hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01354
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GAPVD1 | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | UniProt NCBI |
| SPATA46 | Spermatogenesis-associated protein 46 | UniProt NCBI |
| CSNK1D | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | UniProt NCBI |
| CSNK1E | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3298 | 0.00077921353079 | 0.5 | CSNK1E CSNK1D | Melatonin metabolism and effects |
| KEGG:04710 | 0.000811520562786 | 0.5 | CSNK1E CSNK1D | Circadian rhythm |
| WP:WP4249 | 0.00117729775616 | 0.5 | CSNK1E CSNK1D | Hedgehog Signaling Pathway |
| KEGG:04340 | 0.00188834163584 | 0.5 | CSNK1E CSNK1D | Hedgehog signaling pathway |
| WP:WP363 | 0.00196747799108 | 0.5 | CSNK1E CSNK1D | Wnt Signaling Pathway |
| GO:1904956 | 0.00270494046827 | 0.5 | CSNK1E CSNK1D | regulation of midbrain dopaminergic neuron differentiation |
| GO:1904958 | 0.00270494046827 | 0.5 | CSNK1E CSNK1D | positive regulation of midbrain dopaminergic neuron differentiation |
| GO:1905424 | 0.00270494046827 | 0.5 | CSNK1E CSNK1D | regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1905426 | 0.00270494046827 | 0.5 | CSNK1E CSNK1D | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1904340 | 0.00811409485621 | 0.5 | CSNK1E CSNK1D | positive regulation of dopaminergic neuron differentiation |
| MIRNA:hsa-miR-6772-3p | 0.0187858608682 | 0.5 | CSNK1E CSNK1D | hsa-miR-6772-3p |
| KEGG:04390 | 0.0198080875546 | 0.5 | CSNK1E CSNK1D | Hippo signaling pathway |
| REAC:R-HSA-400253 | 0.0207977326435 | 0.5 | CSNK1E CSNK1D | Circadian Clock |
| WP:WP3594 | 0.021597405556 | 0.5 | CSNK1E CSNK1D | Circadian rhythm related genes |
| REAC:R-HSA-380259 | 0.0221036214141 | 0.5 | CSNK1E CSNK1D | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0221036214141 | 0.5 | CSNK1E CSNK1D | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.0241365318386 | 0.5 | CSNK1E CSNK1D | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.0307679435258 | 0.5 | CSNK1E CSNK1D | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.0307679435258 | 0.5 | CSNK1E CSNK1D | Centrosome maturation |
| REAC:R-HSA-2565942 | 0.0347967852364 | 0.5 | CSNK1E CSNK1D | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 0.0399558314157 | 0.5 | CSNK1E CSNK1D | Recruitment of NuMA to mitotic centrosomes |
| GO:1904338 | 0.0405595771497 | 0.5 | CSNK1E CSNK1D | regulation of dopaminergic neuron differentiation |
| MIRNA:hsa-miR-4448 | 0.0431373399917 | 0.5 | CSNK1E CSNK1D | hsa-miR-4448 |
| MIRNA:hsa-miR-4268 | 0.044421033949 | 0.5 | CSNK1E CSNK1D | hsa-miR-4268 |
| REAC:R-HSA-5620912 | 0.0445250072801 | 0.5 | CSNK1E CSNK1D | Anchoring of the basal body to the plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK1E | CSNK1D | 0.975 | 0.887 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1D) |
| CSNK1E | GAPVD1 | 0.624 | 0.678 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1E) |
| GAPVD1 | CSNK1D | 0.618 | 0.675 | hein_WMM bioplex (CSNK1D) bioplex_WMM youn_WMM hein (CSNK1D) gupta_WMM |
| SPATA46 | GAPVD1 | 0.558 | 0.649 | bioplex (SPATA46) bioplex_WMM |
Images
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Complex HuMAP2_01354 has an average edge precision of 0.722 which is ranked 1307 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GAPVD1 | HuMAP2_00180 HuMAP2_00264 HuMAP2_01354 HuMAP2_03029 HuMAP2_04800 |
| SPATA46 | HuMAP2_00180 HuMAP2_00264 HuMAP2_00673 HuMAP2_01354 HuMAP2_03423 HuMAP2_04649 |
| CSNK1D | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |
| CSNK1E | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |