hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01324
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLIRP | SRA stem-loop-interacting RNA-binding protein, mitochondrial | UniProt NCBI |
| GCN1 | eIF-2-alpha kinase activator GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | UniProt NCBI |
| CDH1 | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | UniProt NCBI |
| CTNND1 | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | UniProt NCBI |
| LRPPRC | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | UniProt NCBI |
| SFXN1 | Sideroflexin-1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0007651 | 0.00045066196833 | 0.333333333333 | CDH1 CTNND1 | Ectropion of lower eyelids |
| REAC:R-HSA-8876493 | 0.000797179114843 | 0.333333333333 | CDH1 CTNND1 | InlA-mediated entry of Listeria monocytogenes into host cells |
| HP:0002744 | 0.00112625143517 | 0.333333333333 | CDH1 CTNND1 | Bilateral cleft lip and palate |
| HP:0009743 | 0.0015764696333 | 0.333333333333 | CDH1 CTNND1 | Distichiasis |
| HP:0008496 | 0.0015764696333 | 0.333333333333 | CDH1 CTNND1 | Multiple rows of eyelashes |
| HP:0100336 | 0.00210158306671 | 0.333333333333 | CDH1 CTNND1 | Bilateral cleft lip |
| HP:0012905 | 0.00270155144475 | 0.333333333333 | CDH1 CTNND1 | Euryblepharon |
| HP:0200040 | 0.00270155144475 | 0.333333333333 | CDH1 CTNND1 | Epidermoid cyst |
| REAC:R-HSA-8876384 | 0.00377982352449 | 0.333333333333 | CDH1 CTNND1 | Listeria monocytogenes entry into host cells |
| HP:0100337 | 0.00495018352279 | 0.333333333333 | CDH1 CTNND1 | Bilateral cleft palate |
| HP:0100338 | 0.00682280818411 | 0.333333333333 | CDH1 CTNND1 | Non-midline cleft palate |
| HP:0025245 | 0.00682280818411 | 0.333333333333 | CDH1 CTNND1 | Cutaneous cyst |
| REAC:R-HSA-418990 | 0.00774747127227 | 0.333333333333 | CDH1 CTNND1 | Adherens junctions interactions |
| KEGG:04520 | 0.0145139710642 | 0.333333333333 | CDH1 CTNND1 | Adherens junction |
| REAC:R-HSA-421270 | 0.0208171179433 | 0.333333333333 | CDH1 CTNND1 | Cell-cell junction organization |
| CORUM:6599 | 0.0249904952816 | 0.166666666667 | CTNND1 | CTNND1-GLIS2 complex |
| HP:0100335 | 0.0262553193116 | 0.333333333333 | CDH1 CTNND1 | Non-midline cleft lip |
| HP:0000698 | 0.030358517586 | 0.333333333333 | CDH1 CTNND1 | Conical tooth |
| CORUM:5319 | 0.0499726005494 | 0.166666666667 | CDH1 | CDH1-CKS1B complex |
| CORUM:5281 | 0.0499726005494 | 0.166666666667 | CDH1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:5320 | 0.0499726005494 | 0.166666666667 | CDH1 | CDH1-SKP2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LRPPRC | SLIRP | 0.853 | 0.791 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LRPPRC) fraction boldt_WMM |
| SLIRP | CDH1 | 0.148 | 0.409 | hein_WMM bioplex_WMM hein (CDH1) |
| LRPPRC | CDH1 | 0.092 | 0.355 | hein_WMM bioplex_WMM hein (CDH1) treiber_WMM |
| CDH1 | CTNND1 | 0.026 | 0.215 | hein_WMM bioplex_WMM hein (CDH1) treiber_WMM |
| LRPPRC | GCN1 | 0.025 | 0.215 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| GCN1 | SFXN1 | 0.024 | 0.215 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SFXN1 | CTNND1 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GCN1 | CTNND1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| SLIRP | CTNND1 | 0.007 | 0.002 | hein_WMM bioplex_WMM WMM_only |
| LRPPRC | CTNND1 | 0.006 | 0.004 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| SLIRP | GCN1 | 0.004 | 0.009 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| LRPPRC | SFXN1 | 0.003 | 0.011 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SLIRP | SFXN1 | 0.0 | 0.011 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_01324 has an average edge precision of 0.173 which is ranked 6499 out of all 6965 complexes.
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