 0.778 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| INO80C | RUVBL1 | 0.825 | 0.774 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) |
| RUVBL2 | ZNHIT1 | 0.762 | 0.749 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| RUVBL2 | INO80C | 0.728 | 0.735 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| RUVBL2 | ACTR5 | 0.702 | 0.723 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (ACTR5,RUVBL2) boldt_WMM |
| RUVBL2 | YEATS4 | 0.513 | 0.632 | hein_WMM bioplex (RUVBL2,YEATS4) bioplex_WMM hein (RUVBL2,YEATS4) |
| INO80C | ACTR5 | 0.337 | 0.527 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80D | ACTR5 | 0.074 | 0.356 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80B | ACTR5 | 0.023 | 0.211 | hein_WMM bioplex_WMM hein (ACTR5) |
| DMAP1 | ZNHIT1 | 0.022 | 0.208 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80C | 0.022 | 0.196 | hein_WMM bioplex_WMM WMM_only |
| ZNHIT1 | VPS72 | 0.018 | 0.179 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80D | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80C | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| INO80D | DPCD | 0.013 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| DPCD | ACTR5 | 0.012 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| INO80B | DPCD | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| INO80C | DPCD | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| DPCD | ZNHIT1 | 0.011 | 0.148 | hein_WMM bioplex_WMM WMM_only |
| INO80D | ZNHIT1 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| ACTR5 | ZNHIT1 | 0.01 | 0.131 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ZNHIT1 | 0.01 | 0.13 | hein_WMM bioplex_WMM WMM_only |
| INO80C | ZNHIT1 | 0.01 | 0.126 | hein_WMM bioplex_WMM WMM_only |
| DPCD | VPS72 | 0.01 | 0.1 | hein_WMM bioplex_WMM WMM_only |
| DPCD | YEATS4 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| DPCD | DMAP1 | 0.009 | 0.111 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| INO80D | VPS72 | 0.009 | 0.11 | hein_WMM bioplex_WMM WMM_only |
| INO80D | YEATS4 | 0.009 | 0.105 | hein_WMM bioplex_WMM WMM_only |
| INO80D | DMAP1 | 0.009 | 0.102 | hein_WMM bioplex_WMM WMM_only |
| ACTR5 | VPS72 | 0.009 | 0.096 | hein_WMM bioplex_WMM WMM_only |
| ACTR5 | YEATS4 | 0.009 | 0.099 | hein_WMM bioplex_WMM WMM_only |
| INO80B | VPS72 | 0.009 | 0.097 | hein_WMM bioplex_WMM WMM_only |
| INO80C | VPS72 | 0.009 | 0.093 | hein_WMM bioplex_WMM WMM_only |
| INO80B | YEATS4 | 0.008 | 0.095 | hein_WMM bioplex_WMM WMM_only |
| INO80C | YEATS4 | 0.008 | 0.089 | hein_WMM bioplex_WMM WMM_only |
| ACTR5 | DMAP1 | 0.008 | 0.087 | hein_WMM bioplex_WMM WMM_only |
| INO80B | DMAP1 | 0.008 | 0.085 | hein_WMM bioplex_WMM WMM_only |
| INO80C | DMAP1 | 0.008 | 0.081 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01310 has an average edge precision of 0.44 which is ranked 2936 out of all 6965 complexes.
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