hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01377
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RUVBL2 | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | UniProt NCBI |
| RUVBL1 | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | UniProt NCBI |
| INO80B | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | UniProt NCBI |
| INO80 | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | UniProt NCBI |
| ZNHIT1 | Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet) | UniProt NCBI |
| SRCAP | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | UniProt NCBI |
| INO80C | INO80 complex subunit C (IES6 homolog) (hIes6) | UniProt NCBI |
| NFRKB | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | UniProt NCBI |
| ACTR5 | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | UniProt NCBI |
| INO80D | INO80 complex subunit D | UniProt NCBI |
| DPCD | Protein DPCD | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:302 | 2.39466793015e-22 | 0.727272727273 | RUVBL2 ACTR5 INO80C INO80D NFRKB RUVBL1 INO80B INO80 | INO80 chromatin remodeling complex |
| GO:0097346 | 5.65543274378e-20 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | INO80-type complex |
| GO:0031011 | 3.28987139536e-15 | 0.636363636364 | RUVBL2 ACTR5 INO80C NFRKB INO80 INO80B RUVBL1 | Ino80 complex |
| GO:0033202 | 3.28987139536e-15 | 0.636363636364 | RUVBL2 ACTR5 INO80C NFRKB INO80 INO80B RUVBL1 | DNA helicase complex |
| GO:0070603 | 4.43772095924e-15 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | SWI/SNF superfamily-type complex |
| GO:1904949 | 6.3768760463e-15 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | ATPase complex |
| REAC:R-HSA-5696394 | 2.81457292399e-14 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696399 | 9.99241038469e-12 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5689603 | 3.51816658388e-11 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | UCH proteinases |
| REAC:R-HSA-5696398 | 6.97732824433e-11 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | Nucleotide Excision Repair |
| CORUM:304 | 2.28254486498e-09 | 0.363636363636 | SRCAP ZNHIT1 RUVBL2 RUVBL1 | SRCAP-associated chromatin remodeling complex |
| REAC:R-HSA-5688426 | 3.64790465546e-08 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | Deubiquitination |
| REAC:R-HSA-73894 | 1.36038913039e-07 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | DNA Repair |
| GO:0006338 | 1.52688865158e-07 | 0.636363636364 | SRCAP RUVBL2 INO80C ACTR5 ZNHIT1 RUVBL1 INO80 | chromatin remodeling |
| CORUM:799 | 2.42644341986e-06 | 0.272727272727 | SRCAP RUVBL2 RUVBL1 | DMAP1-associated complex |
| GO:0000812 | 3.97303919439e-06 | 0.363636363636 | SRCAP ZNHIT1 RUVBL2 RUVBL1 | Swr1 complex |
| GO:0016579 | 4.66825252667e-06 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | protein deubiquitination |
| GO:0000790 | 5.68472937409e-06 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | nuclear chromatin |
| GO:0070646 | 7.2801543517e-06 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | protein modification by small protein removal |
| GO:0000785 | 2.49645853089e-05 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | chromatin |
| GO:0044454 | 3.34710864472e-05 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | nuclear chromosome part |
| GO:0000228 | 4.24256307087e-05 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | nuclear chromosome |
| CORUM:1173 | 0.000100616904936 | 0.181818181818 | RUVBL2 RUVBL1 | TIP49-TIP48-BAF53 complex |
| GO:0043044 | 0.000120845473514 | 0.454545454545 | ACTR5 SRCAP ZNHIT1 RUVBL1 INO80 | ATP-dependent chromatin remodeling |
| CORUM:0000000 | 0.000238379812555 | 0.909090909091 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80B INO80D NFRKB RUVBL1 INO80C INO80 | CORUM root |
| GO:1902494 | 0.00031759147892 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | catalytic complex |
| CORUM:525 | 0.000335119479973 | 0.181818181818 | RUVBL2 RUVBL1 | TIP60 histone acetylase complex |
| CORUM:1171 | 0.000335119479973 | 0.181818181818 | RUVBL2 RUVBL1 | c-MYC-ATPase-helicase complex |
| CORUM:1170 | 0.000335119479973 | 0.181818181818 | RUVBL2 RUVBL1 | c-MYC-ATPase-helicase complex |
| GO:0044427 | 0.000390043020212 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | chromosomal part |
| CORUM:1166 | 0.00050247669008 | 0.181818181818 | RUVBL2 RUVBL1 | p400-associated complex |
| GO:0005694 | 0.000537342674704 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 ACTR5 INO80C NFRKB RUVBL1 INO80B INO80 | chromosome |
| CORUM:787 | 0.000937200833563 | 0.181818181818 | RUVBL2 RUVBL1 | NuA4/Tip60-HAT complex B |
| CORUM:781 | 0.00120448701596 | 0.181818181818 | RUVBL2 RUVBL1 | URI complex (Unconventional prefoldin RPB5 Interactor) |
| REAC:R-HSA-597592 | 0.00161984734598 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | Post-translational protein modification |
| REAC:R-HSA-171319 | 0.0016286415525 | 0.181818181818 | RUVBL2 RUVBL1 | Telomere Extension By Telomerase |
| GO:0006325 | 0.00193227521823 | 0.636363636364 | SRCAP RUVBL2 INO80C ACTR5 ZNHIT1 RUVBL1 INO80 | chromatin organization |
| CORUM:2857 | 0.00303854694462 | 0.181818181818 | RUVBL2 RUVBL1 | NuA4/Tip60 HAT complex |
| CORUM:798 | 0.00350460312996 | 0.181818181818 | RUVBL2 RUVBL1 | NuA4/Tip60-HAT complex A |
| CORUM:528 | 0.00350460312996 | 0.181818181818 | RUVBL2 RUVBL1 | NuA4/Tip60-HAT complex |
| CORUM:529 | 0.00400364699879 | 0.181818181818 | RUVBL2 RUVBL1 | NuA4/Tip60-HAT complex |
| GO:0000118 | 0.00469004521715 | 0.363636363636 | SRCAP ZNHIT1 RUVBL2 RUVBL1 | histone deacetylase complex |
| WP:WP2361 | 0.0107996024528 | 0.181818181818 | INO80D RUVBL1 | Gastric Cancer Network 1 |
| CORUM:5386 | 0.0116588714032 | 0.181818181818 | INO80C RUVBL1 | MLL1-WDR5 complex |
| REAC:R-HSA-392499 | 0.0178727158748 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | Metabolism of proteins |
| GO:0070647 | 0.018990655473 | 0.636363636364 | ACTR5 INO80C INO80D NFRKB INO80 INO80B RUVBL1 | protein modification by small protein conjugation or removal |
| TF:M09608_1 | 0.0378612325507 | 0.818181818182 | SRCAP ZNHIT1 RUVBL2 DPCD INO80B INO80D ACTR5 RUVBL1 INO80 | Factor: Erg; motif: NNACCGGAARTSN; match class: 1 |
| GO:0071339 | 0.0434092832834 | 0.272727272727 | INO80C RUVBL2 RUVBL1 | MLL1 complex |
| GO:0044665 | 0.0434092832834 | 0.272727272727 | INO80C RUVBL2 RUVBL1 | MLL1/2 complex |
| REAC:R-HSA-180786 | 0.0467760136448 | 0.181818181818 | RUVBL2 RUVBL1 | Extension of Telomeres |
| GO:0051276 | 0.0471465755723 | 0.636363636364 | SRCAP RUVBL2 INO80C ACTR5 ZNHIT1 RUVBL1 INO80 | chromosome organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RUVBL2 | RUVBL1 | 1.0 | 0.949 | hein_WMM bioplex (RUVBL1,RUVBL2) bioplex_WMM Guru boldt hein (RUVBL1,RUVBL2) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| INO80 | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| NFRKB | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | NFRKB | 0.997 | 0.93 | hein_WMM bioplex_WMM Malo fraction |
| ACTR5 | RUVBL1 | 0.995 | 0.924 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (ACTR5,RUVBL1) fraction boldt_WMM |
| RUVBL2 | DPCD | 0.995 | 0.923 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM boldt_WMM |
| RUVBL2 | INO80 | 0.987 | 0.901 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| INO80 | RUVBL1 | 0.973 | 0.886 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) |
| NFRKB | RUVBL1 | 0.925 | 0.843 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM fraction boldt_WMM |
| RUVBL1 | ZNHIT1 | 0.912 | 0.834 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM |
| INO80D | RUVBL1 | 0.906 | 0.829 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) |
| RUVBL1 | SRCAP | 0.905 | 0.828 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM boldt_WMM |
| INO80B | RUVBL1 | 0.896 | 0.821 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM |
| DPCD | RUVBL1 | 0.885 | 0.816 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) gupta_WMM boldt_WMM |
| INO80B | RUVBL2 | 0.851 | 0.791 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| RUVBL2 | INO80D | 0.831 | 0.778 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| INO80C | RUVBL1 | 0.825 | 0.774 | hein_WMM bioplex (RUVBL1) bioplex_WMM hein (RUVBL1) |
| RUVBL2 | ZNHIT1 | 0.762 | 0.749 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| RUVBL2 | INO80C | 0.728 | 0.735 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| RUVBL2 | ACTR5 | 0.702 | 0.723 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (ACTR5,RUVBL2) boldt_WMM |
| RUVBL2 | NFRKB | 0.604 | 0.672 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM boldt_WMM |
| RUVBL2 | SRCAP | 0.595 | 0.666 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM boldt_WMM |
| INO80C | ACTR5 | 0.337 | 0.527 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80D | ACTR5 | 0.074 | 0.356 | hein_WMM bioplex_WMM hein (ACTR5) |
| ZNHIT1 | SRCAP | 0.032 | 0.245 | hein_WMM bioplex_WMM WMM_only |
| INO80 | INO80C | 0.023 | 0.206 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ACTR5 | 0.023 | 0.211 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80B | INO80C | 0.022 | 0.196 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80 | 0.019 | 0.183 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80D | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80C | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| INO80B | NFRKB | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| INO80C | NFRKB | 0.016 | 0.161 | hein_WMM bioplex_WMM WMM_only |
| INO80D | NFRKB | 0.015 | 0.151 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80 | 0.015 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| INO80D | DPCD | 0.013 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| DPCD | ACTR5 | 0.012 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| INO80B | DPCD | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| INO80C | DPCD | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| DPCD | ZNHIT1 | 0.011 | 0.148 | hein_WMM bioplex_WMM WMM_only |
| INO80D | ZNHIT1 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| NFRKB | DPCD | 0.011 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| INO80 | DPCD | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| ACTR5 | ZNHIT1 | 0.01 | 0.131 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ZNHIT1 | 0.01 | 0.13 | hein_WMM bioplex_WMM WMM_only |
| INO80C | ZNHIT1 | 0.01 | 0.126 | hein_WMM bioplex_WMM WMM_only |
| DPCD | SRCAP | 0.01 | 0.104 | hein_WMM bioplex_WMM WMM_only |
| NFRKB | ZNHIT1 | 0.009 | 0.105 | hein_WMM bioplex_WMM WMM_only |
| INO80 | ZNHIT1 | 0.009 | 0.104 | hein_WMM bioplex_WMM WMM_only |
| INO80D | SRCAP | 0.009 | 0.104 | hein_WMM bioplex_WMM WMM_only |
| INO80B | SRCAP | 0.009 | 0.094 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| ACTR5 | SRCAP | 0.009 | 0.1 | hein_WMM bioplex_WMM WMM_only |
| INO80C | SRCAP | 0.008 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| NFRKB | SRCAP | 0.008 | 0.082 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| INO80 | SRCAP | 0.008 | 0.033 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01377 has an average edge precision of 0.428 which is ranked 3040 out of all 6965 complexes.
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