hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01374
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ILK | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK) | UniProt NCBI |
| LIMS1 | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | UniProt NCBI |
| RSU1 | Ras suppressor protein 1 (RSP-1) (Rsu-1) | UniProt NCBI |
| PARVB | Beta-parvin (Affixin) | UniProt NCBI |
| PARVA | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | UniProt NCBI |
| PARVG | Gamma-parvin | UniProt NCBI |
| CMAS | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446353 | 4.92245159324e-12 | 0.714285714286 | LIMS1 PARVB PARVA ILK RSU1 | Cell-extracellular matrix interactions |
| REAC:R-HSA-446388 | 1.99767882788e-10 | 0.571428571429 | LIMS1 PARVA RSU1 PARVB | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| CORUM:6919 | 3.38154272427e-09 | 0.428571428571 | LIMS1 ILK PARVA | ILK-LIMS1-PARVA complex |
| REAC:R-HSA-446728 | 7.43580077154e-09 | 0.714285714286 | LIMS1 PARVB PARVA ILK RSU1 | Cell junction organization |
| REAC:R-HSA-1500931 | 4.98161125168e-08 | 0.714285714286 | LIMS1 PARVB PARVA ILK RSU1 | Cell-Cell communication |
| GO:0034446 | 4.10096921113e-06 | 0.714285714286 | LIMS1 PARVG PARVA ILK PARVB | substrate adhesion-dependent cell spreading |
| GO:0031589 | 4.3915228769e-06 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | cell-substrate adhesion |
| CORUM:6920 | 3.02079974644e-05 | 0.285714285714 | ILK PARVA | ILK-LIMS2-PARVA complex |
| CORUM:5498 | 3.02079974644e-05 | 0.285714285714 | ILK PARVB | ILK-PARVB-ARHGEF6 complex |
| WP:WP306 | 4.44410602861e-05 | 0.571428571429 | PARVG PARVA ILK PARVB | Focal Adhesion |
| KEGG:04510 | 4.47283956578e-05 | 0.571428571429 | PARVG PARVA ILK PARVB | Focal adhesion |
| GO:0005925 | 5.93156142444e-05 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | focal adhesion |
| GO:0005924 | 6.13624765864e-05 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | cell-substrate adherens junction |
| GO:0030055 | 6.67382117684e-05 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | cell-substrate junction |
| WP:WP2572 | 0.000132668935945 | 0.428571428571 | LIMS1 ILK PARVA | Primary Focal Segmental Glomerulosclerosis FSGS |
| REAC:R-HSA-446343 | 0.000189894057505 | 0.285714285714 | ILK PARVA | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| GO:0005912 | 0.000271946049505 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | adherens junction |
| GO:0070161 | 0.000313799129869 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | anchoring junction |
| GO:0030054 | 0.00317175626836 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | cell junction |
| GO:0007155 | 0.0130877840917 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | cell adhesion |
| GO:0022610 | 0.013634782811 | 0.857142857143 | PARVG PARVA LIMS1 RSU1 PARVB ILK | biological adhesion |
| GO:0000904 | 0.0257043347096 | 0.714285714286 | LIMS1 PARVG PARVA ILK PARVB | cell morphogenesis involved in differentiation |
| CORUM:764 | 0.0499886427319 | 0.142857142857 | PARVB | Dysferlin-affixin complex |
| CORUM:4025 | 0.0499886427319 | 0.142857142857 | PARVB | ACTN1-PARVB complex |
| CORUM:5499 | 0.0499886427319 | 0.142857142857 | PARVB | PARVB-ARHGEF6 complex |
| CORUM:6510 | 0.0499886427319 | 0.142857142857 | ILK | ILK-SERCA2A-PLN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ILK | PARVA | 1.0 | 0.949 | hein_WMM bioplex (ILK,PARVA) bioplex_WMM Guru hein (ILK) Malo fraction treiber_WMM |
| ILK | LIMS1 | 1.0 | 0.949 | hein_WMM bioplex (ILK,LIMS1) bioplex_WMM hein (ILK) fraction |
| ILK | PARVB | 1.0 | 0.949 | hein_WMM bioplex (ILK) bioplex_WMM Guru hein (ILK) fraction |
| ILK | RSU1 | 1.0 | 0.949 | hein_WMM bioplex (ILK,RSU1) bioplex_WMM hein (ILK) Malo fraction |
| PARVB | PARVA | 1.0 | 0.949 | hein_WMM bioplex (PARVA) bioplex_WMM |
| RSU1 | PARVB | 0.996 | 0.928 | hein_WMM bioplex (RSU1) bioplex_WMM Guru fraction |
| PARVB | LIMS1 | 0.99 | 0.909 | hein_WMM bioplex (LIMS1) bioplex_WMM fraction |
| ILK | PARVG | 0.986 | 0.9 | bioplex (PARVG) bioplex_WMM |
| RSU1 | LIMS1 | 0.985 | 0.899 | hein_WMM bioplex (LIMS1,RSU1) bioplex_WMM fraction |
| RSU1 | PARVA | 0.979 | 0.895 | hein_WMM bioplex (PARVA,RSU1) bioplex_WMM Guru Malo fraction |
| PARVG | RSU1 | 0.894 | 0.82 | bioplex (PARVG) bioplex_WMM |
| PARVA | LIMS1 | 0.867 | 0.801 | hein_WMM bioplex (LIMS1,PARVA) bioplex_WMM fraction |
| PARVG | LIMS1 | 0.683 | 0.711 | bioplex (PARVG) bioplex_WMM |
| LIMS1 | CMAS | 0.233 | 0.471 | bioplex (LIMS1) bioplex_WMM |
| PARVA | CMAS | 0.007 | 0.01 | bioplex_WMM WMM_only |
| PARVB | CMAS | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RSU1 | CMAS | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ILK | CMAS | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01374 has an average edge precision of 0.673 which is ranked 1502 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ILK | HuMAP2_01374 HuMAP2_02505 HuMAP2_06435 HuMAP2_06595 |
| LIMS1 | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| RSU1 | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVB | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVA | HuMAP2_01374 HuMAP2_02505 HuMAP2_06435 HuMAP2_06595 |
| PARVG | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| CMAS | HuMAP2_01374 HuMAP2_06595 |