hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01376

Confidence: Medium

Genename	Protein Name	Links
WIPF2	WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)	UniProt NCBI
WIPF1	WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)	UniProt NCBI
NCK1	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)	UniProt NCBI
WIPF3	WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)	UniProt NCBI
MEA1	Male-enhanced antigen 1 (MEA-1)	UniProt NCBI
WASL	Neural Wiskott-Aldrich syndrome protein (N-WASP)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5663213	5.22274747274e-11	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	RHO GTPases Activate WASPs and WAVEs
REAC:R-HSA-2029482	8.04354101299e-10	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Regulation of actin dynamics for phagocytic cup formation
REAC:R-HSA-2029480	3.85785053617e-09	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Fcgamma receptor (FCGR) dependent phagocytosis
GO:0044396	5.48782169959e-09	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin cortical patch organization
GO:0000147	5.48782169959e-09	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin cortical patch assembly
GO:0051666	1.28035412092e-08	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin cortical patch localization
KEGG:05130	6.16382908626e-08	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Pathogenic Escherichia coli infection
GO:0030479	6.65140313081e-07	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin cortical patch
GO:0061645	6.65140313081e-07	0.666666666667	WIPF2 WASL WIPF1 WIPF3	endocytic patch
GO:0038094	8.45002432374e-07	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Fc-gamma receptor signaling pathway
GO:0002433	8.45002432374e-07	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0038096	8.45002432374e-07	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0002431	9.67214108277e-07	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Fc receptor mediated stimulatory signaling pathway
KEGG:05135	2.08004640979e-06	0.666666666667	WIPF2 WASL WIPF1 WIPF3	Yersinia infection
REAC:R-HSA-195258	3.59974804433e-06	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	RHO GTPase Effectors
GO:0030866	8.66795236882e-06	0.666666666667	WIPF2 WASL WIPF1 WIPF3	cortical actin cytoskeleton organization
GO:0030865	1.49273703752e-05	0.666666666667	WIPF2 WASL WIPF1 WIPF3	cortical cytoskeleton organization
REAC:R-HSA-194315	1.88281567217e-05	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Signaling by Rho GTPases
KEGG:04144	3.82138813702e-05	0.666666666667	WIPF2 WASL WIPF1 WIPF3	Endocytosis
GO:0038093	4.2563574401e-05	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Fc receptor signaling pathway
GO:0006909	9.77371094098e-05	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	phagocytosis
GO:0030864	0.000314144203038	0.666666666667	WIPF2 WASL WIPF1 WIPF3	cortical actin cytoskeleton
GO:0002429	0.000693957239919	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	immune response-activating cell surface receptor signaling pathway
GO:0030863	0.000700012687215	0.666666666667	WIPF2 WASL WIPF1 WIPF3	cortical cytoskeleton
REAC:R-HSA-168249	0.000732700762042	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Innate Immune System
GO:0002768	0.000995084496271	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	immune response-regulating cell surface receptor signaling pathway
GO:0005884	0.00125526288107	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin filament
REAC:R-HSA-418885	0.00172598429993	0.333333333333	NCK1 WASL	DCC mediated attractive signaling
GO:0030048	0.00173031461284	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin filament-based movement
GO:0002757	0.00458117674614	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	immune response-activating signal transduction
GO:0044448	0.00506594708818	0.666666666667	WIPF2 WASL WIPF1 WIPF3	cell cortex part
REAC:R-HSA-373753	0.00510333351271	0.333333333333	NCK1 WASL	Nephrin family interactions
GO:0051015	0.00585299185536	0.666666666667	WIPF2 WASL WIPF1 WIPF3	actin filament binding
GO:0002764	0.00594566736806	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	immune response-regulating signaling pathway
WP:WP2272	0.00734453778716	0.333333333333	NCK1 WASL	Pathogenic Escherichia coli infection
GO:0002253	0.00944223313621	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	activation of immune response
GO:0030036	0.0119564905365	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	actin cytoskeleton organization
MIRNA:hsa-miR-99a-3p	0.0159781671505	0.333333333333	WIPF2 WIPF1	hsa-miR-99a-3p
REAC:R-HSA-168256	0.0201098402149	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Immune System
REAC:R-HSA-373752	0.0217814503669	0.333333333333	NCK1 WASL	Netrin-1 signaling
GO:0050778	0.0222446676534	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	positive regulation of immune response
GO:0005938	0.0222594167129	0.666666666667	WIPF2 WASL WIPF1 WIPF3	cell cortex
GO:0030029	0.0240712813761	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	actin filament-based process
CORUM:2513	0.0249904952816	0.166666666667	WASL	N-WASp homomer complex
REAC:R-HSA-162582	0.0348492364063	0.833333333333	NCK1 WIPF3 WIPF1 WASL WIPF2	Signal Transduction
MIRNA:hsa-miR-99b-3p	0.040608580687	0.333333333333	WIPF2 WIPF1	hsa-miR-99b-3p
CORUM:2297	0.0499726005494	0.166666666667	WASL	ABI1-WASL complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
WIPF1	WASL	0.995	0.924	hein_WMM bioplex (WASL) bioplex_WMM
WIPF3	WASL	0.968	0.88	bioplex (WASL) bioplex_WMM
WIPF2	WASL	0.833	0.78	hein_WMM bioplex (WASL) bioplex_WMM
NCK1	WIPF2	0.116	0.389	hein_WMM bioplex_WMM youn_WMM hein (NCK1)
MEA1	WASL	0.085	0.348	fraction
WIPF1	NCK1	0.028	0.231	hein_WMM bioplex_WMM hein (NCK1)
NCK1	WASL	0.02	0.189	hein_WMM bioplex_WMM youn_WMM hein (NCK1) gupta_WMM
WIPF1	WIPF2	0.017	0.166	hein_WMM bioplex_WMM WMM_only
WIPF1	WIPF3	0.014	0.141	bioplex_WMM WMM_only
WIPF2	WIPF3	0.014	0.141	bioplex_WMM WMM_only
NCK1	WIPF3	0.008	0.085	bioplex_WMM WMM_only

Images

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Complex HuMAP2_01376 has an average edge precision of 0.389 which is ranked 3439 out of all 6965 complexes.

Related Complexes

Genename	Complexes
WIPF2	HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_04864 HuMAP2_05979
WIPF1	HuMAP2_00621 HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_05979
NCK1	HuMAP2_01376 HuMAP2_04106 HuMAP2_04864
WIPF3	HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_04864 HuMAP2_05979
MEA1	HuMAP2_00403 HuMAP2_01376 HuMAP2_02646 HuMAP2_03989 HuMAP2_04106 HuMAP2_04864 HuMAP2_05731 HuMAP2_05979
WASL	HuMAP2_01376 HuMAP2_03857 HuMAP2_04106 HuMAP2_04864 HuMAP2_05979

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01376