hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01370
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKDC | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:322 | 5.02777038712e-06 | 1.0 | PRKDC XRCC5 | DNA-PK-Ku complex |
| CORUM:5182 | 5.02777038712e-06 | 1.0 | PRKDC XRCC5 | DNA-PK-Ku complex |
| CORUM:355 | 5.02777038712e-06 | 1.0 | PRKDC XRCC5 | DNA-PK-Ku complex |
| CORUM:357 | 5.02777038712e-06 | 1.0 | PRKDC XRCC5 | DNA-PK-Ku complex |
| CORUM:356 | 5.02777038712e-06 | 1.0 | PRKDC XRCC5 | DNA-PK-Ku complex |
| WP:WP438 | 7.82420796608e-06 | 1.0 | PRKDC XRCC5 | Non-homologous end joining |
| CORUM:5176 | 1.00555407742e-05 | 1.0 | PRKDC XRCC5 | MGC1-DNA-PKcs-Ku complex |
| CORUM:7217 | 1.00555407742e-05 | 1.0 | PRKDC XRCC5 | Dysbindin 1-A-DNA-PK-complex |
| CORUM:1571 | 1.00555407742e-05 | 1.0 | PRKDC XRCC5 | Vigilin-DNA-PK-Ku antigen complex |
| KEGG:03450 | 1.13800084426e-05 | 1.0 | PRKDC XRCC5 | Non-homologous end-joining |
| CORUM:5179 | 1.67592346237e-05 | 1.0 | PRKDC XRCC5 | NCOA6-DNA-PK-Ku-PARP1 complex |
| CORUM:3102 | 2.51388519356e-05 | 1.0 | PRKDC XRCC5 | DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex |
| CORUM:5183 | 4.69258569465e-05 | 1.0 | PRKDC XRCC5 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| CORUM:7285 | 6.03332446455e-05 | 1.0 | PRKDC XRCC5 | HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex |
| REAC:R-HSA-3270619 | 0.000130722030065 | 1.0 | PRKDC XRCC5 | IRF3-mediated induction of type I IFN |
| REAC:R-HSA-1834941 | 0.000201110815485 | 1.0 | PRKDC XRCC5 | STING mediated induction of host immune responses |
| WP:WP4016 | 0.00111886173915 | 1.0 | PRKDC XRCC5 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-1834949 | 0.00327307852202 | 1.0 | PRKDC XRCC5 | Cytosolic sensors of pathogen-associated DNA |
| REAC:R-HSA-5693571 | 0.00393171644273 | 1.0 | PRKDC XRCC5 | Nonhomologous End-Joining (NHEJ) |
| HPA:008010_13 | 0.0062872268691 | 1.0 | PRKDC XRCC5 | cerebral cortex; endothelial cells[Supported,High] |
| HPA:014010_13 | 0.0110636087369 | 1.0 | PRKDC XRCC5 | endometrium 2; cells in endometrial stroma[Supported,High] |
| HPA:031020_13 | 0.0117549271651 | 1.0 | PRKDC XRCC5 | ovary; ovarian stroma cells[Supported,High] |
| HPA:013010_13 | 0.0123230652188 | 1.0 | PRKDC XRCC5 | endometrium 1; cells in endometrial stroma[Supported,High] |
| GO:0070419 | 0.0162296428096 | 1.0 | PRKDC XRCC5 | nonhomologous end joining complex |
| HPA:014010_03 | 0.0165086840661 | 1.0 | PRKDC XRCC5 | endometrium 2; cells in endometrial stroma[Uncertain,High] |
| HPA:031020_03 | 0.017350835606 | 1.0 | PRKDC XRCC5 | ovary; ovarian stroma cells[Uncertain,High] |
| HPA:008010_03 | 0.017350835606 | 1.0 | PRKDC XRCC5 | cerebral cortex; endothelial cells[Uncertain,High] |
| HPA:022010_13 | 0.0187418520797 | 1.0 | PRKDC XRCC5 | hippocampus; glial cells[Supported,High] |
| HPA:011010_13 | 0.0200029844852 | 1.0 | PRKDC XRCC5 | colon; endothelial cells[Supported,High] |
| HPA:013010_03 | 0.0211166356259 | 1.0 | PRKDC XRCC5 | endometrium 1; cells in endometrial stroma[Uncertain,High] |
| HPA:050010_13 | 0.0214945563667 | 1.0 | PRKDC XRCC5 | spleen; cells in red pulp[Supported,High] |
| HPA:050020_13 | 0.0220677221908 | 1.0 | PRKDC XRCC5 | spleen; cells in white pulp[Supported,High] |
| REAC:R-HSA-5693532 | 0.0224003929981 | 1.0 | PRKDC XRCC5 | DNA Double-Strand Break Repair |
| HPA:004030_13 | 0.0232366788058 | 1.0 | PRKDC XRCC5 | breast; myoepithelial cells[Supported,High] |
| HPA:043010_13 | 0.0246385887821 | 1.0 | PRKDC XRCC5 | skin 1; Langerhans[Supported,High] |
| HPA:043020_13 | 0.0267125440668 | 1.0 | PRKDC XRCC5 | skin 1; fibroblasts[Supported,High] |
| HPA:002020_13 | 0.0269245483848 | 1.0 | PRKDC XRCC5 | appendix; lymphoid tissue[Supported,High] |
| HPA:024010_13 | 0.0277809452741 | 1.0 | PRKDC XRCC5 | kidney; cells in glomeruli[Supported,High] |
| HPA:028010_13 | 0.028650749551 | 1.0 | PRKDC XRCC5 | lymph node; germinal center cells[Supported,High] |
| HPA:006010_13 | 0.0295339612157 | 1.0 | PRKDC XRCC5 | caudate; glial cells[Supported,High] |
| HPA:022010_03 | 0.0302051685624 | 1.0 | PRKDC XRCC5 | hippocampus; glial cells[Uncertain,High] |
| HPA:007020_13 | 0.0315702082225 | 1.0 | PRKDC XRCC5 | cerebellum; cells in granular layer[Supported,High] |
| HPA:008020_13 | 0.0320319251364 | 1.0 | PRKDC XRCC5 | cerebral cortex; glial cells[Supported,High] |
| HPA:043040_13 | 0.0327307852202 | 1.0 | PRKDC XRCC5 | skin 1; melanocytes[Supported,High] |
| HPA:043030_13 | 0.0339123112612 | 1.0 | PRKDC XRCC5 | skin 1; keratinocytes[Supported,High] |
| HPA:027010_13 | 0.0353577952474 | 1.0 | PRKDC XRCC5 | lung; macrophages[Supported,High] |
| HPA:027020_13 | 0.0363382104729 | 1.0 | PRKDC XRCC5 | lung; pneumocytes[Supported,High] |
| HPA:028020_13 | 0.0368334458561 | 1.0 | PRKDC XRCC5 | lymph node; non-germinal center cells[Supported,High] |
| HPA:047040_12 | 0.0398752469403 | 1.0 | PRKDC XRCC5 | soft tissue 1; peripheral nerve[Supported,Medium] |
| HPA:035010_13 | 0.0401341771152 | 1.0 | PRKDC XRCC5 | placenta; decidual cells[Supported,High] |
| HPA:036010_13 | 0.0417053553612 | 1.0 | PRKDC XRCC5 | prostate; glandular cells[Supported,High] |
| HPA:009020_13 | 0.0417053553612 | 1.0 | PRKDC XRCC5 | cervix, uterine; squamous epithelial cells[Supported,High] |
| HPA:014020_13 | 0.042235785137 | 1.0 | PRKDC XRCC5 | endometrium 2; glandular cells[Supported,High] |
| HPA:007030_13 | 0.0454887525775 | 1.0 | PRKDC XRCC5 | cerebellum; cells in molecular layer[Supported,High] |
| HPA:002020_03 | 0.0457652799488 | 1.0 | PRKDC XRCC5 | appendix; lymphoid tissue[Uncertain,High] |
| HPA:056010_13 | 0.0460426452818 | 1.0 | PRKDC XRCC5 | tonsil; germinal center cells[Supported,High] |
| HPA:050020_03 | 0.0474420413729 | 1.0 | PRKDC XRCC5 | spleen; cells in white pulp[Uncertain,High] |
| HPA:040010_13 | 0.0474420413729 | 1.0 | PRKDC XRCC5 | seminal vesicle; glandular cells[Supported,High] |
| HPA:050010_03 | 0.0477244344763 | 1.0 | PRKDC XRCC5 | spleen; cells in red pulp[Uncertain,High] |
| HPA:007010_13 | 0.0480076655415 | 1.0 | PRKDC XRCC5 | cerebellum; Purkinje cells[Supported,High] |
| HPA:056020_13 | 0.0480076655415 | 1.0 | PRKDC XRCC5 | tonsil; non-germinal center cells[Supported,High] |
| HPA:004020_13 | 0.0485766415569 | 1.0 | PRKDC XRCC5 | breast; glandular cells[Supported,High] |
| HPA:006010_03 | 0.0491489694193 | 1.0 | PRKDC XRCC5 | caudate; glial cells[Uncertain,High] |
| CORUM:361 | 0.0499173803268 | 0.5 | PRKDC | Artemis-DNA-PK complex |
| CORUM:4081 | 0.0499173803268 | 0.5 | XRCC5 | Ku antigen complex |
| CORUM:360 | 0.0499173803268 | 0.5 | PRKDC | Artemis-DNA-PK complex |
| CORUM:328 | 0.0499173803268 | 0.5 | XRCC5 | Ku antigen complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKDC | XRCC5 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (XRCC5) Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_01370 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKDC | HuMAP2_01370 HuMAP2_02284 HuMAP2_05624 HuMAP2_06176 HuMAP2_06621 |
| XRCC5 | HuMAP2_01370 HuMAP2_01667 HuMAP2_02284 HuMAP2_02836 HuMAP2_04529 HuMAP2_05793 |