hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01322
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ESYT1 | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | UniProt NCBI |
| ITGA7 | Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] | UniProt NCBI |
| ITGA6 | Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] | UniProt NCBI |
| TSPAN11 | Tetraspanin-11 (Tspan-11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2118 | 0.00391788001289 | 0.5 | ITGA7 ITGA6 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| REAC:R-HSA-3000157 | 0.00436320194063 | 0.5 | ITGA7 ITGA6 | Laminin interactions |
| KEGG:05412 | 0.00508931242344 | 0.5 | ITGA7 ITGA6 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:04512 | 0.00597612422935 | 0.5 | ITGA7 ITGA6 | ECM-receptor interaction |
| KEGG:05410 | 0.00644602944709 | 0.5 | ITGA7 ITGA6 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:05414 | 0.00710001811334 | 0.5 | ITGA7 ITGA6 | Dilated cardiomyopathy (DCM) |
| WP:WP185 | 0.0071289861505 | 0.5 | ITGA7 ITGA6 | Integrin-mediated Cell Adhesion |
| WP:WP4541 | 0.00857683911078 | 0.5 | ITGA7 ITGA6 | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-216083 | 0.0277220764292 | 0.5 | ITGA7 ITGA6 | Integrin cell surface interactions |
| WP:WP306 | 0.0290430519819 | 0.5 | ITGA7 ITGA6 | Focal Adhesion |
| KEGG:04810 | 0.0342711457345 | 0.5 | ITGA7 ITGA6 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.0350038155474 | 0.5 | ITGA7 ITGA6 | Focal adhesion |
| CORUM:7314 | 0.0499140284799 | 0.25 | ESYT1 | ESYT1-ESYT3 complex |
| CORUM:2413 | 0.0499140284799 | 0.25 | ITGA6 | ITGA6-ITGB1 complex |
| CORUM:2397 | 0.0499140284799 | 0.25 | ITGA7 | ITGA7-ITGB1-ITGB1BP3 complex |
| CORUM:7313 | 0.0499140284799 | 0.25 | ESYT1 | ESYT1-ESYT2 complex |
| CORUM:2323 | 0.0499140284799 | 0.25 | ITGA6 | ITGA6-ITGB4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITGA6 | TSPAN11 | 0.118 | 0.391 | bioplex (TSPAN11) bioplex_WMM |
| TSPAN11 | ESYT1 | 0.026 | 0.22 | bioplex (TSPAN11) bioplex_WMM |
| TSPAN11 | ITGA7 | 0.026 | 0.217 | bioplex (TSPAN11) bioplex_WMM |
| ITGA6 | ITGA7 | 0.01 | 0.139 | bioplex_WMM WMM_only |
| ESYT1 | ITGA7 | 0.006 | 0.011 | bioplex_WMM WMM_only |
| ITGA6 | ESYT1 | 0.006 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_01322 has an average edge precision of 0.165 which is ranked 6583 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ESYT1 | HuMAP2_00287 HuMAP2_00907 HuMAP2_01322 HuMAP2_06362 |
| ITGA7 | HuMAP2_00634 HuMAP2_01322 |
| ITGA6 | HuMAP2_00016 HuMAP2_00634 HuMAP2_01322 HuMAP2_04065 |
| TSPAN11 | HuMAP2_00016 HuMAP2_00634 HuMAP2_01322 |