hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01320
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | UniProt NCBI |
| MAML1 | Mastermind-like protein 1 (Mam-1) | UniProt NCBI |
| ZNF589 | Zinc finger protein 589 (Stem cell zinc finger protein 1) | UniProt NCBI |
| ZNF268 | Zinc finger protein 268 (Zinc finger protein HZF3) | UniProt NCBI |
| NOTCH2 | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2197563 | 2.28267971382e-07 | 0.6 | MAML1 NOTCH2 RBPJ | NOTCH2 intracellular domain regulates transcription |
| WP:WP3845 | 1.35872715505e-06 | 0.6 | MAML1 NOTCH2 RBPJ | Canonical and Non-canonical Notch signaling |
| REAC:R-HSA-9013695 | 2.63058148282e-06 | 0.6 | MAML1 NOTCH2 RBPJ | NOTCH4 Intracellular Domain Regulates Transcription |
| WP:WP268 | 6.12580709064e-06 | 0.6 | MAML1 NOTCH2 RBPJ | Notch Signaling |
| REAC:R-HSA-350054 | 7.93420714119e-06 | 0.6 | MAML1 NOTCH2 RBPJ | Notch-HLH transcription pathway |
| REAC:R-HSA-1980145 | 8.88541585136e-06 | 0.6 | MAML1 NOTCH2 RBPJ | Signaling by NOTCH2 |
| KEGG:04330 | 1.39628931268e-05 | 0.6 | MAML1 NOTCH2 RBPJ | Notch signaling pathway |
| WP:WP61 | 1.85486617316e-05 | 0.6 | MAML1 NOTCH2 RBPJ | Notch Signaling Pathway |
| CORUM:2890 | 2.0123342217e-05 | 0.4 | MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 2.0123342217e-05 | 0.4 | MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| CORUM:3113 | 2.0123342217e-05 | 0.4 | MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| KEGG:04658 | 4.90975651011e-05 | 0.6 | MAML1 NOTCH2 RBPJ | Th1 and Th2 cell differentiation |
| REAC:R-HSA-9013694 | 0.000213382377717 | 0.6 | MAML1 NOTCH2 RBPJ | Signaling by NOTCH4 |
| REAC:R-HSA-212436 | 0.000239251603487 | 1.0 | ZNF589 ZNF268 RBPJ NOTCH2 MAML1 | Generic Transcription Pathway |
| REAC:R-HSA-1912408 | 0.000327410819085 | 0.6 | MAML1 NOTCH2 RBPJ | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-73857 | 0.000412889072144 | 1.0 | ZNF589 ZNF268 RBPJ NOTCH2 MAML1 | RNA Polymerase II Transcription |
| CORUM:2639 | 0.000522504524138 | 0.4 | MAML1 RBPJ | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-1912422 | 0.000534065976599 | 0.6 | MAML1 NOTCH2 RBPJ | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | ZNF589 ZNF268 RBPJ NOTCH2 MAML1 | Gene expression (Transcription) |
| REAC:R-HSA-8941856 | 0.00105126658749 | 0.4 | MAML1 RBPJ | RUNX3 regulates NOTCH signaling |
| REAC:R-HSA-210744 | 0.00122631290825 | 0.4 | MAML1 RBPJ | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-9013508 | 0.00340529843133 | 0.4 | MAML1 RBPJ | NOTCH3 Intracellular Domain Regulates Transcription |
| KEGG:05165 | 0.00420236199627 | 0.6 | MAML1 NOTCH2 RBPJ | Human papillomavirus infection |
| REAC:R-HSA-157118 | 0.0046564839046 | 0.6 | MAML1 NOTCH2 RBPJ | Signaling by NOTCH |
| REAC:R-HSA-186712 | 0.00546022370076 | 0.4 | MAML1 RBPJ | Regulation of beta-cell development |
| WP:WP2840 | 0.00606287998997 | 0.4 | NOTCH2 RBPJ | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) |
| WP:WP2064 | 0.00942314458108 | 0.4 | NOTCH2 RBPJ | Neural Crest Differentiation |
| REAC:R-HSA-2122947 | 0.012121451174 | 0.4 | MAML1 RBPJ | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9012852 | 0.0126969553517 | 0.4 | MAML1 RBPJ | Signaling by NOTCH3 |
| GO:0002193 | 0.0135228859698 | 0.4 | MAML1 RBPJ | MAML1-RBP-Jkappa- ICN1 complex |
| REAC:R-HSA-2644602 | 0.0184727645209 | 0.4 | MAML1 RBPJ | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894858 | 0.0184727645209 | 0.4 | MAML1 RBPJ | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644606 | 0.0184727645209 | 0.4 | MAML1 RBPJ | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 0.0184727645209 | 0.4 | MAML1 RBPJ | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644603 | 0.0184727645209 | 0.4 | MAML1 RBPJ | Signaling by NOTCH1 in Cancer |
| CORUM:3154 | 0.0249780992026 | 0.2 | NOTCH2 | Notch2(N-TM)-Notch2(N-EC)-Delta complex |
| REAC:R-HSA-1980143 | 0.0269854937899 | 0.4 | MAML1 RBPJ | Signaling by NOTCH1 |
| WP:WP4239 | 0.0296692241758 | 0.4 | NOTCH2 RBPJ | Epithelial to mesenchymal transition in colorectal cancer |
| CORUM:2907 | 0.0499494897235 | 0.2 | RBPJ | RBP-Jkappa-Notch1 complex |
| CORUM:2908 | 0.0499494897235 | 0.2 | RBPJ | RBP-Jkappa-SHARP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 1.0 | 0.949 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| RBPJ | ZNF589 | 0.329 | 0.518 | bioplex (RBPJ) bioplex_WMM |
| NOTCH2 | RBPJ | 0.253 | 0.479 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| ZNF268 | RBPJ | 0.095 | 0.359 | bioplex (RBPJ) bioplex_WMM |
| MAML1 | NOTCH2 | 0.009 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| ZNF268 | MAML1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| MAML1 | ZNF589 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ZNF268 | ZNF589 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| NOTCH2 | ZNF589 | 0.008 | 0.055 | bioplex_WMM WMM_only |
| ZNF268 | NOTCH2 | 0.008 | 0.024 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01320 has an average edge precision of 0.278 which is ranked 4908 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RBPJ | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| MAML1 | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| ZNF589 | HuMAP2_01320 HuMAP2_04096 HuMAP2_04608 HuMAP2_06455 |
| ZNF268 | HuMAP2_01320 HuMAP2_04096 HuMAP2_04608 HuMAP2_06455 |
| NOTCH2 | HuMAP2_01320 HuMAP2_03741 HuMAP2_06153 HuMAP2_06268 |