hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01434
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBAC1 | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (E3 ubiquitin-protein ligase subunit KPC2) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | UniProt NCBI |
| ZNF274 | Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2) | UniProt NCBI |
| FARP2 | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | UniProt NCBI |
| RNF123 | E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) (RING-type E3 ubiquitin transferase RNF123) | UniProt NCBI |
| RPS27A | Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)] | UniProt NCBI |
| FAM78B | Protein FAM78B | UniProt NCBI |
| THAP7 | THAP domain-containing protein 7 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:386 | 1.007158685e-05 | 0.285714285714 | UBAC1 RNF123 | Ubiquitin E3 ligase (UBADC1, RNF123) |
| REAC:R-HSA-983168 | 0.0411773376996 | 0.428571428571 | UBAC1 RPS27A RNF123 | Antigen processing: Ubiquitination & Proteasome degradation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBAC1 | RNF123 | 0.887 | 0.818 | bioplex (UBAC1) bioplex_WMM |
| THAP7 | RPS27A | 0.153 | 0.413 | bioplex (THAP7) bioplex_WMM |
| RPS27A | UBAC1 | 0.142 | 0.406 | bioplex (UBAC1) bioplex_WMM gupta_WMM |
| RPS27A | FAM78B | 0.03 | 0.239 | bioplex (FAM78B) bioplex_WMM |
| RPS27A | FARP2 | 0.023 | 0.205 | bioplex (FARP2) bioplex_WMM |
| RPS27A | ZNF274 | 0.021 | 0.189 | bioplex (ZNF274) bioplex_WMM |
| RPS27A | RNF123 | 0.006 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01434 has an average edge precision of 0.325 which is ranked 4281 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBAC1 | HuMAP2_01434 HuMAP2_04430 |
| ZNF274 | HuMAP2_01434 |
| FARP2 | HuMAP2_01434 |
| RNF123 | HuMAP2_01434 HuMAP2_04430 |
| RPS27A | HuMAP2_00543 HuMAP2_01434 HuMAP2_02207 HuMAP2_03749 |
| FAM78B | HuMAP2_01434 |
| THAP7 | HuMAP2_00543 HuMAP2_01434 |