hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01439

Confidence: Medium

Genename	Protein Name	Links
TIMMDC1	Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1)	UniProt NCBI
TMEM263	Transmembrane protein 263	UniProt NCBI
TMEM126B	Complex I assembly factor TMEM126B, mitochondrial (Transmembrane protein 126B)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4324	0.00131875812108	0.666666666667	TMEM126B TIMMDC1	Mitochondrial complex I assembly model OXPHOS system
HP:0012748	0.00384043859485	0.666666666667	TMEM126B TIMMDC1	Focal T2 hyperintense brainstem lesion
HP:0008316	0.00410511241748	0.666666666667	TMEM126B TIMMDC1	Abnormal mitochondria in muscle tissue
HP:0012747	0.00495195349433	0.666666666667	TMEM126B TIMMDC1	Abnormal brainstem MRI signal intensity
HP:0025116	0.00525183643236	0.666666666667	TMEM126B TIMMDC1	Fetal distress
HP:0011923	0.00525183643236	0.666666666667	TMEM126B TIMMDC1	Decreased activity of mitochondrial complex I
HP:0007704	0.00525183643236	0.666666666667	TMEM126B TIMMDC1	Paroxysmal involuntary eye movements
HP:0000114	0.00587799905401	0.666666666667	TMEM126B TIMMDC1	Proximal tubulopathy
HP:0004366	0.0068832170429	0.666666666667	TMEM126B TIMMDC1	Abnormality of glycolysis
HP:0003542	0.0068832170429	0.666666666667	TMEM126B TIMMDC1	Increased serum pyruvate
REAC:R-HSA-6799198	0.008858224502	0.666666666667	TMEM126B TIMMDC1	Complex I biogenesis
HP:0011013	0.00913104209388	0.666666666667	TMEM126B TIMMDC1	Abnormal circulating carbohydrate concentration
HP:0003737	0.0116951722183	0.666666666667	TMEM126B TIMMDC1	Mitochondrial myopathy
HP:0001138	0.0116951722183	0.666666666667	TMEM126B TIMMDC1	Optic neuropathy
HP:0008972	0.0161338784795	0.666666666667	TMEM126B TIMMDC1	Decreased activity of mitochondrial respiratory chain
HP:0011922	0.0166709261154	0.666666666667	TMEM126B TIMMDC1	Abnormal activity of mitochondrial respiratory chain
HP:0000817	0.0172167410086	0.666666666667	TMEM126B TIMMDC1	Poor eye contact
HP:0003800	0.0183346678183	0.666666666667	TMEM126B TIMMDC1	Muscle abnormality related to mitochondrial dysfunction
HP:0030085	0.023156827915	0.666666666667	TMEM126B TIMMDC1	Abnormal CSF lactate level
HP:0002490	0.023156827915	0.666666666667	TMEM126B TIMMDC1	Increased CSF lactate
REAC:R-HSA-611105	0.0291450496188	0.666666666667	TMEM126B TIMMDC1	Respiratory electron transport
HP:0000124	0.0292514239306	0.666666666667	TMEM126B TIMMDC1	Renal tubular dysfunction
HP:0000735	0.029972334664	0.666666666667	TMEM126B TIMMDC1	Impaired social interactions
HP:0025454	0.0329433889933	0.666666666667	TMEM126B TIMMDC1	Abnormal CSF metabolite level
HP:0002415	0.0384790851177	0.666666666667	TMEM126B TIMMDC1	Leukodystrophy
REAC:R-HSA-163200	0.0444303896492	0.666666666667	TMEM126B TIMMDC1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
HP:0000543	0.0453293273008	0.666666666667	TMEM126B TIMMDC1	Optic disc pallor

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TMEM263	TIMMDC1	0.022	0.196	bioplex (TIMMDC1) bioplex_WMM boldt boldt_WMM
TMEM126B	TIMMDC1	0.021	0.195	bioplex (TIMMDC1,TMEM126B) bioplex_WMM
TMEM263	TMEM126B	0.004	0.009	bioplex_WMM WMM_only

Images

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Complex HuMAP2_01439 has an average edge precision of 0.133 which is ranked 6813 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TIMMDC1	HuMAP2_00306 HuMAP2_01439 HuMAP2_06446
TMEM263	HuMAP2_00306 HuMAP2_01439 HuMAP2_06446
TMEM126B	HuMAP2_00306 HuMAP2_01439 HuMAP2_04892 HuMAP2_06446

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01439