hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01454
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TOP3B | DNA topoisomerase 3-beta-1 (EC 5.6.2.2) (DNA topoisomerase III beta-1) | UniProt NCBI |
| FXR2 | Fragile X mental retardation syndrome-related protein 2 | UniProt NCBI |
| FMR1 | Synaptic functional regulator FMR1 (Fragile X mental retardation protein 1) (FMRP) (Protein FMR-1) | UniProt NCBI |
| FXR1 | Fragile X mental retardation syndrome-related protein 1 (hFXR1p) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044326 | 3.63274304092e-07 | 0.75 | FXR1 FMR1 FXR2 | dendritic spine neck |
| GO:1902737 | 1.45302402969e-06 | 0.75 | FXR1 FMR1 FXR2 | dendritic filopodium |
| KEGG:03013 | 0.000156303289806 | 0.75 | FXR1 FMR1 FXR2 | RNA transport |
| GO:0051489 | 0.00281780772825 | 0.75 | FXR1 FMR1 FXR2 | regulation of filopodium assembly |
| GO:0046847 | 0.00667745927673 | 0.75 | FXR1 FMR1 FXR2 | filopodium assembly |
| GO:0033592 | 0.00811409485621 | 0.5 | FXR1 FMR1 | RNA strand annealing activity |
| GO:0030175 | 0.0111781410126 | 0.75 | FXR1 FMR1 FXR2 | filopodium |
| GO:0000381 | 0.011776375189 | 0.75 | FXR1 FMR1 FXR2 | regulation of alternative mRNA splicing, via spliceosome |
| GO:0005844 | 0.0165706850483 | 0.75 | FXR1 FMR1 FXR2 | polysome |
| GO:0000380 | 0.017346559408 | 0.75 | FXR1 FMR1 FXR2 | alternative mRNA splicing, via spliceosome |
| GO:0043197 | 0.0206918321066 | 0.75 | FXR1 FMR1 FXR2 | dendritic spine |
| GO:0044309 | 0.0215903857674 | 0.75 | FXR1 FMR1 FXR2 | neuron spine |
| GO:0003730 | 0.023464682987 | 0.75 | FXR1 FMR1 FXR2 | mRNA 3'-UTR binding |
| GO:0030426 | 0.023464682987 | 0.75 | FXR1 FMR1 FXR2 | growth cone |
| GO:0030427 | 0.0275320606423 | 0.75 | FXR1 FMR1 FXR2 | site of polarized growth |
| GO:0048024 | 0.0344730150111 | 0.75 | FXR1 FMR1 FXR2 | regulation of mRNA splicing, via spliceosome |
| GO:2001022 | 0.0410761885593 | 0.75 | FXR1 FMR1 FXR2 | positive regulation of response to DNA damage stimulus |
| GO:0045727 | 0.0439367749778 | 0.75 | FXR1 FMR1 FXR2 | positive regulation of translation |
| CORUM:5360 | 0.0499140284799 | 0.25 | FXR1 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
| CORUM:7407 | 0.0499140284799 | 0.25 | TOP3B | TOP3B-c complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FMR1 | FXR1 | 0.976 | 0.888 | hein_WMM youn (FMR1,FXR1) bioplex (FMR1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FMR1 | FXR2 | 0.778 | 0.752 | hein_WMM youn (FMR1,FXR2) bioplex (FMR1,FXR2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FXR2 | FXR1 | 0.281 | 0.487 | hein_WMM youn (FXR1,FXR2) bioplex (FXR2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FMR1 | TOP3B | 0.161 | 0.418 | hein_WMM youn (FMR1,TOP3B) youn_WMM treiber_WMM |
| TOP3B | FXR2 | 0.029 | 0.23 | hein_WMM youn (FXR2,TOP3B) youn_WMM gupta_WMM treiber_WMM |
| TOP3B | FXR1 | 0.0 | 0.014 | hein_WMM youn (FXR1,TOP3B) youn_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_01454 has an average edge precision of 0.465 which is ranked 2764 out of all 6965 complexes.
Related Complexes