hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01349
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AIMP2 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | UniProt NCBI |
| LARS | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) | UniProt NCBI |
| IARS | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3040 | 3.71837842278e-08 | 1.0 | LARS IARS AIMP2 | Multisynthetase complex |
| REAC:R-HSA-379716 | 9.09984147875e-07 | 1.0 | LARS IARS AIMP2 | Cytosolic tRNA aminoacylation |
| REAC:R-HSA-379724 | 5.16137253834e-06 | 1.0 | LARS IARS AIMP2 | tRNA Aminoacylation |
| GO:0017101 | 1.49850650438e-05 | 1.0 | LARS IARS AIMP2 | aminoacyl-tRNA synthetase multienzyme complex |
| REAC:R-HSA-2408522 | 0.000108111871608 | 1.0 | LARS IARS AIMP2 | Selenoamino acid metabolism |
| KEGG:00970 | 0.000422858026176 | 0.666666666667 | LARS IARS | Aminoacyl-tRNA biosynthesis |
| GO:0006418 | 0.0011207920467 | 1.0 | LARS IARS AIMP2 | tRNA aminoacylation for protein translation |
| GO:0043038 | 0.00137862598403 | 1.0 | LARS IARS AIMP2 | amino acid activation |
| GO:0043039 | 0.00137862598403 | 1.0 | LARS IARS AIMP2 | tRNA aminoacylation |
| REAC:R-HSA-72766 | 0.00180867442135 | 1.0 | LARS IARS AIMP2 | Translation |
| REAC:R-HSA-71291 | 0.00315795701338 | 1.0 | LARS IARS AIMP2 | Metabolism of amino acids and derivatives |
| HP:0001397 | 0.041834410056 | 0.666666666667 | LARS IARS | Hepatic steatosis |
| HP:0006561 | 0.0498941597886 | 0.666666666667 | LARS IARS | Lipid accumulation in hepatocytes |
| HP:0031137 | 0.0498941597886 | 0.666666666667 | LARS IARS | Storage in hepatocytes |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IARS | LARS | 1.0 | 0.949 | hein_WMM bioplex (LARS) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| AIMP2 | IARS | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| AIMP2 | LARS | 1.0 | 0.949 | hein_WMM bioplex (LARS) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01349 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AIMP2 | HuMAP2_01246 HuMAP2_01349 HuMAP2_03598 HuMAP2_05659 |
| LARS | HuMAP2_01246 HuMAP2_01349 HuMAP2_03598 HuMAP2_04318 HuMAP2_04821 HuMAP2_05659 |
| IARS | HuMAP2_01246 HuMAP2_01349 HuMAP2_03598 HuMAP2_05659 |