hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01362
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DPP9 | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | UniProt NCBI |
| IRF9 | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | UniProt NCBI |
| WARS2 | Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS) | UniProt NCBI |
| STAT1 | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | UniProt NCBI |
| STAT2 | Signal transducer and activator of transcription 2 (p113) | UniProt NCBI |
| SPRED2 | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | UniProt NCBI |
| ZNF692 | Zinc finger protein 692 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:60 | 3.38154272427e-09 | 0.428571428571 | IRF9 STAT1 STAT2 | Interferon-stimulated gene factor 3 transcription complex ISGF3 |
| WP:WP2113 | 1.89175701516e-07 | 0.428571428571 | IRF9 STAT1 STAT2 | Type III interferon signaling |
| WP:WP4197 | 3.84177292062e-06 | 0.428571428571 | IRF9 STAT1 STAT2 | The human immune response to tuberculosis |
| WP:WP619 | 8.75134396753e-06 | 0.428571428571 | IRF9 STAT1 STAT2 | Type II interferon signaling (IFNG) |
| WP:WP585 | 8.30174566412e-05 | 0.428571428571 | IRF9 STAT1 STAT2 | Interferon type I signaling pathways |
| KEGG:04625 | 0.00035941242151 | 0.428571428571 | IRF9 STAT1 STAT2 | C-type lectin receptor signaling pathway |
| WP:WP4495 | 0.000452410410067 | 0.285714285714 | STAT1 STAT2 | IL-10 Anti-inflammatory Signaling Pathway |
| KEGG:04380 | 0.000577476144901 | 0.428571428571 | IRF9 STAT1 STAT2 | Osteoclast differentiation |
| KEGG:04630 | 0.000936929450632 | 0.428571428571 | IRF9 STAT1 STAT2 | JAK-STAT signaling pathway |
| KEGG:05162 | 0.00110907784383 | 0.428571428571 | IRF9 STAT1 STAT2 | Measles |
| KEGG:05160 | 0.00132999989293 | 0.428571428571 | IRF9 STAT1 STAT2 | Hepatitis C |
| KEGG:05164 | 0.00171297141858 | 0.428571428571 | IRF9 STAT1 STAT2 | Influenza A |
| KEGG:04217 | 0.00185514524785 | 0.428571428571 | IRF9 STAT1 STAT2 | Necroptosis |
| KEGG:04621 | 0.00208266407081 | 0.428571428571 | IRF9 STAT1 STAT2 | NOD-like receptor signaling pathway |
| KEGG:05167 | 0.00237048300499 | 0.428571428571 | IRF9 STAT1 STAT2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.00322802267819 | 0.428571428571 | IRF9 STAT1 STAT2 | Epstein-Barr virus infection |
| REAC:R-HSA-8854691 | 0.00482714346521 | 0.285714285714 | STAT1 STAT2 | Interleukin-20 family signaling |
| REAC:R-HSA-913531 | 0.0088619565331 | 0.428571428571 | IRF9 STAT1 STAT2 | Interferon Signaling |
| KEGG:05165 | 0.0156896284271 | 0.428571428571 | IRF9 STAT1 STAT2 | Human papillomavirus infection |
| WP:WP4341 | 0.0194028583033 | 0.285714285714 | STAT1 STAT2 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| REAC:R-HSA-1280215 | 0.0238923711979 | 0.571428571429 | SPRED2 STAT1 IRF9 STAT2 | Cytokine Signaling in Immune system |
| KEGG:05168 | 0.0277884425258 | 0.428571428571 | IRF9 STAT1 STAT2 | Herpes simplex virus 1 infection |
| CORUM:5573 | 0.0499886427319 | 0.142857142857 | STAT1 | Stat1-alpha-dimer-CBP DNA-protein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IRF9 | STAT2 | 0.213 | 0.464 | bioplex (IRF9,STAT2) bioplex_WMM |
| STAT2 | ZNF692 | 0.133 | 0.405 | bioplex (STAT2) bioplex_WMM |
| STAT1 | STAT2 | 0.056 | 0.316 | bioplex (STAT1,STAT2) bioplex_WMM youn_WMM gupta_WMM |
| WARS2 | IRF9 | 0.051 | 0.3 | bioplex (IRF9) bioplex_WMM |
| DPP9 | STAT2 | 0.038 | 0.261 | bioplex (STAT2) bioplex_WMM |
| DPP9 | SPRED2 | 0.021 | 0.187 | bioplex (SPRED2) bioplex_WMM |
| IRF9 | STAT1 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| STAT1 | ZNF692 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| IRF9 | ZNF692 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| WARS2 | STAT2 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| DPP9 | ZNF692 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| IRF9 | DPP9 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| DPP9 | STAT1 | 0.007 | 0.006 | bioplex_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_01362 has an average edge precision of 0.17 which is ranked 6524 out of all 6965 complexes.
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