hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01440
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAMA5 | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) | UniProt NCBI |
| CCAR1 | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | UniProt NCBI |
| LAMC1 | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | UniProt NCBI |
| LAMB2 | Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) | UniProt NCBI |
| LAMB4 | Laminin subunit beta-4 (Laminin beta-1-related protein) | UniProt NCBI |
| AGA | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2319 | 2.25288169953e-08 | 0.5 | LAMB2 LAMC1 LAMA5 | ITGA6-ITGB4-Laminin10/12 complex |
| GO:0043256 | 2.56043303928e-08 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | laminin complex |
| KEGG:04512 | 4.79476375504e-07 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | ECM-receptor interaction |
| KEGG:05146 | 6.80094402209e-07 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Amoebiasis |
| KEGG:05222 | 9.37805281521e-07 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Small cell lung cancer |
| WP:WP4658 | 9.53390687704e-07 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Small cell lung cancer |
| KEGG:05145 | 1.02328638119e-06 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Toxoplasmosis |
| GO:0043260 | 1.81637152046e-06 | 0.5 | LAMB2 LAMC1 LAMA5 | laminin-11 complex |
| WP:WP453 | 1.99108246857e-06 | 0.5 | LAMB2 LAMC1 LAMA5 | Inflammatory Response Pathway |
| WP:WP244 | 8.15311651655e-06 | 0.5 | LAMB2 LAMC1 LAMA5 | Alpha 6 Beta 4 signaling pathway |
| KEGG:04510 | 1.71027631169e-05 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Focal adhesion |
| REAC:R-HSA-8874081 | 1.94360151212e-05 | 0.5 | LAMB2 LAMC1 LAMA5 | MET activates PTK2 signaling |
| REAC:R-HSA-3000157 | 2.40800825039e-05 | 0.5 | LAMB2 LAMC1 LAMA5 | Laminin interactions |
| GO:0044420 | 2.40824494048e-05 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | extracellular matrix component |
| REAC:R-HSA-8875878 | 4.60355113742e-05 | 0.5 | LAMB2 LAMC1 LAMA5 | MET promotes cell motility |
| GO:0005604 | 6.49684869516e-05 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | basement membrane |
| WP:WP4172 | 8.1191833253e-05 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | PI3K-Akt Signaling Pathway |
| CORUM:2318 | 8.38550741504e-05 | 0.333333333333 | LAMA5 LAMC1 | ITGA6-ITGB4-Laminin10/12 complex |
| KEGG:04151 | 0.00010854557604 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.000126915092095 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Human papillomavirus infection |
| REAC:R-HSA-3000171 | 0.000172834826973 | 0.5 | LAMB2 LAMC1 LAMA5 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 0.000269929792646 | 0.5 | LAMB2 LAMC1 LAMA5 | ECM proteoglycans |
| REAC:R-HSA-6806834 | 0.00036649373235 | 0.5 | LAMB2 LAMC1 LAMA5 | Signaling by MET |
| GO:0034446 | 0.000574036481079 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | substrate adhesion-dependent cell spreading |
| KEGG:05200 | 0.000619708787865 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | Pathways in cancer |
| WP:WP2911 | 0.00116964360656 | 0.333333333333 | LAMB2 LAMC1 | miRNA targets in ECM and membrane receptors |
| WP:WP306 | 0.00159070884596 | 0.5 | LAMB2 LAMC1 LAMA5 | Focal Adhesion |
| GO:0005201 | 0.0038519413587 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | extracellular matrix structural constituent |
| WP:WP3932 | 0.00399196485232 | 0.5 | LAMB2 LAMC1 LAMA5 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP2572 | 0.0107960863784 | 0.333333333333 | LAMB2 LAMA5 | Primary Focal Segmental Glomerulosclerosis FSGS |
| WP:WP2806 | 0.0174151198914 | 0.333333333333 | LAMA5 LAMC1 | Human Complement System |
| REAC:R-HSA-1474244 | 0.0179459751507 | 0.5 | LAMB2 LAMC1 LAMA5 | Extracellular matrix organization |
| GO:0043259 | 0.020283420769 | 0.333333333333 | LAMA5 LAMC1 | laminin-10 complex |
| GO:0031589 | 0.0405607523961 | 0.666666666667 | LAMB2 LAMA5 LAMC1 LAMB4 | cell-substrate adhesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAMC1 | LAMB2 | 0.354 | 0.539 | bioplex_WMM fraction |
| LAMC1 | LAMA5 | 0.288 | 0.489 | bioplex_WMM Guru fraction |
| CCAR1 | LAMC1 | 0.118 | 0.393 | fraction |
| LAMB2 | LAMA5 | 0.09 | 0.355 | bioplex_WMM fraction |
| LAMB4 | LAMA5 | 0.027 | 0.229 | fraction |
| LAMA5 | AGA | 0.022 | 0.205 | fraction |
| CCAR1 | LAMB2 | 0.007 | 0.0 | gupta_WMM WMM_only |
| LAMC1 | AGA | 0.004 | 0.012 | bioplex (AGA) bioplex_WMM |
| LAMB2 | AGA | 0.0 | 0.014 | bioplex (AGA) fraction |
Images
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Complex HuMAP2_01440 has an average edge precision of 0.248 which is ranked 5404 out of all 6965 complexes.
Related Complexes