hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01359
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WNT9B | Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15) | UniProt NCBI |
| TSPO | Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) | UniProt NCBI |
| VDAC1 | Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) | UniProt NCBI |
| NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | UniProt NCBI |
| UQCRFS1 | Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (Ubiquinol-cytochrome c reductase 8 kDa protein)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05012 | 0.000278060757653 | 0.6 | NDUFA2 VDAC1 UQCRFS1 | Parkinson disease |
| KEGG:05016 | 0.000759162382225 | 0.6 | NDUFA2 VDAC1 UQCRFS1 | Huntington disease |
| REAC:R-HSA-1428517 | 0.00196642775139 | 0.6 | NDUFA2 VDAC1 UQCRFS1 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:04979 | 0.00385577589725 | 0.4 | TSPO VDAC1 | Cholesterol metabolism |
| WP:WP111 | 0.0141122881464 | 0.4 | NDUFA2 UQCRFS1 | Electron Transport Chain (OXPHOS system in mitochondria) |
| KEGG:00190 | 0.0291793560441 | 0.4 | NDUFA2 UQCRFS1 | Oxidative phosphorylation |
| WP:WP4396 | 0.0305499086042 | 0.4 | NDUFA2 UQCRFS1 | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0370300962025 | 0.4 | NDUFA2 UQCRFS1 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:05010 | 0.0495576477539 | 0.4 | NDUFA2 UQCRFS1 | Alzheimer disease |
| CORUM:7418 | 0.0499494897235 | 0.2 | VDAC1 | HK1-VDAC1 complex |
| CORUM:7529 | 0.0499494897235 | 0.2 | VDAC1 | APP-Abeta42-VDAC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VDAC1 | NDUFA2 | 0.047 | 0.294 | hein_WMM bioplex_WMM fraction |
| NDUFA2 | WNT9B | 0.031 | 0.239 | bioplex (WNT9B) bioplex_WMM |
| UQCRFS1 | NDUFA2 | 0.03 | 0.239 | hein_WMM bioplex_WMM fraction |
| VDAC1 | TSPO | 0.02 | 0.185 | bioplex_WMM Guru boldt fraction boldt_WMM |
| UQCRFS1 | TSPO | 0.007 | 0.008 | bioplex_WMM WMM_only |
| UQCRFS1 | WNT9B | 0.006 | 0.005 | bioplex (WNT9B) bioplex_WMM |
| UQCRFS1 | VDAC1 | 0.0 | 0.003 | hein_WMM bioplex (VDAC1) bioplex_WMM youn_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_01359 has an average edge precision of 0.139 which is ranked 6780 out of all 6965 complexes.
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